Protein Information

Cytoscape View


UniProt AC / UniProt ID Q6DT37 / MRCKG_HUMAN
Protein Name Serine/threonine-protein kinase MRCK gamma
Gene Name Name: CDC42BPG
Synonyms:DMPK2;
Organism Homo sapiens (Human)

PRO ID PR:Q6DT37
DAG View
PRO Name serine/threonine-protein kinase MRCK gamma (human)
Definition A serine/threonine-protein kinase MRCK gamma that is encoded in the genome of human.
Short Label hCDC42BPG
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q6DT37 (CDC42BPG) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S46 Phosphorylation PhosphoSitePlus
K75 Ubiquitination PhosphoSitePlus
T113 Phosphorylation PhosphoSitePlus
K125 Ubiquitination PhosphoSitePlus
T222 Phosphorylation PhosphoSitePlus
T234 Phosphorylation PhosphoSitePlus
S239 Phosphorylation PhosphoSitePlus
S480 Phosphorylation PhosphoSitePlus
S646 Phosphorylation PhosphoSitePlus
K663 Ubiquitination PhosphoSitePlus
S740 Phosphorylation PhosphoSitePlus
S747 Phosphorylation PhosphoSitePlus
S817 Phosphorylation PhosphoSitePlus
S851 Phosphorylation PhosphoSitePlus
K875 Ubiquitination PhosphoSitePlus
S888 Phosphorylation PhosphoSitePlus
S1121 Phosphorylation PhosphoSitePlus
K1172 Ubiquitination PhosphoSitePlus
K1200 Methylation PhosphoSitePlus
K1385 Ubiquitination PhosphoSitePlus
S1462 Phosphorylation PhosphoSitePlus
R1473 Methylation PhosphoSitePlus
S1482 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1484 Phosphorylation PhosphoSitePlus
S1492 Phosphorylation PhosphoSitePlus
S1495 Phosphorylation PhosphoSitePlus
S1514 Phosphorylation PhosphoSitePlus
S1515 Phosphorylation PhosphoSitePlus
S1519 Phosphorylation PhosphoSitePlus
S1524 Phosphorylation PhosphoSitePlus
S1540 Phosphorylation PhosphoSitePlus
S1544 Phosphorylation PhosphoSitePlus
S1550 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S46 T46 Biomuta DOID:184 / bone cancer [ icgc ]
T234 M234 Biomuta DOID:1793 / pancreatic cancer [ icgc, tcga ] DOID:10283 / prostate cancer [ cosmic ]
S740 L740 Biomuta DOID:10534 / stomach cancer [ tcga ]
S851 T851 Biomuta DOID:2531 / hematologic cancer [ icgc ]
K1200 Q1200 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
K1200 E1200 Biomuta DOID:2531 / hematologic cancer [ icgc ]
K1385 N1385 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S1492 C1492 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1495 I1495 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
S1544 Y1544 Biomuta DOID:1324 / lung cancer [ tcga ]