Protein Information

Cytoscape View


UniProt AC / UniProt ID Q63HR2 / TNS2_HUMAN
Protein Name Tensin-2
Gene Name Name: TNS2
Synonyms:KIAA1075,TENC1;
Organism Homo sapiens (Human)

PRO ID PR:Q63HR2
DAG View
PRO Name tensin-2 (human)
Definition A tensin-2 that is encoded in the genome of human.
Short Label hTNS2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q63HR2 (TNS2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S19 Phosphorylation PhosphoSitePlus
S20 Phosphorylation PhosphoSitePlus
S24 Phosphorylation PhosphoSitePlus
S33 Phosphorylation PhosphoSitePlus
R35 Methylation PhosphoSitePlus
T56 Phosphorylation PhosphoSitePlus
T91 Phosphorylation PhosphoSitePlus   UniProt 24275569
S102 Phosphorylation PhosphoSitePlus
T103 Phosphorylation PhosphoSitePlus
S118 Phosphorylation PhosphoSitePlus
S120 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
T186 Phosphorylation PhosphoSitePlus
Y245 Phosphorylation PhosphoSitePlus
Y248 Phosphorylation PhosphoSitePlus
S249 Phosphorylation PhosphoSitePlus
S252 Phosphorylation PhosphoSitePlus
N445 N-Glycosylation GlyGen 29671580
S455 Phosphorylation PhosphoSitePlus   UniProt 24275569
Y456 Phosphorylation PhosphoSitePlus   UniProt 24275569
S466 Phosphorylation PhosphoSitePlus   UniProt 24275569
S470 Phosphorylation PhosphoSitePlus
T472 Phosphorylation PhosphoSitePlus
T474 Phosphorylation PhosphoSitePlus   UniProt 24275569
S481 Phosphorylation PhosphoSitePlus
Y483 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 18083107, 30419905
T493 Phosphorylation PhosphoSitePlus
S498 Phosphorylation PhosphoSitePlus
S552 Phosphorylation PhosphoSitePlus
R555 Methylation PhosphoSitePlus
T571 Phosphorylation PhosphoSitePlus
T615 Phosphorylation PhosphoSitePlus
Y623 Phosphorylation PhosphoSitePlus
S629 Phosphorylation PhosphoSitePlus
Y633 Phosphorylation PhosphoSitePlus
S637 Phosphorylation PhosphoSitePlus
S646 Phosphorylation PhosphoSitePlus
S648 Phosphorylation PhosphoSitePlus
Y652 Phosphorylation PhosphoSitePlus
Y673 Phosphorylation PhosphoSitePlus
Y705 Phosphorylation PhosphoSitePlus
S769 Phosphorylation PhosphoSitePlus
Y770 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
S811 Phosphorylation PhosphoSitePlus
R816 Methylation PhosphoSitePlus
Y818 Phosphorylation PhosphoSitePlus
S820 Phosphorylation PhosphoSitePlus   UniProt 24275569
S825 Phosphorylation PhosphoSitePlus   UniProt 24275569
S830 Phosphorylation PhosphoSitePlus   UniProt 24275569
S832 Phosphorylation PhosphoSitePlus   UniProt 24275569
S835 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18220336
Y838 Phosphorylation PhosphoSitePlus
S845 Phosphorylation PhosphoSitePlus   UniProt 24275569
S893 Phosphorylation PhosphoSitePlus
S906 Phosphorylation PhosphoSitePlus
S909 Phosphorylation PhosphoSitePlus
T910 Phosphorylation PhosphoSitePlus
T914 Phosphorylation PhosphoSitePlus
S915 Phosphorylation PhosphoSitePlus
S916 Phosphorylation PhosphoSitePlus
T929 Phosphorylation PhosphoSitePlus
S931 Phosphorylation PhosphoSitePlus   UniProt 24275569
S941 Phosphorylation PhosphoSitePlus   UniProt 24275569
S950 O-Glycosylation GlyGen 28657654
S962 Phosphorylation PhosphoSitePlus
S964 Phosphorylation PhosphoSitePlus
S972 Phosphorylation PhosphoSitePlus   UniProt 24275569
S975 Phosphorylation PhosphoSitePlus
T977 Phosphorylation PhosphoSitePlus   UniProt 24275569
S991 Phosphorylation PhosphoSitePlus   UniProt 24275569
S996 Phosphorylation PhosphoSitePlus
S1000 Phosphorylation PhosphoSitePlus
S1003 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 24275569, 18220336
T1008 O-Glycosylation GlyGen 28657654
T1008 Phosphorylation PhosphoSitePlus
S1096 Phosphorylation PhosphoSitePlus
T1118 Phosphorylation PhosphoSitePlus
S1126 Phosphorylation PhosphoSitePlus
K1131 Ubiquitination PhosphoSitePlus
K1138 Ubiquitination PhosphoSitePlus
K1157 Ubiquitination PhosphoSitePlus
T1182 Phosphorylation PhosphoSitePlus   UniProt 24275569
S1218 Phosphorylation PhosphoSitePlus
Y1221 Phosphorylation PhosphoSitePlus
S1247 Phosphorylation PhosphoSitePlus   UniProt 24275569
S1342 Phosphorylation PhosphoSitePlus
T1344 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S19 Phosphorylation HPRD 20166139
S20 Phosphorylation HPRD 20166139
S24 Phosphorylation HPRD 20166139
S120 Phosphorylation HPRD 20166139
S455 Phosphorylation HPRD 17081983
S832 Phosphorylation HPRD 20166139
Site PTM Type PTM Enzyme Score Source PMID
S28 Phosphorylation PhosphoSitePlus
S130 Phosphorylation HPRD 20166139
S465 Phosphorylation HPRD 17081983
S842 Phosphorylation HPRD 20166139
Site PTM Type PTM Enzyme Score Source PMID
S331 Phosphorylation HPRD 17081983
S708 Phosphorylation HPRD 20166139


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P04626 (ERBB2) Y1139 Q63HR2 (TNS2) unknown eFIP 16273093
Phosphorylation P21860 (ERBB3) Y1197 Q63HR2 (TNS2) unknown eFIP 16273093


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S24 I24 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
T91 K91 Biomuta DOID:11934 / head and neck cancer [ tcga ]
S252 F252 Biomuta DOID:11934 / head and neck cancer [ tcga ]
T474 A474 Biomuta DOID:363 / uterine cancer [ tcga ]
S481 N481 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S646 L646 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S820 R820 Biomuta DOID:363 / uterine cancer [ icgc, tcga ]
Y838 N838 Biomuta DOID:1324 / lung cancer [ tcga ]
K1131 T1131 Biomuta DOID:1909 / melanoma [ cosmic ]
K1157 N1157 Biomuta DOID:363 / uterine cancer [ tcga ]