iPTMnet Report for Q6NVY1 (HIBCH)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q6NVY1 / HIBCH_HUMAN
Protein Name 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial precursor
Gene Name Name: HIBCH
Organism Homo sapiens (Human)

PRO ID PR:Q6NVY1
DAG View
PRO Name 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial (human)
Definition A 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial that is encoded in the genome of human.
Short Label hHIBCH
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q6NVY1 (HIBCH) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K42 Ubiquitination PhosphoSitePlus
K73 Acetylation PhosphoSitePlus
K92 Acetylation PhosphoSitePlus   UniProt 19608861
K92 Ubiquitination PhosphoSitePlus
K112 Ubiquitination PhosphoSitePlus
K233 Ubiquitination PhosphoSitePlus
S234 Phosphorylation PhosphoSitePlus   UniProt 23186163
K237 Ubiquitination PhosphoSitePlus
Y247 Phosphorylation PhosphoSitePlus
K252 Ubiquitination PhosphoSitePlus
S258 Phosphorylation PhosphoSitePlus
K301 Ubiquitination PhosphoSitePlus
Y330 Phosphorylation PhosphoSitePlus
K353 Acetylation PhosphoSitePlus
S356 Phosphorylation PhosphoSitePlus   UniProt 23186163


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K42 N42 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K233 T233 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]