Protein Information

Cytoscape View


UniProt AC / UniProt ID Q63HN8 / RN213_HUMAN
Protein Name E3 ubiquitin-protein ligase RNF213
Gene Name Name: RNF213
Synonyms:ALO17;
Organism Homo sapiens (Human)

PRO ID PR:Q63HN8
DAG View
PRO Name E3 ubiquitin-protein ligase RNF213 (human)
Definition An E3 ubiquitin-protein ligase RNF213 that is encoded in the genome of human.
Short Label hRNF213
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q63HN8 (RNF213) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S43 Phosphorylation PhosphoSitePlus
S45 Phosphorylation PhosphoSitePlus
S67 Phosphorylation PhosphoSitePlus
S69 Phosphorylation PhosphoSitePlus
S82 Phosphorylation PhosphoSitePlus
S88 Phosphorylation PhosphoSitePlus
S193 Phosphorylation PhosphoSitePlus
S208 Phosphorylation PhosphoSitePlus   UniProt 24275569
S217 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231, 24275569
S232 Phosphorylation PhosphoSitePlus
T234 Phosphorylation PhosphoSitePlus
S246 Phosphorylation PhosphoSitePlus
T302 Phosphorylation PhosphoSitePlus
T303 Phosphorylation PhosphoSitePlus
K307 Methylation PhosphoSitePlus
T308 Phosphorylation PhosphoSitePlus
K412 Ubiquitination PhosphoSitePlus
K446 Ubiquitination PhosphoSitePlus
K472 Ubiquitination PhosphoSitePlus
K502 Ubiquitination PhosphoSitePlus
K509 Ubiquitination PhosphoSitePlus
K520 Ubiquitination PhosphoSitePlus
K595 Ubiquitination PhosphoSitePlus
K596 Ubiquitination PhosphoSitePlus
K605 Ubiquitination PhosphoSitePlus
K747 Ubiquitination PhosphoSitePlus
Y844 Phosphorylation PhosphoSitePlus
K860 Ubiquitination PhosphoSitePlus
T894 Phosphorylation PhosphoSitePlus
T906 Phosphorylation PhosphoSitePlus
K911 Ubiquitination PhosphoSitePlus
T919 Phosphorylation PhosphoSitePlus
K967 Ubiquitination PhosphoSitePlus
K985 Ubiquitination PhosphoSitePlus
K993 Ubiquitination PhosphoSitePlus
K1058 Ubiquitination PhosphoSitePlus
T1066 Phosphorylation PhosphoSitePlus
K1069 Ubiquitination PhosphoSitePlus
K1079 Ubiquitination PhosphoSitePlus
K1113 Ubiquitination PhosphoSitePlus
S1128 Phosphorylation PhosphoSitePlus
K1151 Sumoylation PhosphoSitePlus
K1151 Ubiquitination PhosphoSitePlus
K1162 Ubiquitination PhosphoSitePlus
K1223 Acetylation PhosphoSitePlus
K1223 Ubiquitination PhosphoSitePlus
K1248 Ubiquitination PhosphoSitePlus
S1258 Phosphorylation PhosphoSitePlus   UniProt 19369195, 21406692, 23186163, ...18691976, 18318008, 18669648, 24275569, 19690332, 20068231
K1285 Ubiquitination PhosphoSitePlus
K1288 Ubiquitination PhosphoSitePlus
K1313 Ubiquitination PhosphoSitePlus
K1337 Ubiquitination PhosphoSitePlus
K1344 Ubiquitination PhosphoSitePlus
K1357 Ubiquitination PhosphoSitePlus
K1404 Ubiquitination PhosphoSitePlus
K1405 Ubiquitination PhosphoSitePlus
K1416 Ubiquitination PhosphoSitePlus
K1425 Ubiquitination PhosphoSitePlus
K1490 Ubiquitination PhosphoSitePlus
K1497 Ubiquitination PhosphoSitePlus
K1501 Ubiquitination PhosphoSitePlus
K1508 Ubiquitination PhosphoSitePlus
K1520 Ubiquitination PhosphoSitePlus
K1552 Ubiquitination PhosphoSitePlus
K1556 Ubiquitination PhosphoSitePlus
K1586 Ubiquitination PhosphoSitePlus
K1591 Ubiquitination PhosphoSitePlus
K1718 Ubiquitination PhosphoSitePlus
K1733 Ubiquitination PhosphoSitePlus
K1971 Ubiquitination PhosphoSitePlus
T1973 Phosphorylation PhosphoSitePlus
K1998 Ubiquitination PhosphoSitePlus
Y2001 Phosphorylation PhosphoSitePlus
K2003 Ubiquitination PhosphoSitePlus
K2010 Acetylation PhosphoSitePlus
K2010 Ubiquitination PhosphoSitePlus
K2016 Ubiquitination PhosphoSitePlus
K2021 Ubiquitination PhosphoSitePlus
T2104 Phosphorylation PhosphoSitePlus
S2105 Phosphorylation PhosphoSitePlus
S2108 Phosphorylation PhosphoSitePlus
S2112 Phosphorylation PhosphoSitePlus
K2136 Ubiquitination PhosphoSitePlus
S2266 Phosphorylation PhosphoSitePlus
S2273 Phosphorylation PhosphoSitePlus   UniProt 23186163
T2280 Phosphorylation PhosphoSitePlus
K2367 Ubiquitination PhosphoSitePlus
K2391 Ubiquitination PhosphoSitePlus
K2426 Ubiquitination PhosphoSitePlus
K2431 Ubiquitination PhosphoSitePlus
R2438 Methylation PhosphoSitePlus
T2441 Phosphorylation PhosphoSitePlus
K2447 Ubiquitination PhosphoSitePlus
K2450 Ubiquitination PhosphoSitePlus
Y2461 Phosphorylation PhosphoSitePlus
K2529 Ubiquitination PhosphoSitePlus
K2628 Ubiquitination PhosphoSitePlus
S2684 Phosphorylation PhosphoSitePlus
Y2693 Phosphorylation PhosphoSitePlus
S2696 Phosphorylation PhosphoSitePlus
K2713 Ubiquitination PhosphoSitePlus
K2740 Ubiquitination PhosphoSitePlus
K2744 Ubiquitination PhosphoSitePlus
K2770 Ubiquitination PhosphoSitePlus
K2775 Ubiquitination PhosphoSitePlus
S2776 Phosphorylation PhosphoSitePlus
K2779 Ubiquitination PhosphoSitePlus
S2798 Phosphorylation PhosphoSitePlus
K2800 Ubiquitination PhosphoSitePlus
K2832 Ubiquitination PhosphoSitePlus
K2858 Ubiquitination PhosphoSitePlus
K2877 Acetylation PhosphoSitePlus
K2877 Ubiquitination PhosphoSitePlus
K2878 Ubiquitination PhosphoSitePlus
K2893 Ubiquitination PhosphoSitePlus
K2915 Ubiquitination PhosphoSitePlus
Y2931 Phosphorylation PhosphoSitePlus
K2937 Ubiquitination PhosphoSitePlus
K2944 Ubiquitination PhosphoSitePlus
K2948 Ubiquitination PhosphoSitePlus
K2968 Ubiquitination PhosphoSitePlus
K2973 Ubiquitination PhosphoSitePlus
K2990 Ubiquitination PhosphoSitePlus
K3007 Ubiquitination PhosphoSitePlus
K3019 Ubiquitination PhosphoSitePlus
K3028 Ubiquitination PhosphoSitePlus
S3039 Phosphorylation PhosphoSitePlus
K3091 Ubiquitination PhosphoSitePlus
Y3158 Phosphorylation PhosphoSitePlus
K3159 Ubiquitination PhosphoSitePlus
K3171 Ubiquitination PhosphoSitePlus
K3182 Ubiquitination PhosphoSitePlus
K3202 Ubiquitination PhosphoSitePlus
K3208 Acetylation PhosphoSitePlus
K3208 Ubiquitination PhosphoSitePlus
K3249 Ubiquitination PhosphoSitePlus
K3255 Ubiquitination PhosphoSitePlus
R3311 Methylation PhosphoSitePlus
K3371 Ubiquitination PhosphoSitePlus
K3395 Ubiquitination PhosphoSitePlus
Y3396 Phosphorylation PhosphoSitePlus
T3449 Phosphorylation PhosphoSitePlus
K3517 Ubiquitination PhosphoSitePlus
S3538 Phosphorylation PhosphoSitePlus
R3559 Methylation PhosphoSitePlus
R3580 Methylation PhosphoSitePlus
K3592 Ubiquitination PhosphoSitePlus
K3738 Ubiquitination PhosphoSitePlus
K3799 Ubiquitination PhosphoSitePlus
K3876 Ubiquitination PhosphoSitePlus
K3957 Ubiquitination PhosphoSitePlus
K3966 Ubiquitination PhosphoSitePlus
K3982 Ubiquitination PhosphoSitePlus
K3987 Ubiquitination PhosphoSitePlus
K4005 Ubiquitination PhosphoSitePlus
Y4034 Phosphorylation PhosphoSitePlus
K4115 Ubiquitination PhosphoSitePlus
S4116 Phosphorylation PhosphoSitePlus
K4126 Ubiquitination PhosphoSitePlus
S4132 Phosphorylation PhosphoSitePlus
Y4141 Phosphorylation PhosphoSitePlus
K4158 Ubiquitination PhosphoSitePlus
K4159 Ubiquitination PhosphoSitePlus
K4160 Ubiquitination PhosphoSitePlus
K4206 Ubiquitination PhosphoSitePlus
Y4225 Phosphorylation PhosphoSitePlus
K4254 Ubiquitination PhosphoSitePlus
K4256 Ubiquitination PhosphoSitePlus
K4264 Ubiquitination PhosphoSitePlus
K4297 Ubiquitination PhosphoSitePlus
K4308 Ubiquitination PhosphoSitePlus
K4312 Ubiquitination PhosphoSitePlus
K4335 Ubiquitination PhosphoSitePlus
K4343 Ubiquitination PhosphoSitePlus
K4349 Ubiquitination PhosphoSitePlus
K4354 Ubiquitination PhosphoSitePlus
K4402 Ubiquitination PhosphoSitePlus
K4408 Ubiquitination PhosphoSitePlus
K4495 Ubiquitination PhosphoSitePlus
K4538 Ubiquitination PhosphoSitePlus
K4547 Ubiquitination PhosphoSitePlus
T4586 Phosphorylation PhosphoSitePlus
K4622 Ubiquitination PhosphoSitePlus
K4671 Ubiquitination PhosphoSitePlus
K4679 Ubiquitination PhosphoSitePlus
K4694 Ubiquitination PhosphoSitePlus
K4707 Ubiquitination PhosphoSitePlus
K4716 Ubiquitination PhosphoSitePlus
Y4719 Phosphorylation PhosphoSitePlus
K4732 Ubiquitination PhosphoSitePlus
K4739 Ubiquitination PhosphoSitePlus
Y4751 Phosphorylation PhosphoSitePlus
K4759 Ubiquitination PhosphoSitePlus
K4774 Ubiquitination PhosphoSitePlus
K4782 Ubiquitination PhosphoSitePlus
K4796 Ubiquitination PhosphoSitePlus
K4815 Ubiquitination PhosphoSitePlus
Y4896 Phosphorylation PhosphoSitePlus
K4955 Ubiquitination PhosphoSitePlus
K4968 Methylation PhosphoSitePlus
K4968 Ubiquitination PhosphoSitePlus
K4974 Methylation PhosphoSitePlus
K4974 Ubiquitination PhosphoSitePlus
Y4981 Phosphorylation PhosphoSitePlus
K4995 Ubiquitination PhosphoSitePlus
K5095 Ubiquitination PhosphoSitePlus
S5102 Phosphorylation PhosphoSitePlus
S5103 Phosphorylation PhosphoSitePlus
K5106 Ubiquitination PhosphoSitePlus
K5142 Ubiquitination PhosphoSitePlus
K5201 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S217 Phosphorylation HPRD   PhosphoSitePlus 18077418, 20068231
T293 Phosphorylation PhosphoSitePlus
T302 Phosphorylation PhosphoSitePlus
T303 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K446 R446 Biomuta DOID:363 / uterine cancer [ tcga ]
K446 T446 Biomuta DOID:9256 / colorectal cancer [ tcga ]
K1079 N1079 Biomuta DOID:9256 / colorectal cancer [ icgc ] DOID:263 / kidney cancer [ cosmic ]
K1113 N1113 Biomuta DOID:9256 / colorectal cancer [ icgc ]
K1405 N1405 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K2016 E2016 Biomuta DOID:9256 / colorectal cancer [ tcga ]
S2108 L2108 Biomuta DOID:1612 / breast cancer [ tcga ]
S2112 * Biomuta DOID:1793 / pancreatic cancer [ tcga ]
S2273 I2273 Biomuta DOID:3571 / liver cancer [ icgc ]
K2426 E2426 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:11054 / urinary bladder cancer [ icgc, tcga ]
R2438 H2438 Biomuta DOID:1793 / pancreatic cancer [ tcga ]
K2447 N2447 Biomuta DOID:3571 / liver cancer [ icgc ]
K2713 T2713 Biomuta DOID:363 / uterine cancer [ tcga ]
K2744 N2744 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
K2800 N2800 Biomuta DOID:363 / uterine cancer [ tcga ]
K3171 N3171 Biomuta DOID:3571 / liver cancer [ icgc ]
K3249 Q3249 Biomuta DOID:363 / uterine cancer [ tcga ]
R3311 H3311 Biomuta DOID:3963 / thyroid carcinoma [ icgc ]
R3559 Q3559 Biomuta DOID:9256 / colorectal cancer [ tcga ]
Y4141 H4141 Biomuta DOID:363 / uterine cancer [ tcga ]
Y4225 * Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
Y4225 S4225 Biomuta DOID:1612 / breast cancer [ icgc ]
K4408 N4408 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:2531 / hematologic cancer [ tcga ]
K4671 E4671 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K4732 E4732 Biomuta DOID:1612 / breast cancer [ icgc ]
K4739 N4739 Biomuta DOID:5041 / esophageal cancer [ icgc ]
K4759 N4759 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
K4968 N4968 Biomuta DOID:3571 / liver cancer [ icgc ]
K5095 R5095 Biomuta DOID:1909 / melanoma [ cosmic ]