iPTMnet Report for Q659A1 (ICE2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q659A1 / ICE2_HUMAN
Protein Name Little elongation complex subunit 2
Gene Name Name: ICE2
Synonyms:BRCC1,NARG2;ORFNames:UNQ3101/PRO10100;
Organism Homo sapiens (Human)

PRO ID PR:Q659A1
DAG View
PRO Name little elongation complex subunit 2 (human)
Definition A little elongation complex subunit 2 that is encoded in the genome of human.
Short Label hICE2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q659A1 (ICE2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S17 Phosphorylation PhosphoSitePlus   UniProt 23186163
K75 Acetylation PhosphoSitePlus
Y108 Phosphorylation PhosphoSitePlus
Y115 Phosphorylation PhosphoSitePlus
K117 Ubiquitination PhosphoSitePlus
K123 Ubiquitination PhosphoSitePlus
K129 Ubiquitination PhosphoSitePlus
Y132 Phosphorylation PhosphoSitePlus
Y135 Phosphorylation PhosphoSitePlus
K139 Acetylation PhosphoSitePlus
K140 Acetylation PhosphoSitePlus
K140 Ubiquitination PhosphoSitePlus
K151 Acetylation PhosphoSitePlus
K159 Ubiquitination PhosphoSitePlus
K177 Ubiquitination PhosphoSitePlus
T248 Phosphorylation PhosphoSitePlus
K271 Ubiquitination PhosphoSitePlus
S274 Phosphorylation PhosphoSitePlus
S284 Phosphorylation HPRD 20068231
S326 Phosphorylation PhosphoSitePlus   UniProt 23186163
K348 Ubiquitination PhosphoSitePlus
S388 Phosphorylation PhosphoSitePlus
S414 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S416 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S418 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S423 Phosphorylation PhosphoSitePlus
T424 Phosphorylation PhosphoSitePlus
S455 Phosphorylation PhosphoSitePlus
S457 Phosphorylation PhosphoSitePlus
T472 Phosphorylation PhosphoSitePlus
S519 Phosphorylation PhosphoSitePlus
S551 Phosphorylation PhosphoSitePlus
T592 Phosphorylation PhosphoSitePlus
S601 Phosphorylation PhosphoSitePlus
S605 Phosphorylation PhosphoSitePlus
S624 Phosphorylation PhosphoSitePlus
S695 Phosphorylation PhosphoSitePlus
S699 Phosphorylation PhosphoSitePlus
S932 Phosphorylation PhosphoSitePlus
T935 Phosphorylation PhosphoSitePlus
K940 Ubiquitination PhosphoSitePlus
T944 Phosphorylation PhosphoSitePlus
T948 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S414 Phosphorylation HPRD 18669648
S416 Phosphorylation HPRD 19413330, 18669648, 20068231
S418 Phosphorylation HPRD 18669648, 20068231
S421 Phosphorylation HPRD 20068231
T429 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S17 F17 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S17 Y17 Biomuta DOID:4159 / skin cancer [ cosmic ]
K117 E117 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K117 N117 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
K139 R139 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S274 F274 Biomuta DOID:4159 / skin cancer [ cosmic ]
S284 R284 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S388 T388 Biomuta DOID:3571 / liver cancer [ cosmic ]
T429 I429 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
T472 I472 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S519 Y519 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S932 L932 Biomuta [ cosmic ]