iPTMnet Report for Q6P179 (ERAP2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q6P179 / ERAP2_HUMAN
Protein Name Endoplasmic reticulum aminopeptidase 2
Gene Name Name: ERAP2
Synonyms:LRAP;
Organism Homo sapiens (Human)

PRO ID PR:Q6P179
DAG View
PRO Name endoplasmic reticulum aminopeptidase 2 (human)
Definition An endoplasmic reticulum aminopeptidase 2 that is encoded in the genome of human.
Short Label hERAP2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q6P179 (ERAP2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
N85 N-Glycosylation GlyGen   UniProt 29741879, 22106953, 24190977
N103 N-Glycosylation GlyGen 29741879, 24190977
N119 N-Glycosylation GlyGen   UniProt 16335952, 23090970, 24190977, ...29391424, 29741879
K135 Acetylation PhosphoSitePlus
K138 Acetylation PhosphoSitePlus
K138 Ubiquitination PhosphoSitePlus
K155 Ubiquitination PhosphoSitePlus
T157 Phosphorylation PhosphoSitePlus
K181 Ubiquitination PhosphoSitePlus
N219 N-Glycosylation GlyGen   UniProt 29741879, 22106953, 29391424
K238 Ubiquitination PhosphoSitePlus
C269 Methylation IEDB 31844290
N294 N-Glycosylation GlyGen 29391424, 24190977
N405 N-Glycosylation GlyGen   UniProt 22106953
N431 N-Glycosylation GlyGen 23090970, 24190977
K473 Ubiquitination PhosphoSitePlus
K476 Ubiquitination PhosphoSitePlus
K491 Ubiquitination PhosphoSitePlus
S506 Phosphorylation PhosphoSitePlus
S516 Phosphorylation PhosphoSitePlus
K545 Ubiquitination PhosphoSitePlus
K553 Ubiquitination PhosphoSitePlus
K606 Ubiquitination PhosphoSitePlus
K608 Ubiquitination PhosphoSitePlus
K617 Ubiquitination PhosphoSitePlus
N650 N-Glycosylation GlyGen   UniProt 22106953
N714 N-Glycosylation GlyGen 29391424, 24190977
S719 Phosphorylation PhosphoSitePlus
K731 Ubiquitination PhosphoSitePlus
K832 Ubiquitination PhosphoSitePlus
K836 Ubiquitination PhosphoSitePlus
N879 N-Glycosylation GlyGen 29391424
S899 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
N85 S85 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
N103 S103 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
T157 M157 Biomuta DOID:9256 / colorectal cancer [ cosmic ]