iPTMnet Report for Q6KB66 (KRT80)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q6KB66 / K2C80_HUMAN
Protein Name Keratin, type II cytoskeletal 80
Gene Name Name: KRT80
Synonyms:KB20;
Organism Homo sapiens (Human)

PRO ID PR:Q6KB66
DAG View
PRO Name keratin, type II cytoskeletal 80 (human)
Definition A keratin, type II cytoskeletal 80 that is encoded in the genome of human.
Short Label hKRT80
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q6KB66 (KRT80) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T19 Phosphorylation PhosphoSitePlus
S23 Phosphorylation PhosphoSitePlus
S29 Phosphorylation PhosphoSitePlus
S45 Phosphorylation PhosphoSitePlus   UniProt 18669648
S51 Phosphorylation PhosphoSitePlus
T59 Phosphorylation PhosphoSitePlus
K71 Sumoylation PhosphoSitePlus
K71 Ubiquitination PhosphoSitePlus
K80 Ubiquitination PhosphoSitePlus
K88 Sumoylation PhosphoSitePlus
K93 Sumoylation PhosphoSitePlus
K93 Ubiquitination PhosphoSitePlus
K100 Ubiquitination PhosphoSitePlus
K190 Ubiquitination PhosphoSitePlus
K205 Ubiquitination PhosphoSitePlus
K225 Ubiquitination PhosphoSitePlus
K256 Ubiquitination PhosphoSitePlus
Y273 Phosphorylation PhosphoSitePlus
S276 Phosphorylation PhosphoSitePlus
K317 Ubiquitination PhosphoSitePlus
K322 Ubiquitination PhosphoSitePlus
K328 Ubiquitination PhosphoSitePlus
K342 Ubiquitination PhosphoSitePlus
K344 Ubiquitination PhosphoSitePlus
K356 Sumoylation PhosphoSitePlus
R364 Methylation PhosphoSitePlus
S396 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163
S398 Phosphorylation PhosphoSitePlus
T400 Phosphorylation PhosphoSitePlus
S403 Phosphorylation PhosphoSitePlus
S407 Phosphorylation PhosphoSitePlus
S416 Phosphorylation PhosphoSitePlus
S419 Phosphorylation PhosphoSitePlus
K420 Ubiquitination PhosphoSitePlus
S423 Phosphorylation PhosphoSitePlus
S429 Phosphorylation PhosphoSitePlus
K435 Sumoylation PhosphoSitePlus
T437 Phosphorylation PhosphoSitePlus
Y443 Phosphorylation PhosphoSitePlus
S445 Phosphorylation PhosphoSitePlus
S448 Phosphorylation PhosphoSitePlus
S451 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S45 Phosphorylation HPRD 18669648, 18212344
S396 Phosphorylation HPRD 18691976, 18669648, 20068231
T400 Phosphorylation HPRD 20068231
S403 Phosphorylation HPRD 20068231
S407 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S45 Phosphorylation HPRD 18669648, 18212344
S396 Phosphorylation HPRD 18691976, 18669648, 20068231
S398 Phosphorylation PhosphoSitePlus
T400 Phosphorylation HPRD 20068231
S403 Phosphorylation HPRD 20068231
S407 Phosphorylation HPRD 20068231
S414 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S29 L29 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K256 N256 Biomuta DOID:1324 / lung cancer [ cosmic ]
S276 N276 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
K317 R317 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K328 M328 Biomuta DOID:263 / kidney cancer [ cosmic ]
K342 N342 Biomuta DOID:1324 / lung cancer [ cosmic ]
R364 H364 Biomuta DOID:1319 / brain cancer [ icgc ]
T400 I400 Biomuta DOID:3571 / liver cancer [ cosmic ]
S423 F423 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S445 L445 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ]