iPTMnet Report for Q6L8Q7 (PDE12)
Protein Information
| UniProt AC / UniProt ID | Q6L8Q7 / PDE12_HUMAN |
| Protein Name | 2',5'-phosphodiesterase 12 precursor |
| Gene Name | Name: PDE12 |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q6L8Q7 |
| PRO Name | 2',5'-phosphodiesterase 12 (human) |
| Definition | A 2',5'-phosphodiesterase 12 that is encoded in the genome of human. |
| Short Label | hPDE12 |
| Category | organism-gene |
DAG ViewQ6L8Q7 (PDE12) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| T16 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S22 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S50 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S59 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K61 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S68 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K84 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K97 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S98 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S103 | Phosphorylation | score1 | PhosphoSitePlus | |||
| C180 | Methylation | score1 | IEDB | 31844290 | ||
| K199 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K202 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S214 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S217 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163, 20068231 | ||
| S219 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S220 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S222 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S223 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S224 | Phosphorylation | score1 | PhosphoSitePlus | |||
| R245 | Methylation | score1 | PhosphoSitePlus | |||
| K247 | Ubiquitination | score1 | PhosphoSitePlus | |||
| C268 | Methylation | score1 | IEDB | 31844290 | ||
| K377 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K390 | Acetylation | score1 | PhosphoSitePlus | |||
| K412 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K417 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K427 | Acetylation | score1 | PhosphoSitePlus | |||
| K427 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K462 | Ubiquitination | score1 | PhosphoSitePlus |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| T16 | Phosphorylation | score0 | HPRD | 20068231 | ||
| S22 | Phosphorylation | score0 | HPRD | 20068231 | ||
| S28 | Phosphorylation | score0 | HPRD | 20068231 | ||
| T30 | Phosphorylation | score0 | HPRD | 20068231 | ||
| S50 | Phosphorylation | score0 | HPRD | 20068231 | ||
| S59 | Phosphorylation | score0 | HPRD | 20068231 | ||
| S217 | Phosphorylation | score0 | HPRD | 18669648, 20068231 | ||
| S219 | Phosphorylation | score0 | HPRD | 19415658 | ||
| S220 | Phosphorylation | score0 | HPRD | 18669648, 20068231, 18452278 | ||
| S224 | Phosphorylation | score0 | HPRD | 18669648 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S22 | R22 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
| S28 | N28 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
| K199 | T199 | Biomuta | DOID:3571 / liver cancer [ cosmic, icgc ] | |
| S217 | F217 | Biomuta | DOID:1319 / brain cancer [ cosmic, icgc ] |
