Protein Information

Cytoscape View


UniProt AC / UniProt ID Q6L8Q7 / PDE12_HUMAN
Protein Name 2',5'-phosphodiesterase 12 precursor
Gene Name Name: PDE12
Organism Homo sapiens (Human)

PRO ID PR:Q6L8Q7
DAG View
PRO Name 2',5'-phosphodiesterase 12 (human)
Definition A 2',5'-phosphodiesterase 12 that is encoded in the genome of human.
Short Label hPDE12
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q6L8Q7 (PDE12) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T16 Phosphorylation PhosphoSitePlus
S22 Phosphorylation PhosphoSitePlus
S50 Phosphorylation PhosphoSitePlus
S59 Phosphorylation PhosphoSitePlus
K61 Ubiquitination PhosphoSitePlus
S68 Phosphorylation PhosphoSitePlus
K84 Ubiquitination PhosphoSitePlus
K97 Ubiquitination PhosphoSitePlus
S98 Phosphorylation PhosphoSitePlus
S103 Phosphorylation PhosphoSitePlus
K199 Ubiquitination PhosphoSitePlus
K202 Ubiquitination PhosphoSitePlus
S214 Phosphorylation PhosphoSitePlus
S217 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
S219 Phosphorylation PhosphoSitePlus
S220 Phosphorylation PhosphoSitePlus
S222 Phosphorylation PhosphoSitePlus
S223 Phosphorylation PhosphoSitePlus
S224 Phosphorylation PhosphoSitePlus
R245 Methylation PhosphoSitePlus
K247 Ubiquitination PhosphoSitePlus
K377 Ubiquitination PhosphoSitePlus
K412 Ubiquitination PhosphoSitePlus
K417 Ubiquitination PhosphoSitePlus
K427 Acetylation PhosphoSitePlus
K427 Ubiquitination PhosphoSitePlus
K462 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T16 Phosphorylation HPRD 20068231
S22 Phosphorylation HPRD 20068231
S28 Phosphorylation HPRD 20068231
T30 Phosphorylation HPRD 20068231
S50 Phosphorylation HPRD 20068231
S59 Phosphorylation HPRD 20068231
S217 Phosphorylation HPRD 18669648, 20068231
S219 Phosphorylation HPRD 19415658
S220 Phosphorylation HPRD 18669648, 20068231, 18452278
S224 Phosphorylation HPRD 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S22 R22 Biomuta DOID:363 / uterine cancer [ tcga ]
S28 N28 Biomuta DOID:363 / uterine cancer [ tcga ]
S59 I59 Biomuta DOID:3571 / liver cancer [ icgc ]
K199 T199 Biomuta DOID:3571 / liver cancer [ icgc, tcga ] DOID:0070003 / blastoma [ cosmic ]
S217 F217 Biomuta DOID:3070 / malignant glioma [ tcga ]
K247 N247 Biomuta DOID:3571 / liver cancer [ icgc ]