iPTMnet Report for Q6P1J9 (CDC73)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q6P1J9 / CDC73_HUMAN
Protein Name Parafibromin
Gene Name Name: CDC73
Synonyms:C1orf28,HRPT2;
Organism Homo sapiens (Human)

PRO ID PR:Q6P1J9
DAG View
PRO Name parafibromin (human)
Definition A parafibromin that is encoded in the genome of human.
Short Label hCDC73
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q6P1J9 (CDC73) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22814378, 22223895
S6 Phosphorylation PhosphoSitePlus
K34 Sumoylation PhosphoSitePlus
K34 Ubiquitination PhosphoSitePlus
K47 Ubiquitination PhosphoSitePlus
T80 Phosphorylation PhosphoSitePlus
S105 Phosphorylation HPRD   PhosphoSitePlus 18452278
K136 Sumoylation PhosphoSitePlus
K150 Ubiquitination PhosphoSitePlus
K161 Sumoylation PhosphoSitePlus
K161 Ubiquitination PhosphoSitePlus
S172 Phosphorylation HPRD   PhosphoSitePlus 20068231
S174 Phosphorylation HPRD   PhosphoSitePlus 19007248
S178 Phosphorylation HPRD   PhosphoSitePlus 19007248
K181 Ubiquitination PhosphoSitePlus
K198 Sumoylation PhosphoSitePlus
K198 Ubiquitination PhosphoSitePlus
K209 Ubiquitination PhosphoSitePlus
S212 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
R234 Methylation PhosphoSitePlus
T236 Phosphorylation PhosphoSitePlus
S240 Phosphorylation HPRD 20068231
T241 Phosphorylation PhosphoSitePlus
K243 Acetylation PhosphoSitePlus
K243 Ubiquitination PhosphoSitePlus
S246 Phosphorylation PhosphoSitePlus
K247 Ubiquitination PhosphoSitePlus
K257 Ubiquitination PhosphoSitePlus
K283 Methylation PhosphoSitePlus
K283 Sumoylation PhosphoSitePlus
K283 Ubiquitination PhosphoSitePlus
Y290 Phosphorylation P00519 (ABL1) IntAct   PhosphoSitePlus   RLIMS-P 30227954, 26742426, 21726809
Y293 Phosphorylation P00519 (ABL1) IntAct   PhosphoSitePlus 26742426, 21726809
K299 Ubiquitination PhosphoSitePlus
K301 Sumoylation PhosphoSitePlus
K301 Ubiquitination PhosphoSitePlus
T314 O-Glycosylation GlyGen 33214551, 30379171, 29351928, ...34019948, 28510447, 34229054
Y315 Phosphorylation P00519 (ABL1) IntAct   PhosphoSitePlus 26742426, 21726809
K321 Ubiquitination PhosphoSitePlus
K331 Methylation PhosphoSitePlus
K331 Ubiquitination PhosphoSitePlus
K354 Ubiquitination PhosphoSitePlus
K385 Sumoylation PhosphoSitePlus
K385 Ubiquitination PhosphoSitePlus
S420 O-Glycosylation GlyGen 33214551, 30379171, 29351928, ...34019948, 28510447, 34229054
K455 Sumoylation PhosphoSitePlus
S465 Phosphorylation PhosphoSitePlus   RLIMS-P 35551175
K479 Ubiquitination PhosphoSitePlus
S500 Phosphorylation HPRD 20068231
R520 Methylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
A2 S2 Biomuta DOID:1540 / parathyroid carcinoma [ cosmic ]
A2 T2 Biomuta DOID:1319 / brain cancer [ cosmic ]
K34 N34 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K34 Q34 Biomuta DOID:3571 / liver cancer [ cosmic ]
K47 N47 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S105 P105 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S172 F172 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic ]
S174 C174 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S178 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S178 L178 Biomuta DOID:1612 / breast cancer [ cosmic ]
K181 T181 Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:363 / uterine cancer [ icgc ]
K198 E198 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K198 N198 Biomuta DOID:10283 / prostate cancer [ cosmic ]
R234 * Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:1540 / parathyroid carcinoma [ cosmic ]
R234 Q234 Biomuta DOID:1612 / breast cancer [ cosmic ]
T236 N236 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S240 N240 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K243 N243 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S246 F246 Biomuta [ cosmic ]
K247 N247 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
Y293 * Biomuta DOID:363 / uterine cancer [ cosmic ]
Y315 C315 Biomuta DOID:3571 / liver cancer [ cosmic ]
K331 E331 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K385 N385 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
R520 K520 Biomuta DOID:10534 / stomach cancer [ cosmic ]