Protein Information

Cytoscape View


UniProt AC / UniProt ID Q684P5 / RPGP2_HUMAN
Protein Name Rap1 GTPase-activating protein 2
Gene Name Name: RAP1GAP2
Synonyms:GARNL4,KIAA1039,RAP1GA2;
Organism Homo sapiens (Human)

PRO ID PR:Q684P5
DAG View
PRO Name Rap1 GTPase-activating protein 2 (human)
Definition A Rap1 GTPase-activating protein 2 that is encoded in the genome of human.
Short Label hRAP1GAP2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q684P5 (RAP1GAP2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S7 Phosphorylation Q13976 (PRKG1) PhosphoSitePlus   RLIMS-P   UniProt 18039662, 15632203
S9 Phosphorylation PhosphoSitePlus   RLIMS-P 18039662
S23 Phosphorylation PhosphoSitePlus
S45 Phosphorylation PhosphoSitePlus   UniProt 18669648, 19690332
T49 Phosphorylation PhosphoSitePlus   UniProt 18669648, 19690332
T53 Phosphorylation PhosphoSitePlus
S56 Phosphorylation PhosphoSitePlus
S57 Phosphorylation PhosphoSitePlus
Y85 Phosphorylation PhosphoSitePlus
K216 Ubiquitination PhosphoSitePlus
K268 Ubiquitination PhosphoSitePlus
K304 Ubiquitination PhosphoSitePlus
K424 Ubiquitination PhosphoSitePlus
K435 Ubiquitination PhosphoSitePlus
K451 Ubiquitination PhosphoSitePlus
S496 Phosphorylation PhosphoSitePlus
S505 Phosphorylation PhosphoSitePlus
S507 Phosphorylation PhosphoSitePlus
T510 Phosphorylation PhosphoSitePlus
S544 Phosphorylation PhosphoSitePlus   UniProt 16964243, 19690332
S558 Phosphorylation PhosphoSitePlus   UniProt 21406692
S564 Phosphorylation PhosphoSitePlus   UniProt 21406692
T572 Phosphorylation PhosphoSitePlus
S574 Phosphorylation PhosphoSitePlus
S580 Phosphorylation PhosphoSitePlus
S586 Phosphorylation PhosphoSitePlus
T587 Phosphorylation PhosphoSitePlus
S588 Phosphorylation PhosphoSitePlus
S589 Phosphorylation PhosphoSitePlus
T590 Phosphorylation PhosphoSitePlus
T593 Phosphorylation PhosphoSitePlus
S599 Phosphorylation PhosphoSitePlus
S600 Phosphorylation PhosphoSitePlus
S605 Phosphorylation PhosphoSitePlus
S609 Phosphorylation PhosphoSitePlus
S612 Phosphorylation PhosphoSitePlus
S613 Phosphorylation PhosphoSitePlus
K620 Acetylation PhosphoSitePlus
S662 Phosphorylation PhosphoSitePlus
S665 Phosphorylation PhosphoSitePlus
T667 Phosphorylation PhosphoSitePlus
S668 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S9 Phosphorylation HPRD 18669648, 20058876
S45 Phosphorylation HPRD 18669648
T49 Phosphorylation HPRD 18669648
S544 Phosphorylation HPRD 16964243
S609 Phosphorylation HPRD 19413330, 18669648
S612 Phosphorylation HPRD 18669648
S613 Phosphorylation HPRD 19413330
Site PTM Type PTM Enzyme Score Source PMID
Y70 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S544 L544 Biomuta DOID:4159 / skin cancer [ icgc ] DOID:1909 / melanoma [ tcga ]
S564 L564 Biomuta DOID:10534 / stomach cancer [ tcga ]
T572 M572 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:5041 / esophageal cancer [ tcga ]
S609 P609 Biomuta DOID:263 / kidney cancer [ cosmic ]