iPTMnet Report for Q6K0P9 (PYHIN1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q6K0P9 / IFIX_HUMAN
Protein Name Pyrin and HIN domain-containing protein 1
Gene Name Name: PYHIN1
Synonyms:IFIX;
Organism Homo sapiens (Human)

PRO ID PR:Q6K0P9
DAG View
PRO Name pyrin and HIN domain-containing protein 1 (human)
Definition A pyrin and HIN domain-containing protein 1 that is encoded in the genome of human.
Short Label hPYHIN1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q6K0P9 (PYHIN1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y5 Phosphorylation PhosphoSitePlus
Y20 Phosphorylation PhosphoSitePlus
K40 Acetylation PhosphoSitePlus
K45 Acetylation PhosphoSitePlus
K110 Acetylation PhosphoSitePlus
K138 Acetylation PhosphoSitePlus
S143 Phosphorylation PhosphoSitePlus
K207 Ubiquitination PhosphoSitePlus
Y228 Phosphorylation PhosphoSitePlus
S386 Phosphorylation PhosphoSitePlus
S390 Phosphorylation PhosphoSitePlus
S425 Phosphorylation PhosphoSitePlus
K453 Ubiquitination PhosphoSitePlus
K454 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
K90 Acetylation PhosphoSitePlus
K96 Acetylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T429 Phosphorylation PhosphoSitePlus
S447 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K40 N40 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K138 Q138 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S143 F143 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S386 P386 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S390 A390 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S390 L390 Biomuta DOID:4159 / skin cancer [ cosmic ]
T429 A429 Biomuta DOID:10534 / stomach cancer [ cosmic ]