iPTMnet Report for Q6NUM9 (RETSAT)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q6NUM9 / RETST_HUMAN
Protein Name All-trans-retinol 13,14-reductase precursor
Gene Name Name: RETSAT
Synonyms:PPSIG;ORFNames:UNQ439/PRO872;
Organism Homo sapiens (Human)

PRO ID PR:Q6NUM9
DAG View
PRO Name all-trans-retinol 13,14-reductase (human)
Definition An all-trans-retinol 13,14-reductase that is encoded in the genome of human.
Short Label hRETSAT
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q6NUM9 (RETSAT) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S29 Phosphorylation PhosphoSitePlus
K48 Ubiquitination PhosphoSitePlus
K56 Ubiquitination PhosphoSitePlus
T100 Phosphorylation PhosphoSitePlus
K165 Ubiquitination PhosphoSitePlus
Y167 Phosphorylation PhosphoSitePlus
Y170 Phosphorylation PhosphoSitePlus
K174 Ubiquitination PhosphoSitePlus
K181 Ubiquitination PhosphoSitePlus
K183 Acetylation PhosphoSitePlus
K183 Ubiquitination PhosphoSitePlus
K193 Ubiquitination PhosphoSitePlus
K196 Ubiquitination PhosphoSitePlus
K199 Ubiquitination PhosphoSitePlus
R293 Methylation PhosphoSitePlus
S296 Phosphorylation PhosphoSitePlus
T316 Phosphorylation PhosphoSitePlus
K317 Ubiquitination PhosphoSitePlus
K330 Ubiquitination PhosphoSitePlus
K337 Ubiquitination PhosphoSitePlus
C347 Methylation IEDB 31844290
C370 Methylation IEDB 31844290
Y408 Phosphorylation PhosphoSitePlus
Y412 Phosphorylation PhosphoSitePlus
Y423 Phosphorylation PhosphoSitePlus
R453 Methylation PhosphoSitePlus
K481 Ubiquitination PhosphoSitePlus
S484 Phosphorylation PhosphoSitePlus
Y486 Phosphorylation PhosphoSitePlus
K597 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R293 P293 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
R293 Q293 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
R293 L293 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
R293 * Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
Y423 F423 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
R453 Q453 Biomuta DOID:9256 / colorectal cancer [ cosmic ]