iPTMnet Report for Q68CZ2 (TNS3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q68CZ2 / TENS3_HUMAN
Protein Name Tensin-3
Gene Name Name: TNS3
Synonyms:TEM6,TENS1,TPP;
Organism Homo sapiens (Human)

PRO ID PR:Q68CZ2
DAG View
PRO Name tensin-3 (human)
Definition A tensin-3 that is encoded in the genome of human.
Short Label hTNS3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q68CZ2 (TNS3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y11 Phosphorylation IEDB 32387766
K44 Acetylation PhosphoSitePlus
K57 Ubiquitination PhosphoSitePlus
K63 Ubiquitination PhosphoSitePlus
K67 Ubiquitination PhosphoSitePlus
K142 Ubiquitination PhosphoSitePlus
K147 Ubiquitination PhosphoSitePlus
K157 Ubiquitination PhosphoSitePlus
Y204 Phosphorylation PhosphoSitePlus
K237 Ubiquitination PhosphoSitePlus
K243 Ubiquitination PhosphoSitePlus
K284 Ubiquitination PhosphoSitePlus
S299 Phosphorylation PhosphoSitePlus
Y321 Phosphorylation PhosphoSitePlus
T323 Phosphorylation UniProt 26166433
T324 Phosphorylation PhosphoSitePlus
S332 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15951569, 18669648
Y333 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107, 18669648, 16497976
S337 Phosphorylation PhosphoSitePlus
T345 Phosphorylation PhosphoSitePlus
S352 Phosphorylation PhosphoSitePlus
Y354 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107, 16497976
S361 Phosphorylation PhosphoSitePlus   UniProt 24275569
S383 Phosphorylation PhosphoSitePlus
T405 Phosphorylation PhosphoSitePlus
T413 Phosphorylation PhosphoSitePlus
S418 Phosphorylation PhosphoSitePlus
K422 Ubiquitination PhosphoSitePlus
S440 Phosphorylation PhosphoSitePlus   UniProt 24275569
K442 Ubiquitination PhosphoSitePlus
K450 Acetylation PhosphoSitePlus
Y451 Phosphorylation PhosphoSitePlus
K471 Ubiquitination PhosphoSitePlus
S492 Phosphorylation PhosphoSitePlus
S516 Phosphorylation PhosphoSitePlus   UniProt 24275569
S519 Phosphorylation PhosphoSitePlus
Y549 Phosphorylation PhosphoSitePlus
K561 Ubiquitination PhosphoSitePlus
K569 Ubiquitination PhosphoSitePlus
S571 Phosphorylation PhosphoSitePlus
S573 Phosphorylation PhosphoSitePlus
Y579 Phosphorylation PhosphoSitePlus
S582 Phosphorylation PhosphoSitePlus
S583 Phosphorylation PhosphoSitePlus
Y584 Phosphorylation PhosphoSitePlus
S585 Phosphorylation PhosphoSitePlus
T586 Phosphorylation PhosphoSitePlus
T588 Phosphorylation PhosphoSitePlus
Y601 Phosphorylation PhosphoSitePlus
S602 Phosphorylation PhosphoSitePlus
R628 Methylation PhosphoSitePlus
T632 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 16964243
R635 Methylation PhosphoSitePlus
T637 Phosphorylation PhosphoSitePlus
S638 Phosphorylation PhosphoSitePlus
R640 Methylation PhosphoSitePlus
R645 Methylation PhosphoSitePlus
S649 Phosphorylation PhosphoSitePlus   UniProt 20068231
S660 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S662 Phosphorylation PhosphoSitePlus
K663 Ubiquitination PhosphoSitePlus
S683 Phosphorylation PhosphoSitePlus
T684 Phosphorylation PhosphoSitePlus
S687 Phosphorylation PhosphoSitePlus
S690 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 15302935
T692 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S698 Phosphorylation PhosphoSitePlus
S725 Phosphorylation PhosphoSitePlus
S732 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
S735 Phosphorylation PhosphoSitePlus   UniProt 20068231
T749 Phosphorylation PhosphoSitePlus
S762 Phosphorylation PhosphoSitePlus
S763 Phosphorylation PhosphoSitePlus
R771 Methylation PhosphoSitePlus
K774 Ubiquitination PhosphoSitePlus
S776 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 15951569, 18669648, ...24275569, 20068231
Y780 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15951569, 18669648, 20068231
S791 Phosphorylation PhosphoSitePlus
K797 Methylation PhosphoSitePlus
Y802 Phosphorylation PhosphoSitePlus
S811 Phosphorylation PhosphoSitePlus   UniProt 20068231, 24275569
K816 Ubiquitination PhosphoSitePlus
T818 Phosphorylation PhosphoSitePlus
T820 Phosphorylation PhosphoSitePlus
Y823 Phosphorylation PhosphoSitePlus
S836 Phosphorylation PhosphoSitePlus
S837 Phosphorylation PhosphoSitePlus
K838 Ubiquitination PhosphoSitePlus
S840 Phosphorylation PhosphoSitePlus
S843 Phosphorylation PhosphoSitePlus
T844 Phosphorylation PhosphoSitePlus
S850 Phosphorylation PhosphoSitePlus
T853 Phosphorylation PhosphoSitePlus
Y855 Phosphorylation PhosphoSitePlus
T858 Phosphorylation PhosphoSitePlus
S866 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S873 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S874 Phosphorylation PhosphoSitePlus
S877 Phosphorylation PhosphoSitePlus
S887 Phosphorylation PhosphoSitePlus
S899 Phosphorylation PhosphoSitePlus
S901 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 24275569
T917 Phosphorylation PhosphoSitePlus
S919 Phosphorylation PhosphoSitePlus
S926 Phosphorylation PhosphoSitePlus
S941 Phosphorylation PhosphoSitePlus
S942 Phosphorylation PhosphoSitePlus
S943 Phosphorylation PhosphoSitePlus
S944 Phosphorylation PhosphoSitePlus
S952 Phosphorylation PhosphoSitePlus
S953 Phosphorylation PhosphoSitePlus
S959 Phosphorylation PhosphoSitePlus
S963 Phosphorylation PhosphoSitePlus
T967 Phosphorylation PhosphoSitePlus
S969 Phosphorylation PhosphoSitePlus
S972 Phosphorylation PhosphoSitePlus
S976 Phosphorylation PhosphoSitePlus
S982 Phosphorylation PhosphoSitePlus
S1113 Phosphorylation PhosphoSitePlus
S1115 Phosphorylation PhosphoSitePlus
S1118 Phosphorylation PhosphoSitePlus
S1119 Phosphorylation PhosphoSitePlus
S1122 Phosphorylation PhosphoSitePlus
S1123 Phosphorylation PhosphoSitePlus
S1126 Phosphorylation PhosphoSitePlus
S1128 Phosphorylation PhosphoSitePlus
T1129 Phosphorylation PhosphoSitePlus
S1131 Phosphorylation PhosphoSitePlus
K1143 Ubiquitination PhosphoSitePlus
S1145 Phosphorylation PhosphoSitePlus
S1149 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231, ...24275569
S1154 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231, 24275569
K1158 Ubiquitination PhosphoSitePlus
K1163 Ubiquitination PhosphoSitePlus
K1170 Ubiquitination PhosphoSitePlus
Y1173 Phosphorylation P12931 (SRC) PhosphoSitePlus   Signor 19732724
K1174 Ubiquitination PhosphoSitePlus
K1187 Ubiquitination PhosphoSitePlus
K1189 Ubiquitination PhosphoSitePlus
S1193 Phosphorylation PhosphoSitePlus
S1199 Phosphorylation PhosphoSitePlus
S1201 Phosphorylation PhosphoSitePlus
Y1206 Phosphorylation P12931 (SRC) PhosphoSitePlus   Signor 19732724
T1214 Phosphorylation PhosphoSitePlus
S1218 Phosphorylation PhosphoSitePlus
K1224 Ubiquitination PhosphoSitePlus
K1225 Ubiquitination PhosphoSitePlus
K1244 Ubiquitination PhosphoSitePlus
K1249 Ubiquitination PhosphoSitePlus
S1252 Phosphorylation PhosphoSitePlus
Y1256 Phosphorylation P12931 (SRC) PhosphoSitePlus   Signor 19732724
S1259 Phosphorylation PhosphoSitePlus
T1261 Phosphorylation PhosphoSitePlus
S1293 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
T1337 Phosphorylation PhosphoSitePlus
K1392 Ubiquitination PhosphoSitePlus
K1398 Ubiquitination PhosphoSitePlus
K1406 Ubiquitination PhosphoSitePlus
S1441 Phosphorylation IEDB   PhosphoSitePlus   UniProt 32897882, 32387766, 23186163
Site PTM Type PTM Enzyme Score Source PMID
S332 Phosphorylation HPRD 18669648, 20068231
Y333 Phosphorylation HPRD 18669648
Y601 Phosphorylation HPRD 19901323
T632 Phosphorylation HPRD 18669648, 18212344
S649 Phosphorylation HPRD 20068231
S660 Phosphorylation HPRD 19651622, 20166139, 18669648, ...20068231
S662 Phosphorylation HPRD 20068231
S690 Phosphorylation HPRD 18669648, 20068231
T692 Phosphorylation HPRD 18669648
S730 Phosphorylation HPRD 20068231
S732 Phosphorylation HPRD 20068231
S735 Phosphorylation HPRD 20068231
S776 Phosphorylation HPRD 19901323, 17389395, 18212344, ...18767875, 19651622, 18669648, 20166139, 20068231
Y780 Phosphorylation HPRD 19413330, 19901323, 17389395, ...19651622, 18669648, 20068231
S791 Phosphorylation HPRD 20068231
Y802 Phosphorylation HPRD 19901323
S811 Phosphorylation HPRD 20068231
Y823 Phosphorylation HPRD 20068231
S850 Phosphorylation HPRD 19413330
S866 Phosphorylation HPRD 18669648
S873 Phosphorylation HPRD 18669648, 20068231
S901 Phosphorylation HPRD 18669648
S952 Phosphorylation HPRD 20068231
S963 Phosphorylation HPRD 20068231
T967 Phosphorylation HPRD 20068231
S969 Phosphorylation HPRD 19664994
T978 Phosphorylation HPRD 20068231
S1145 Phosphorylation HPRD 20068231
S1149 Phosphorylation HPRD 19651622, 18669648, 19664994, ...20068231
S1154 Phosphorylation HPRD 19413330, 19651622, 18669648, ...20068231
S1293 Phosphorylation HPRD 18669648, 20068231
S1441 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K142 T142 Biomuta DOID:10283 / prostate cancer [ icgc ]
K147 N147 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K157 R157 Biomuta DOID:363 / uterine cancer [ icgc ]
Y204 C204 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K284 Q284 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S352 I352 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S361 N361 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K442 T442 Biomuta DOID:363 / uterine cancer [ icgc ]
K442 N442 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S516 R516 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S519 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S573 F573 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
S582 N582 Biomuta DOID:1319 / brain cancer [ cosmic ]
T632 I632 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
T637 I637 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
T637 S637 Biomuta DOID:1324 / lung cancer [ cosmic ]
S649 T649 Biomuta DOID:1319 / brain cancer [ cosmic ]
S660 C660 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S687 F687 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S690 L690 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T692 S692 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y802 C802 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S837 G837 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S837 N837 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S843 L843 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
Y855 H855 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S874 C874 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S899 P899 Biomuta DOID:363 / uterine cancer [ icgc ]
S901 N901 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
T917 M917 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S941 G941 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S944 F944 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S952 I952 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S959 A959 Biomuta DOID:4159 / skin cancer [ cosmic ]
S959 F959 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S963 C963 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T967 I967 Biomuta DOID:3571 / liver cancer [ cosmic ]
S976 C976 Biomuta DOID:4159 / skin cancer [ cosmic ]
S976 F976 Biomuta [ cosmic ]
S982 Y982 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S1119 N1119 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1122 C1122 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S1128 G1128 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S1149 L1149 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K1163 T1163 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K1163 R1163 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
Y1173 F1173 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S1199 I1199 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S1218 L1218 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K1224 E1224 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
T1337 I1337 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
K1398 E1398 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1441 F1441 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:4362 / cervical cancer [ cosmic, icgc ]