iPTMnet Report for Q6P2C8 (MED27)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q6P2C8 / MED27_HUMAN
Protein Name Mediator of RNA polymerase II transcription subunit 27
Gene Name Name: MED27
Synonyms:CRSP34;
Organism Homo sapiens (Human)

PRO ID PR:Q6P2C8
DAG View
PRO Name mediator of RNA polymerase II transcription subunit 27 (human)
Definition A mediator of RNA polymerase II transcription subunit 27 that is encoded in the genome of human.
Short Label hMED27
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q6P2C8 (MED27) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S27 Phosphorylation PhosphoSitePlus
S29 Phosphorylation PhosphoSitePlus
K36 Ubiquitination PhosphoSitePlus
K42 Ubiquitination PhosphoSitePlus
K50 Ubiquitination PhosphoSitePlus
K79 Ubiquitination PhosphoSitePlus
K100 Ubiquitination PhosphoSitePlus
Y104 Phosphorylation PhosphoSitePlus
K112 Ubiquitination PhosphoSitePlus
K116 Ubiquitination PhosphoSitePlus
S132 Phosphorylation PhosphoSitePlus   UniProt 23186163
K134 Methylation PhosphoSitePlus   UniProt 24129315
K134 Ubiquitination PhosphoSitePlus
K145 Acetylation PhosphoSitePlus
K145 Ubiquitination PhosphoSitePlus
S177 Phosphorylation PhosphoSitePlus
S181 Phosphorylation PhosphoSitePlus
K215 Ubiquitination PhosphoSitePlus
Y222 Phosphorylation PhosphoSitePlus
K227 Ubiquitination PhosphoSitePlus
S232 Phosphorylation PhosphoSitePlus
K233 Ubiquitination PhosphoSitePlus
S234 Phosphorylation PhosphoSitePlus
Y236 Phosphorylation PhosphoSitePlus
T243 Phosphorylation PhosphoSitePlus
K275 Ubiquitination PhosphoSitePlus
C281 Methylation IEDB 31844290
Site PTM Type PTM Enzyme Score Source PMID
S29 Phosphorylation HPRD 19664994


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K100 T100 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S177 F177 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K215 N215 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]