iPTMnet Report for Q6AI08 (HEATR6)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q6AI08 / HEAT6_HUMAN
Protein Name HEAT repeat-containing protein 6
Gene Name Name: HEATR6
Synonyms:ABC1;
Organism Homo sapiens (Human)

PRO ID PR:Q6AI08
DAG View
PRO Name HEAT repeat-containing protein 6 (human)
Definition A HEAT repeat-containing protein 6 that is encoded in the genome of human.
Short Label hHEATR6
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q6AI08 (HEATR6) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S9 Phosphorylation PhosphoSitePlus
Y157 Phosphorylation PhosphoSitePlus
K267 Ubiquitination PhosphoSitePlus
K300 Ubiquitination PhosphoSitePlus
T312 Phosphorylation PhosphoSitePlus
S336 Phosphorylation PhosphoSitePlus   UniProt 23186163
S337 Phosphorylation PhosphoSitePlus   UniProt 23186163
T346 Phosphorylation PhosphoSitePlus
S395 Phosphorylation HPRD   PhosphoSitePlus 19651622
S396 Phosphorylation HPRD   PhosphoSitePlus 19651622
S397 Phosphorylation HPRD   PhosphoSitePlus 19651622
S399 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19651622, 23186163
S402 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19651622, 23186163
S410 Phosphorylation PhosphoSitePlus
K411 Ubiquitination PhosphoSitePlus
Y440 Phosphorylation PhosphoSitePlus
Y442 Phosphorylation PhosphoSitePlus
K556 Ubiquitination PhosphoSitePlus
K568 Acetylation PhosphoSitePlus
K629 Ubiquitination PhosphoSitePlus
S635 Phosphorylation PhosphoSitePlus
S640 Phosphorylation HPRD   PhosphoSitePlus 18691976
S642 Phosphorylation HPRD   PhosphoSitePlus 18691976, 19664995
S643 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 18691976, 23186163, ...19664994, 18669648, 18707149, 19690332, 20068231
S659 Phosphorylation PhosphoSitePlus
S676 Phosphorylation PhosphoSitePlus
S680 Phosphorylation PhosphoSitePlus
S685 Phosphorylation PhosphoSitePlus
S913 Phosphorylation PhosphoSitePlus
K921 Acetylation PhosphoSitePlus
S962 Phosphorylation HPRD   PhosphoSitePlus 20058876
T963 Phosphorylation HPRD   PhosphoSitePlus 20058876
K1029 Ubiquitination PhosphoSitePlus
T1119 Phosphorylation PhosphoSitePlus
S1124 Phosphorylation PhosphoSitePlus
K1137 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S336 Y336 Biomuta DOID:3571 / liver cancer [ cosmic ]
S399 T399 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K568 N568 Biomuta DOID:363 / uterine cancer [ cosmic ]
K629 I629 Biomuta DOID:4159 / skin cancer [ cosmic ]
S659 F659 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S913 L913 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S1124 R1124 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S1124 N1124 Biomuta DOID:4606 / bile duct cancer [ cosmic ]