iPTMnet Report for Q6DN90 (IQSEC1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q6DN90 / IQEC1_HUMAN
Protein Name IQ motif and SEC7 domain-containing protein 1
Gene Name Name: IQSEC1
Synonyms:ARFGEP100,BRAG2;
Organism Homo sapiens (Human)

PRO ID PR:Q6DN90
DAG View
PRO Name IQ motif and SEC7 domain-containing protein 1 (human)
Definition An IQ motif and SEC7 domain-containing protein 1 that is encoded in the genome of human.
Short Label hIQSEC1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q6DN90 (IQSEC1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y69 Phosphorylation PhosphoSitePlus
S87 Phosphorylation PhosphoSitePlus
T88 Phosphorylation PhosphoSitePlus
S89 Phosphorylation PhosphoSitePlus   UniProt 23186163
S105 Phosphorylation PhosphoSitePlus   UniProt 23186163
S107 Phosphorylation PhosphoSitePlus   UniProt 23186163
S109 Phosphorylation PhosphoSitePlus
K152 Ubiquitination PhosphoSitePlus
S167 Phosphorylation PhosphoSitePlus
S180 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 18669648, ...24275569
K195 Ubiquitination PhosphoSitePlus
T200 Phosphorylation PhosphoSitePlus
S211 Phosphorylation PhosphoSitePlus
K224 Ubiquitination PhosphoSitePlus
S225 Phosphorylation PhosphoSitePlus
K248 Ubiquitination PhosphoSitePlus
S253 Phosphorylation PhosphoSitePlus   UniProt 24275569
C260 Methylation IEDB 31844290
S262 Phosphorylation PhosphoSitePlus
T265 Phosphorylation PhosphoSitePlus
Y343 Phosphorylation PhosphoSitePlus
T362 Phosphorylation phospho.ELM   PhosphoSitePlus 15302935
S364 Phosphorylation PhosphoSitePlus
S386 Phosphorylation PhosphoSitePlus
S400 Phosphorylation PhosphoSitePlus
S410 Phosphorylation PhosphoSitePlus
S417 Phosphorylation PhosphoSitePlus
S424 Phosphorylation PhosphoSitePlus
Y465 Phosphorylation PhosphoSitePlus
K502 Ubiquitination PhosphoSitePlus
S512 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692, ...24275569
S515 Phosphorylation PhosphoSitePlus   UniProt 23186163
K684 Ubiquitination PhosphoSitePlus
R687 Methylation PhosphoSitePlus
K852 Methylation PhosphoSitePlus
S886 Phosphorylation PhosphoSitePlus
S892 Phosphorylation PhosphoSitePlus   UniProt 23186163
S897 Phosphorylation PhosphoSitePlus
T901 Phosphorylation PhosphoSitePlus
S910 Phosphorylation PhosphoSitePlus
Y911 Phosphorylation PhosphoSitePlus   UniProt 24275569
S913 Phosphorylation PhosphoSitePlus
K918 Methylation PhosphoSitePlus
S923 Phosphorylation PhosphoSitePlus
S924 Phosphorylation PhosphoSitePlus   UniProt 24275569
S925 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
S939 Phosphorylation PhosphoSitePlus
S940 Phosphorylation PhosphoSitePlus
S943 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S180 Phosphorylation HPRD 19413330, 18669648
T362 Phosphorylation HPRD 15302935
Y407 Phosphorylation HPRD 20068231
S410 Phosphorylation HPRD 20068231
S512 Phosphorylation HPRD 20166139, 18669648, 20058876, ...20068231
S515 Phosphorylation HPRD 20068231
S925 Phosphorylation HPRD 20058876


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S87 L87 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S105 L105 Biomuta DOID:4159 / skin cancer [ cosmic ]
C260 Y260 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T265 A265 Biomuta DOID:184 / bone cancer [ cosmic ]
S417 I417 Biomuta DOID:1324 / lung cancer [ cosmic ]
R687 * Biomuta DOID:10534 / stomach cancer [ cosmic ]
S913 R913 Biomuta DOID:3571 / liver cancer [ cosmic ]
S925 F925 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]