iPTMnet Report for Q6N021 (TET2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q6N021 / TET2_HUMAN
Protein Name Methylcytosine dioxygenase TET2
Gene Name Name: TET2
Synonyms:KIAA1546;ORFNames:Nbla00191;
Organism Homo sapiens (Human)

PRO ID PR:Q6N021
DAG View
PRO Name methylcytosine dioxygenase TET2 (human)
Definition A methylcytosine dioxygenase TET2 that is encoded in the genome of human.
Short Label hTET2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q6N021 (TET2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S15 Phosphorylation PhosphoSitePlus
S21 Phosphorylation PhosphoSitePlus
S38 Phosphorylation PhosphoSitePlus
K53 Acetylation PhosphoSitePlus
S75 Phosphorylation PhosphoSitePlus   UniProt 23186163
T97 Phosphorylation PhosphoSitePlus
S99 Phosphorylation Q13131 (PRKAA1) PhosphoSitePlus   RLIMS-P   Signor   UniProt 31187595, 30022161, 23186163, ...19690332
S102 Phosphorylation PhosphoSitePlus
K110 Acetylation PhosphoSitePlus
K111 Acetylation PhosphoSitePlus
S239 O-Glycosylation GlyGen 32938750
S334 Phosphorylation PhosphoSitePlus
R369 Methylation PhosphoSitePlus
S585 Phosphorylation PhosphoSitePlus
Y592 Phosphorylation IEDB 35494241
K655 Ubiquitination PhosphoSitePlus
S696 Phosphorylation PhosphoSitePlus
K747 Ubiquitination PhosphoSitePlus
S817 Phosphorylation PhosphoSitePlus
Y819 Phosphorylation PhosphoSitePlus
S820 Phosphorylation PhosphoSitePlus
T822 Phosphorylation PhosphoSitePlus
S833 O-Glycosylation GlyGen 26075789, 30379171, 32574038, ...35254053, 24394411, 34019948, 35289036
S835 O-Glycosylation GlyGen 34846842
S842 O-Glycosylation GlyGen 32574038
T859 Phosphorylation PhosphoSitePlus
K900 Ubiquitination PhosphoSitePlus
K948 Acetylation PhosphoSitePlus
S1015 O-Glycosylation GlyGen 32574038
T1096 O-Glycosylation GlyGen 32938750
S1099 Phosphorylation PhosphoSitePlus
S1107 Phosphorylation PhosphoSitePlus   UniProt 23186163, 19690332
S1109 Phosphorylation PhosphoSitePlus   UniProt 23186163
T1114 Phosphorylation PhosphoSitePlus
K1117 Acetylation PhosphoSitePlus
T1122 Phosphorylation IEDB   PhosphoSitePlus 24616531, 25880248, 32357974
K1299 Ubiquitination PhosphoSitePlus   UniProt 25557551
K1317 Acetylation PhosphoSitePlus
T1331 Phosphorylation PhosphoSitePlus
K1338 Ubiquitination PhosphoSitePlus
K1339 Acetylation PhosphoSitePlus
K1339 Ubiquitination PhosphoSitePlus
Y1345 Phosphorylation PhosphoSitePlus
S1449 Phosphorylation PhosphoSitePlus
T1463 Phosphorylation PhosphoSitePlus
K1478 Acetylation PhosphoSitePlus
S1480 O-Glycosylation GlyGen 30379171
S1481 O-Glycosylation GlyGen 26075789, 30379171, 32574038, ...35254053, 24394411, 34019948, 35289036
S1481 Phosphorylation PhosphoSitePlus
S1486 O-Glycosylation GlyGen 30379171
S1494 Phosphorylation PhosphoSitePlus
S1497 Phosphorylation PhosphoSitePlus
T1502 Phosphorylation PhosphoSitePlus
S1506 Phosphorylation PhosphoSitePlus
S1518 O-Glycosylation PhosphoSitePlus
S1559 Phosphorylation PhosphoSitePlus
Y1560 Phosphorylation PhosphoSitePlus
S1561 Phosphorylation PhosphoSitePlus
R1682 Methylation IEDB   PhosphoSitePlus   UniProt 24129315, 27503676
Y1902 Phosphorylation PhosphoSitePlus
Y1939 Phosphorylation PhosphoSitePlus
Y1964 Phosphorylation PhosphoSitePlus
T1975 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T97 Phosphorylation HPRD 19413330
S99 Phosphorylation HPRD 18669648
S1107 Phosphorylation HPRD 18669648, 19664994


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S15 I15 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S21 P21 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S75 C75 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T97 I97 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S99 T99 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic, cosmic, cosmic ]
K110 R110 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K110 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S239 F239 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S334 F334 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
R369 W369 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
S585 L585 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y592 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y592 S592 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S696 F696 Biomuta [ cosmic ]
Y819 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T822 P822 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S833 F833 Biomuta DOID:4159 / skin cancer [ cosmic ]
S835 * Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
S842 * Biomuta DOID:2531 / hematologic cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
T859 A859 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K900 N900 Biomuta DOID:9256 / colorectal cancer [ icgc ]
K948 R948 Biomuta DOID:3571 / liver cancer [ cosmic ]
S1107 * Biomuta DOID:1324 / lung cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
S1109 F1109 Biomuta DOID:1319 / brain cancer [ cosmic ]
T1122 A1122 Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
K1299 E1299 Biomuta DOID:1612 / breast cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
K1299 N1299 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K1299 Q1299 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K1299 T1299 Biomuta DOID:10534 / stomach cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
K1317 E1317 Biomuta DOID:1319 / brain cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ]
K1338 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K1338 T1338 Biomuta DOID:263 / kidney cancer [ cosmic ]
K1339 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y1345 S1345 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y1345 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S1449 Y1449 Biomuta DOID:1612 / breast cancer [ cosmic ]
T1463 S1463 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S1481 F1481 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1486 P1486 Biomuta DOID:263 / kidney cancer [ cosmic ]
S1486 * Biomuta DOID:1612 / breast cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
S1494 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S1497 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S1518 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y1560 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y1902 H1902 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y1902 S1902 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y1902 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y1964 H1964 Biomuta DOID:9256 / colorectal cancer [ cosmic ]