iPTMnet Report for Q6NUM6 (TYW1B)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q6NUM6 / TYW1B_HUMAN
Protein Name S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1B
Gene Name Name: TYW1B
Synonyms:RSAFD2;
Organism Homo sapiens (Human)

PRO ID PR:Q6NUM6
DAG View
PRO Name S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1B (human)
Definition An S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1B that is encoded in the genome of human.
Short Label hTYW1B
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q6NUM6 (TYW1B) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K120 Ubiquitination PhosphoSitePlus
K124 Methylation PhosphoSitePlus
S136 Phosphorylation PhosphoSitePlus
Y138 Phosphorylation PhosphoSitePlus
S140 Phosphorylation PhosphoSitePlus
K173 Ubiquitination PhosphoSitePlus
K189 Ubiquitination PhosphoSitePlus
K199 Ubiquitination PhosphoSitePlus
K291 Ubiquitination PhosphoSitePlus
S292 Phosphorylation PhosphoSitePlus
C352 Methylation IEDB 31844290
K374 Ubiquitination PhosphoSitePlus
K383 Ubiquitination PhosphoSitePlus
K394 Ubiquitination PhosphoSitePlus
K397 Ubiquitination PhosphoSitePlus
K403 Ubiquitination PhosphoSitePlus
S419 Phosphorylation PhosphoSitePlus
K435 Ubiquitination PhosphoSitePlus
K441 Ubiquitination PhosphoSitePlus
K479 Ubiquitination PhosphoSitePlus
K497 Ubiquitination PhosphoSitePlus
K502 Ubiquitination PhosphoSitePlus
S621 Phosphorylation PhosphoSitePlus
K625 Ubiquitination PhosphoSitePlus
S628 Phosphorylation PhosphoSitePlus
K630 Ubiquitination PhosphoSitePlus
T636 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K502 E502 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S628 R628 Biomuta DOID:10283 / prostate cancer [ cosmic ]
K630 N630 Biomuta DOID:363 / uterine cancer [ cosmic ]