iPTMnet Report for Q66K89 (E4F1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q66K89 / E4F1_HUMAN
Protein Name Transcription factor E4F1
Gene Name Name: E4F1
Synonyms:E4F;
Organism Homo sapiens (Human)

PRO ID PR:Q66K89
DAG View
PRO Name transcription factor E4F1 (human)
Definition A transcription factor E4F1 that is encoded in the genome of human.
Short Label hE4F1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q66K89 (E4F1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S50 Phosphorylation PhosphoSitePlus   UniProt 19690332, 20068231
S165 Phosphorylation PhosphoSitePlus
K188 Ubiquitination PhosphoSitePlus
K202 Sumoylation PhosphoSitePlus
K223 Sumoylation PhosphoSitePlus
C225 Methylation IEDB 31844290
T243 Phosphorylation PhosphoSitePlus
S251 Phosphorylation PhosphoSitePlus
S260 Phosphorylation PhosphoSitePlus
K268 Ubiquitination PhosphoSitePlus
S269 Phosphorylation PhosphoSitePlus
K289 Sumoylation PhosphoSitePlus
K289 Ubiquitination PhosphoSitePlus
T317 Phosphorylation PhosphoSitePlus
T325 Phosphorylation PhosphoSitePlus
S356 Phosphorylation Q13535 (ATR) neXtProt 10608806
T458 Phosphorylation PhosphoSitePlus
C468 Methylation IEDB 31844290
K501 Ubiquitination PhosphoSitePlus
K545 Sumoylation PhosphoSitePlus
K545 Ubiquitination PhosphoSitePlus
K559 Sumoylation PhosphoSitePlus
T570 Phosphorylation PhosphoSitePlus
K573 Ubiquitination PhosphoSitePlus
T589 Phosphorylation PhosphoSitePlus
S613 Phosphorylation PhosphoSitePlus
S772 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S165 N165 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
K188 N188 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T243 M243 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S251 C251 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S260 L260 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K268 R268 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S269 P269 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
T317 I317 Biomuta DOID:4159 / skin cancer [ cosmic ]
K573 R573 Biomuta DOID:4606 / bile duct cancer [ cosmic ]