iPTMnet Report for Q6P1Q9 (METTL2B)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q6P1Q9 / MET2B_HUMAN
Protein Name tRNA N(3)-methylcytidine methyltransferase METTL2B
Gene Name Name: METTL2B
Organism Homo sapiens (Human)

PRO ID PR:Q6P1Q9
DAG View
PRO Name tRNA N(3)-methylcytidine methyltransferase METTL2B (human)
Definition A tRNA N(3)-methylcytidine methyltransferase METTL2B that is encoded in the genome of human.
Short Label hMETTL2B
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q6P1Q9 (METTL2B) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 22814378
S4 Phosphorylation PhosphoSitePlus   UniProt 23186163
K16 Ubiquitination PhosphoSitePlus
S26 Phosphorylation PhosphoSitePlus
K53 Ubiquitination PhosphoSitePlus
K66 Acetylation PhosphoSitePlus
K66 Ubiquitination PhosphoSitePlus
K76 Ubiquitination PhosphoSitePlus
K91 Ubiquitination PhosphoSitePlus
K113 Methylation PhosphoSitePlus
K113 Ubiquitination PhosphoSitePlus
K120 Ubiquitination PhosphoSitePlus
S147 Phosphorylation PhosphoSitePlus
K151 Ubiquitination PhosphoSitePlus
T154 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163, 19690332, ...20068231
S264 Phosphorylation PhosphoSitePlus
K283 Ubiquitination PhosphoSitePlus
R348 Methylation PhosphoSitePlus
K371 Ubiquitination PhosphoSitePlus
S378 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T154 Phosphorylation HPRD 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S147 N147 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K283 E283 Biomuta DOID:1324 / lung cancer [ cosmic ]
R348 H348 Biomuta DOID:1319 / brain cancer [ icgc ]
S378 R378 Biomuta DOID:2531 / hematologic cancer [ cosmic ]