iPTMnet Report for Q6IQ55 (TTBK2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q6IQ55 / TTBK2_HUMAN
Protein Name Tau-tubulin kinase 2
Gene Name Name: TTBK2
Synonyms:KIAA0847;
Organism Homo sapiens (Human)

PRO ID PR:Q6IQ55
DAG View
PRO Name tau-tubulin kinase 2 (human)
Definition A tau-tubulin kinase 2 that is encoded in the genome of human.
Short Label hTTBK2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q6IQ55 (TTBK2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K70 Sumoylation PhosphoSitePlus
S211 Phosphorylation PhosphoSitePlus
Y242 Phosphorylation PhosphoSitePlus
T314 Phosphorylation PhosphoSitePlus
T322 Phosphorylation PhosphoSitePlus
S371 Phosphorylation PhosphoSitePlus
T402 Phosphorylation PhosphoSitePlus
S407 Phosphorylation PhosphoSitePlus
S428 Phosphorylation PhosphoSitePlus
T431 Phosphorylation PhosphoSitePlus
S445 Phosphorylation PhosphoSitePlus   UniProt 23186163
S448 Phosphorylation PhosphoSitePlus
T463 Phosphorylation PhosphoSitePlus
K476 Ubiquitination PhosphoSitePlus
S479 Phosphorylation PhosphoSitePlus
S499 Phosphorylation PhosphoSitePlus
T613 Phosphorylation PhosphoSitePlus
S614 Phosphorylation PhosphoSitePlus
S621 Phosphorylation PhosphoSitePlus
S751 Phosphorylation PhosphoSitePlus
S781 Phosphorylation PhosphoSitePlus
S786 Phosphorylation PhosphoSitePlus   UniProt 21406692
S794 Phosphorylation PhosphoSitePlus
S817 O-Glycosylation GlyGen 26598643
S817 Phosphorylation PhosphoSitePlus
T819 O-Glycosylation GlyGen 26598643
T820 O-Glycosylation GlyGen 26598643
T828 Phosphorylation PhosphoSitePlus
T830 Phosphorylation PhosphoSitePlus
K845 Acetylation PhosphoSitePlus
K877 Acetylation PhosphoSitePlus
S879 Phosphorylation PhosphoSitePlus
K880 Acetylation IEDB 34357683
S960 Phosphorylation PhosphoSitePlus
S963 Phosphorylation PhosphoSitePlus
K985 Ubiquitination PhosphoSitePlus
S1039 Phosphorylation PhosphoSitePlus
S1042 Phosphorylation PhosphoSitePlus
S1103 Phosphorylation PhosphoSitePlus   UniProt 23186163
T1139 Phosphorylation PhosphoSitePlus
S1143 Phosphorylation PhosphoSitePlus
S1152 Phosphorylation PhosphoSitePlus
S1154 Phosphorylation PhosphoSitePlus
S1157 Phosphorylation PhosphoSitePlus
S1240 Phosphorylation PhosphoSitePlus
S1243 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T478 Phosphorylation HPRD 20068231
S479 Phosphorylation HPRD 20068231
S499 Phosphorylation HPRD 20068231
S786 Phosphorylation HPRD 19413330


Q6IQ55 (TTBK2) as PTM Enzyme



Substrate Site Score Source PMID
O00139 (KIF2A) S135 PhosphoSitePlus 26323690
Q7L0J3 (SV2A) S42 PhosphoSitePlus 25673844
Q7L0J3 (SV2A) S45 PhosphoSitePlus 25673844
Q7L0J3 (SV2A) S47 PhosphoSitePlus 25673844
Q7L0J3 (SV2A) S80 PhosphoSitePlus 25673844
Q7L0J3 (SV2A) S81 PhosphoSitePlus 25673844
Q7L0J3 (SV2A) T84 PhosphoSitePlus 25673844


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S499 F499 Biomuta DOID:4159 / skin cancer [ cosmic ]
S781 N781 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S794 R794 Biomuta DOID:184 / bone cancer [ cosmic ]
K877 T877 Biomuta DOID:363 / uterine cancer [ icgc ]
S879 F879 Biomuta DOID:4159 / skin cancer [ cosmic ]
K880 M880 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1243 N1243 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]