iPTMnet Report for Q6P2Q9 (PRPF8)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q6P2Q9 / PRP8_HUMAN
Protein Name Pre-mRNA-processing-splicing factor 8
Gene Name Name: PRPF8
Synonyms:PRPC8;
Organism Homo sapiens (Human)

PRO ID PR:Q6P2Q9
DAG View
PRO Name pre-mRNA-processing-splicing factor 8 (human)
Definition A pre-mRNA-processing-splicing factor 8 that is encoded in the genome of human.
Short Label hPRPF8
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q6P2Q9 (PRPF8) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 22223895
R8 Methylation PhosphoSitePlus
S26 Phosphorylation PhosphoSitePlus
K29 Ubiquitination PhosphoSitePlus
K33 Ubiquitination PhosphoSitePlus
K36 Ubiquitination PhosphoSitePlus
K43 Acetylation PhosphoSitePlus
K43 Ubiquitination PhosphoSitePlus
K50 Ubiquitination PhosphoSitePlus
K68 Ubiquitination PhosphoSitePlus
R79 Methylation PhosphoSitePlus
K80 Ubiquitination PhosphoSitePlus
K93 Ubiquitination PhosphoSitePlus
Y94 Phosphorylation PhosphoSitePlus
K218 Ubiquitination PhosphoSitePlus
S236 Phosphorylation HPRD 20068231
T237 Phosphorylation HPRD 20068231
Y239 Phosphorylation HPRD   PhosphoSitePlus 20068231
T247 Phosphorylation HPRD 20068231
Y254 Phosphorylation HPRD   PhosphoSitePlus 20068231, 18452278
K267 Ubiquitination PhosphoSitePlus
K278 Ubiquitination PhosphoSitePlus
K301 Ubiquitination PhosphoSitePlus
K366 Sumoylation PhosphoSitePlus
K366 Ubiquitination PhosphoSitePlus
Y394 Phosphorylation PhosphoSitePlus
K428 Ubiquitination PhosphoSitePlus
K442 Ubiquitination PhosphoSitePlus
K449 Ubiquitination PhosphoSitePlus
K452 Ubiquitination PhosphoSitePlus
K460 Ubiquitination PhosphoSitePlus
K480 Ubiquitination PhosphoSitePlus
Y501 Phosphorylation PhosphoSitePlus
K511 Ubiquitination PhosphoSitePlus
K525 Ubiquitination PhosphoSitePlus
K528 Ubiquitination PhosphoSitePlus
K533 Ubiquitination PhosphoSitePlus
K555 Ubiquitination PhosphoSitePlus
K609 Acetylation PhosphoSitePlus
K609 Ubiquitination PhosphoSitePlus
T645 Phosphorylation PhosphoSitePlus
K670 Ubiquitination PhosphoSitePlus
K674 Ubiquitination PhosphoSitePlus
S679 Phosphorylation PhosphoSitePlus
K702 Ubiquitination PhosphoSitePlus
K705 Ubiquitination PhosphoSitePlus
C719 Methylation IEDB 31844290
K721 Ubiquitination PhosphoSitePlus
K727 Ubiquitination PhosphoSitePlus
T733 Phosphorylation PhosphoSitePlus
Y742 Phosphorylation PhosphoSitePlus
K746 Ubiquitination PhosphoSitePlus
K769 Ubiquitination PhosphoSitePlus
K785 Ubiquitination PhosphoSitePlus
K837 Ubiquitination PhosphoSitePlus
K847 Ubiquitination PhosphoSitePlus
K853 Ubiquitination PhosphoSitePlus
S859 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20068231
Y871 Phosphorylation PhosphoSitePlus
K932 Ubiquitination PhosphoSitePlus
K941 Ubiquitination PhosphoSitePlus
K983 Ubiquitination PhosphoSitePlus
K987 Ubiquitination PhosphoSitePlus
Y1008 Phosphorylation PhosphoSitePlus
T1010 Phosphorylation PhosphoSitePlus
K1012 Ubiquitination PhosphoSitePlus
K1020 Methylation PhosphoSitePlus
K1020 Ubiquitination PhosphoSitePlus
S1027 Phosphorylation HPRD 20068231
Y1028 Phosphorylation HPRD 20068231
C1089 Methylation IEDB 31844290
Y1091 Phosphorylation PhosphoSitePlus
Y1113 Phosphorylation PhosphoSitePlus
Y1128 Phosphorylation PhosphoSitePlus
K1131 Ubiquitination PhosphoSitePlus
K1144 Ubiquitination PhosphoSitePlus
R1151 Methylation PhosphoSitePlus
K1158 Ubiquitination PhosphoSitePlus
C1200 Methylation IEDB 31844290
R1201 Methylation PhosphoSitePlus
Y1204 Phosphorylation PhosphoSitePlus
K1210 Ubiquitination PhosphoSitePlus
K1222 Ubiquitination PhosphoSitePlus
S1251 O-Glycosylation GlyGen 30444036, 34725712, 26853435, ...33214551, 33465208, 34019948, 35083852, 32119511, 28510447, 22121020, 34229054
T1255 O-Glycosylation GlyGen 33465208
T1257 O-Glycosylation GlyGen 33465208
K1294 Ubiquitination PhosphoSitePlus
K1300 Ubiquitination PhosphoSitePlus
K1306 Ubiquitination PhosphoSitePlus
S1338 Phosphorylation PhosphoSitePlus
K1344 Ubiquitination PhosphoSitePlus
S1355 Phosphorylation HPRD   PhosphoSitePlus 19651622
S1358 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y1369 Phosphorylation HPRD   PhosphoSitePlus 19651622
K1392 Ubiquitination PhosphoSitePlus
R1401 Methylation PhosphoSitePlus
T1404 Phosphorylation PhosphoSitePlus
R1414 Methylation PhosphoSitePlus
R1418 Methylation PhosphoSitePlus
K1425 Methylation PhosphoSitePlus   UniProt 24129315
K1425 Ubiquitination PhosphoSitePlus
Y1432 Phosphorylation PhosphoSitePlus
K1434 Ubiquitination PhosphoSitePlus
K1443 Methylation PhosphoSitePlus
K1443 Ubiquitination PhosphoSitePlus
K1449 Ubiquitination PhosphoSitePlus
K1463 Acetylation PhosphoSitePlus   UniProt 19608861
K1463 Ubiquitination PhosphoSitePlus
Y1470 Phosphorylation HPRD   PhosphoSitePlus 20068231
S1512 Phosphorylation PhosphoSitePlus
K1516 Methylation PhosphoSitePlus
K1517 Methylation PhosphoSitePlus
S1524 Phosphorylation PhosphoSitePlus
S1539 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 20068231, 18220336
T1608 Phosphorylation PhosphoSitePlus
K1649 Ubiquitination PhosphoSitePlus
Y1671 Phosphorylation PhosphoSitePlus
K1732 Ubiquitination PhosphoSitePlus
K1735 Ubiquitination PhosphoSitePlus
Y1741 Phosphorylation PhosphoSitePlus
K1792 Ubiquitination PhosphoSitePlus
K1801 Ubiquitination PhosphoSitePlus
K1831 Ubiquitination PhosphoSitePlus
K1838 Ubiquitination PhosphoSitePlus
K1840 Ubiquitination PhosphoSitePlus
S1851 Phosphorylation PhosphoSitePlus
K1859 Ubiquitination PhosphoSitePlus
K1866 Ubiquitination PhosphoSitePlus
S1887 Phosphorylation PhosphoSitePlus
K1898 Ubiquitination PhosphoSitePlus
K1901 Ubiquitination PhosphoSitePlus
K1955 Ubiquitination PhosphoSitePlus
K1958 Ubiquitination PhosphoSitePlus
T1972 Phosphorylation PhosphoSitePlus
K1984 Ubiquitination PhosphoSitePlus
Y1991 Phosphorylation HPRD   PhosphoSitePlus 20068231
K1993 Ubiquitination PhosphoSitePlus
K1994 Ubiquitination PhosphoSitePlus
K2031 Ubiquitination PhosphoSitePlus
K2034 Ubiquitination PhosphoSitePlus
S2037 Phosphorylation PhosphoSitePlus
T2042 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17525332
K2049 Ubiquitination PhosphoSitePlus
S2057 Phosphorylation PhosphoSitePlus
Y2062 Phosphorylation PhosphoSitePlus
T2064 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17525332
K2070 Ubiquitination PhosphoSitePlus
S2079 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
R2086 Methylation PhosphoSitePlus
T2087 Phosphorylation HPRD   PhosphoSitePlus 19664994
Y2091 Phosphorylation PhosphoSitePlus
S2093 Phosphorylation PhosphoSitePlus
K2098 Ubiquitination PhosphoSitePlus
Y2102 Phosphorylation PhosphoSitePlus
K2108 Ubiquitination PhosphoSitePlus
K2113 Ubiquitination PhosphoSitePlus
K2140 Ubiquitination PhosphoSitePlus
S2189 Phosphorylation PhosphoSitePlus
K2198 Ubiquitination PhosphoSitePlus
S2205 Phosphorylation PhosphoSitePlus
C2216 Methylation IEDB 31844290
K2244 Ubiquitination PhosphoSitePlus
Y2256 Phosphorylation PhosphoSitePlus
K2293 Ubiquitination PhosphoSitePlus
Y2294 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
A2 T2 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R8 L8 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R8 Q8 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
S26 L26 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:8618 / oral cavity cancer [ cosmic ]
K80 R80 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K80 N80 Biomuta DOID:363 / uterine cancer [ icgc ]
S236 L236 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y394 H394 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K428 N428 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K449 Q449 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S679 T679 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
K702 E702 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K853 R853 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K1020 N1020 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
K1020 M1020 Biomuta DOID:5158 / pleural cancer [ cosmic ]
Y1028 N1028 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K1144 T1144 Biomuta DOID:363 / uterine cancer [ icgc ]
R1151 Q1151 Biomuta DOID:10283 / prostate cancer [ cosmic ]
R1201 H1201 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
R1201 C1201 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ] DOID:1319 / brain cancer [ cosmic, icgc ]
S1251 F1251 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K1300 E1300 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K1344 T1344 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y1369 C1369 Biomuta DOID:1319 / brain cancer [ cosmic ]
Y1369 N1369 Biomuta DOID:10283 / prostate cancer [ cosmic ]
R1414 H1414 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
R1414 C1414 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
R1418 Q1418 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R1418 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y1432 C1432 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K1434 R1434 Biomuta DOID:4159 / skin cancer [ cosmic ]
K1649 N1649 Biomuta DOID:1324 / lung cancer [ cosmic ]
K1838 E1838 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S1887 L1887 Biomuta DOID:363 / uterine cancer [ icgc ]
K2049 R2049 Biomuta DOID:10534 / stomach cancer [ cosmic ]
Y2102 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]