iPTMnet Report for Q6IQ26 (DENND5A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q6IQ26 / DEN5A_HUMAN
Protein Name DENN domain-containing protein 5A
Gene Name Name: DENND5A
Synonyms:KIAA1091,RAB6IP1;
Organism Homo sapiens (Human)

PRO ID PR:Q6IQ26
DAG View
PRO Name DENN domain-containing protein 5A (human)
Definition A DENN domain-containing protein 5A that is encoded in the genome of human.
Short Label hDENND5A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q6IQ26 (DENND5A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S10 Phosphorylation PhosphoSitePlus
S13 Phosphorylation PhosphoSitePlus
S52 Phosphorylation PhosphoSitePlus
T123 Phosphorylation PhosphoSitePlus
S193 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
Y194 Phosphorylation PhosphoSitePlus
S455 Phosphorylation PhosphoSitePlus
S459 Phosphorylation PhosphoSitePlus
Y460 Phosphorylation PhosphoSitePlus
T468 Phosphorylation PhosphoSitePlus
K477 Ubiquitination PhosphoSitePlus
T479 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
S482 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
K485 Ubiquitination PhosphoSitePlus
K557 Ubiquitination PhosphoSitePlus
T618 Phosphorylation PhosphoSitePlus
K686 Ubiquitination PhosphoSitePlus
Y719 Phosphorylation PhosphoSitePlus
S739 Phosphorylation PhosphoSitePlus
T833 Phosphorylation PhosphoSitePlus
S834 Phosphorylation PhosphoSitePlus
S836 Phosphorylation PhosphoSitePlus
S838 Phosphorylation PhosphoSitePlus
S846 Phosphorylation PhosphoSitePlus
S851 Phosphorylation PhosphoSitePlus
S854 Phosphorylation PhosphoSitePlus
S855 Phosphorylation PhosphoSitePlus
K878 Ubiquitination PhosphoSitePlus
K1050 Ubiquitination PhosphoSitePlus
T1079 Phosphorylation PhosphoSitePlus
S1085 Phosphorylation PhosphoSitePlus
S1087 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1096 Phosphorylation PhosphoSitePlus   UniProt 23186163
K1100 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S193 Phosphorylation HPRD 18669648, 20058876
T725 Phosphorylation HPRD 17081983


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T123 A123 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T468 N468 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S739 F739 Biomuta DOID:4159 / skin cancer [ cosmic ]
S834 * Biomuta DOID:363 / uterine cancer [ cosmic ]
S851 Y851 Biomuta DOID:1319 / brain cancer [ icgc ]
K1050 N1050 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:1319 / brain cancer [ cosmic, icgc ]
T1079 P1079 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1085 P1085 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]