iPTMnet Report for Q6ISB3 (GRHL2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q6ISB3 / GRHL2_HUMAN
Protein Name Grainyhead-like protein 2 homolog
Gene Name Name: GRHL2
Synonyms:BOM,TFCP2L3;
Organism Homo sapiens (Human)

PRO ID PR:Q6ISB3
DAG View
PRO Name grainyhead-like protein 2 homolog (human)
Definition A grainyhead-like protein 2 that is encoded in the genome of human.
Short Label hGRHL2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q6ISB3 (GRHL2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S53 Phosphorylation PhosphoSitePlus
S60 Phosphorylation PhosphoSitePlus
Y68 Phosphorylation PhosphoSitePlus
Y70 Phosphorylation PhosphoSitePlus
Y71 Phosphorylation PhosphoSitePlus
S81 Phosphorylation PhosphoSitePlus
S88 Phosphorylation PhosphoSitePlus
S125 Phosphorylation PhosphoSitePlus
S147 O-Glycosylation GlyGen 32574038
S153 O-Glycosylation GlyGen 29485866, 30379171, 32574038, ...35132862
T164 Phosphorylation PhosphoSitePlus
S210 Phosphorylation PhosphoSitePlus
T211 Phosphorylation PhosphoSitePlus
S214 Phosphorylation PhosphoSitePlus
T215 Phosphorylation PhosphoSitePlus
S217 Phosphorylation PhosphoSitePlus
S230 Phosphorylation PhosphoSitePlus
S232 Phosphorylation PhosphoSitePlus
R401 Methylation PhosphoSitePlus
K453 Acetylation PhosphoSitePlus
T500 Phosphorylation PhosphoSitePlus
S508 Phosphorylation PhosphoSitePlus
K512 Acetylation PhosphoSitePlus
K528 Acetylation PhosphoSitePlus
K531 Acetylation PhosphoSitePlus
K536 Acetylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S60 G60 Biomuta DOID:1324 / lung cancer [ cosmic ]
S60 N60 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S81 F81 Biomuta DOID:4159 / skin cancer [ cosmic ]
S81 Y81 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S147 F147 Biomuta [ cosmic ] DOID:4362 / cervical cancer [ cosmic ]
T211 P211 Biomuta DOID:1324 / lung cancer [ cosmic ]
S217 N217 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S232 L232 Biomuta DOID:4362 / cervical cancer [ cosmic ]
K536 N536 Biomuta DOID:4606 / bile duct cancer [ cosmic ]