iPTMnet Report for Q68D51 (DENND2C)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q68D51 / DEN2C_HUMAN
Protein Name DENN domain-containing protein 2C
Gene Name Name: DENND2C
Organism Homo sapiens (Human)

PRO ID PR:Q68D51
DAG View
PRO Name DENN domain-containing protein 2C (human)
Definition A DENN domain-containing protein 2C that is encoded in the genome of human.
Short Label hDENND2C
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q68D51 (DENND2C) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S171 O-Glycosylation GlyGen 29237092, 30620550
S183 Phosphorylation PhosphoSitePlus
Y185 Phosphorylation PhosphoSitePlus
S190 Phosphorylation PhosphoSitePlus
Y195 Phosphorylation PhosphoSitePlus
S221 Phosphorylation PhosphoSitePlus
S223 Phosphorylation PhosphoSitePlus
K262 Ubiquitination PhosphoSitePlus
S271 Phosphorylation PhosphoSitePlus
S285 Phosphorylation PhosphoSitePlus
T287 Phosphorylation PhosphoSitePlus
S370 O-Glycosylation GlyGen 29237092, 30620550
S449 Phosphorylation PhosphoSitePlus
S504 Phosphorylation PhosphoSitePlus
S677 Phosphorylation PhosphoSitePlus
C768 Methylation IEDB 31844290
S920 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S190 I190 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S271 F271 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T287 M287 Biomuta DOID:9256 / colorectal cancer [ icgc ] DOID:5041 / esophageal cancer [ cosmic ]