Protein Information

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UniProt AC / UniProt ID Q62120 / JAK2_MOUSE
Protein Name Tyrosine-protein kinase JAK2
Gene Name Name: Jak2
Organism Mus musculus (Mouse)

PRO ID PR:Q62120
DAG View
PRO Name tyrosine-protein kinase JAK2 (mouse)
Definition A tyrosine-protein kinase JAK2 that is encoded in the genome of mouse.
Short Label mJAK2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q62120 (Jak2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y119 Phosphorylation Q62120 (Jak2) PhosphoSitePlus   UniProt 17024180, 15530433
Y134 Phosphorylation PhosphoSitePlus
Y201 Phosphorylation Q62120 (Jak2) IntAct   PhosphoSitePlus 17027227
Y206 Phosphorylation Q62120 (Jak2) PhosphoSitePlus 17027227
Y221 Phosphorylation Q62120 (Jak2) phospho.ELM   PhosphoSitePlus   RLIMS-P 15143187, 26799659, 15530433, ...15143188
K244 Ubiquitination PhosphoSitePlus
Y317 Phosphorylation Q62120 (Jak2) PhosphoSitePlus 19364823
Y372 Phosphorylation PhosphoSitePlus   UniProt 21726629
Y373 Phosphorylation PhosphoSitePlus   UniProt 21726629
K415 Ubiquitination PhosphoSitePlus
Y423 Phosphorylation PhosphoSitePlus
Y435 Phosphorylation PhosphoSitePlus
K468 Ubiquitination PhosphoSitePlus
S523 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 19144319, 21183079, 16705160, ...16705159
T525 Phosphorylation PhosphoSitePlus
Y570 Phosphorylation Q62120 (Jak2) phospho.ELM   PhosphoSitePlus 15530433, 15143187, 16705159, ...15143188
K585 Acetylation PhosphoSitePlus
Y613 Phosphorylation PhosphoSitePlus
Y637 Phosphorylation Q62120 (Jak2) PhosphoSitePlus 15530433, 19364823
S668 Phosphorylation PhosphoSitePlus
Y813 Phosphorylation Q62120 (Jak2) IntAct   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 15121872, 16824542, 28912580, ...16914724, 17565041
Y868 Phosphorylation Q62120 (Jak2) PhosphoSitePlus   RLIMS-P   UniProt 28912580, 15530433, 20304997
S904 Phosphorylation PhosphoSitePlus
K912 Acetylation PhosphoSitePlus
Y913 Phosphorylation Q62120 (Jak2) PhosphoSitePlus 18682290
Y918 Phosphorylation Q62120 (Jak2) PhosphoSitePlus 15530433
Y931 Phosphorylation Q62120 (Jak2) PhosphoSitePlus 15530433
Y934 Phosphorylation Q62120 (Jak2) PhosphoSitePlus 15530433
Y940 Phosphorylation Q62120 (Jak2) PhosphoSitePlus 15530433
Y966 Phosphorylation Q62120 (Jak2) PhosphoSitePlus   RLIMS-P   UniProt 28912580, 15530433, 20304997
Y972 Phosphorylation Q62120 (Jak2) PhosphoSitePlus   RLIMS-P   UniProt 28912580, 15530433, 20304997
Y1007 Phosphorylation Q62120 (Jak2) IntAct   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 20068132, 28100634, 32943679, ...26788034, 15143187, 28912580, 15530433, 10064597, 32413585, 9473212, 11593427, 16705159, 27977755, 26949510, 17849321, 30070632, 15793561, 24251790, 15923602, 9111318, 17404288, 16705160, 20304997, 31943454
Y1008 Phosphorylation Q62120 (Jak2) phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 11593427, 20068132, 30070632, ...33413536, 20304997, 15530433, 27977755, 32943679, 15923602, 9111318, 26788034, 28912580, 16705160, 15793561, 26949510, 16705159, 32413585, 17849321


Q62120 (Jak2) as PTM Enzyme



Substrate Site Score Source PMID
P09793 (Ctla4) Y201 phospho.ELM 10842319
P35235 (Ptpn11) Y304 PhosphoSitePlus 8995399
P35235 (Ptpn11) Y327 PhosphoSitePlus 8995399
P42227 (Stat3) Y705 PhosphoSitePlus 11278353
P42230 (Stat5a) Y694 PhosphoSitePlus 12529425
P46414 (Cdkn1b) Y88 PhosphoSitePlus 21423214
Q62120 (Jak2) Y119 PhosphoSitePlus   UniProt 17024180, 15530433
Q62120 (Jak2) Y201 PhosphoSitePlus 17027227
Q62120 (Jak2) Y206 PhosphoSitePlus 17027227
Q62120 (Jak2) Y221 phospho.ELM   PhosphoSitePlus 15143187, 15530433, 15143188
Q62120 (Jak2) Y317 PhosphoSitePlus 19364823
Q62120 (Jak2) Y570 phospho.ELM   PhosphoSitePlus 15530433, 15143187, 16705159, ...15143188
Q62120 (Jak2) Y637 PhosphoSitePlus 15530433, 19364823
Q62120 (Jak2) Y813 phospho.ELM   PhosphoSitePlus 15121872
Q62120 (Jak2) Y868 PhosphoSitePlus   UniProt 15530433, 20304997
Q62120 (Jak2) Y913 PhosphoSitePlus 18682290
Q62120 (Jak2) Y918 PhosphoSitePlus 15530433
Q62120 (Jak2) Y931 PhosphoSitePlus 15530433
Q62120 (Jak2) Y934 PhosphoSitePlus 15530433
Q62120 (Jak2) Y940 PhosphoSitePlus 15530433
Q62120 (Jak2) Y966 PhosphoSitePlus   UniProt 15530433, 20304997
Q62120 (Jak2) Y972 PhosphoSitePlus   UniProt 15530433, 20304997
Q62120 (Jak2) Y1007 phospho.ELM   PhosphoSitePlus   UniProt 15143187, 9111318, 15530433, ...20304997, 9473212
Q62120 (Jak2) Y1008 phospho.ELM   PhosphoSitePlus   UniProt 9111318, 15530433, 20304997
Q99N57 (Raf1) Y340 Signor 8876196
Q99N57 (Raf1) Y341 Signor 8876196
Q9ESZ8 (Gtf2i) Y248 Signor 11313464


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q62120 (Jak2) Y1007 O35716 (Socs1) unknown eFIP 10064597
Phosphorylation Q62120 (Jak2) Y201 P35235 (Ptpn11) unknown eFIP 17027227
Phosphorylation Q62120 (Jak2) Y813 Q9Z200 (Sh2b2) unknown eFIP 16914724
Phosphorylation Q62120 (Jak2) Y813 Q91ZM2 (Sh2b1) unknown eFIP 15121872
Phosphorylation Q62120 (Jak2) Y813 Q62985 (Sh2b1) unknown eFIP 16914724
Phosphorylation Q62120 (Jak2) Y813 Q91ZM2 (Sh2b1) unknown eFIP 16824542