Protein Information

Cytoscape View


UniProt AC / UniProt ID Q61337 / BAD_MOUSE
Protein Name Bcl2-associated agonist of cell death
Gene Name Name: Bad
Synonyms:Bbc6;
Organism Mus musculus (Mouse)

PRO ID PR:Q61337
DAG View
PRO Name Bcl2-associated agonist of cell death (mouse)
Definition A Bcl2-associated agonist of cell death that is encoded in the genome of mouse.
Short Label mBAD
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q61337 (Bad) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S20 Phosphorylation PhosphoSitePlus
S26 Phosphorylation PhosphoSitePlus   RLIMS-P 23332762
Y76 Phosphorylation PhosphoSitePlus
T94 Phosphorylation P58750 (Pim3) PhosphoSitePlus 16403219
S96 Phosphorylation P58750 (Pim3) PhosphoSitePlus 16403219
S108 Phosphorylation PhosphoSitePlus
S111 Phosphorylation PhosphoSitePlus
S112 Phosphorylation P06803 (Pim1) , Q8C050 (Rps6ka5) , P05132 (Prkaca) , P31750 (Akt1) , P18653 (Rps6ka1) , Q91Y86 (Mapk8) , Q8C015 (Pak5) , P58750 (Pim3) , P18654 (Rps6ka3) phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 15849194, 12897128, 11723239, ...23054079, 17242355, 10949026, 16403219, 11278362, 10611223, 30107910, 22132131, 12954615, 12189144, 10679322, 30063064, 10230394, 23826368, 15123689, 16103085, 14585539, 9346240, 8929531, 15843895, 21216283, 11983683, 10880354, 15280015, 19915011, 9381178
Y113 Phosphorylation PhosphoSitePlus
T117 Phosphorylation phospho.ELM   PhosphoSitePlus 15234118
S128 Phosphorylation P11440 (Cdk1) , Q91Y86 (Mapk8) phospho.ELM   PhosphoSitePlus   RLIMS-P 12189144, 15907327
S134 Phosphorylation PhosphoSitePlus
S136 Phosphorylation P58750 (Pim3) , P05132 (Prkaca) , P31750 (Akt1) , P06803 (Pim1) phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 10949026, 10611223, 12087097, ...21183079, 23826368, 15123689, 11342610, 14585539, 11493700, 23054079, 15843895, 16403219, 15280015, 12189144, 16935431, 9346240, 9381178, 10679322
S155 Phosphorylation P58750 (Pim3) , P0C605 (Prkg1) , P31750 (Akt1) , P18653 (Rps6ka1) , P05132 (Prkaca) phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 11717309, 10880354, 21183079, ...15123689, 20043968, 14585539, 23054079, 15843895, 10949026, 16403219, 10837473, 16935431, 10837486
S161 Phosphorylation PhosphoSitePlus
S170 Phosphorylation P58750 (Pim3) phospho.ELM   PhosphoSitePlus   UniProt 11717309, 16403219, 21183079
T173 Phosphorylation P58750 (Pim3) PhosphoSitePlus 16403219
T201 Phosphorylation Q91Y86 (Mapk8) phospho.ELM   PhosphoSitePlus   RLIMS-P 21095239, 14967141
Site PTM Type PTM Enzyme Score Source PMID
S112 Phosphorylation PR:000029188 (cAMP-dependent protein kinase catalytic subunit) , PR:000029189 (AKT kinase) , PR:000014284 (RPS6KA3) PRO 8929531, 10880354, 10949026, ...9346240
S128 Phosphorylation PR:000029190 (cyclin B:Cdk1 complex) PRO 12049737
S136 Phosphorylation PR:000029188 (cAMP-dependent protein kinase catalytic subunit) , PR:000029189 (AKT kinase) , PR:000014284 (RPS6KA3) PRO 10949026, 8929531, 12049737, ...9346240, 10880354
S155 Phosphorylation PR:000014284 (RPS6KA3) , PR:000029188 (cAMP-dependent protein kinase catalytic subunit) , PR:000029189 (AKT kinase) PRO 10949026, 10880354
T201 Phosphorylation PR:000002206 (MAPK8) PRO 14967141


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000026133 (mBAD/iso:1/Phos:2) pS112,pS136,pS155 PR:000014284 (RPS6KA3) PRO 10880354, 10949026
PR:000026133 (mBAD/iso:1/Phos:2) pS112,pS136,pS155 PR:000029188 (cAMP-dependent protein kinase catalytic subunit) PRO 10880354, 10949026
PR:000026133 (mBAD/iso:1/Phos:2) pS112,pS136,pS155 PR:000029189 (AKT kinase) PRO 10880354, 10949026
PR:000026135 (mBAD/iso:1/Phos:4) pT201 PR:000002206 (MAPK8) PRO 14967141
PR:000026136 (mBAD/iso:1/Phos:5) pS136 PRO 12049737
PR:000026137 (mBAD/iso:1/Phos:6) pS136 PRO 12049737
PR:000026137 (mBAD/iso:1/Phos:6) pS128 PR:000029190 (cyclin B:Cdk1 complex) PRO 12049737
PR:000026138 (mBAD/iso:1/Phos:7) pS155 PRO 10880354
PR:000026138 (mBAD/iso:1/Phos:7) pS112 PR:000014284 (RPS6KA3) PRO 10880354
PR:000026139 (mBAD/iso:1/Phos:8) pS155 PR:000029188 (cAMP-dependent protein kinase catalytic subunit) PRO 10880354
PR:000026167 (mBAD/iso:1/Phos:1) pS112,pS136 PR:000029188 (cAMP-dependent protein kinase catalytic subunit) PRO 10949026, 8929531, 9346240
PR:000026167 (mBAD/iso:1/Phos:1) pS112,pS136 PR:000029189 (AKT kinase) PRO 10949026, 8929531, 9346240


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q61337 (Bad) S112 P68254 (Ywhaq) increased_association eFIP 10611223
Phosphorylation Q61337 (Bad) T201 Q64373 (Bcl2l1) inhibited_association eFIP 21095239
Phosphorylation Q61337 (Bad) S112 P10417 (Bcl2) decreased_association eFIP 10611223


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000026133 (mBAD/iso:1/Phos:2) Interaction PR:000003237 (14-3-3 protein) PRO 16403219
PR:000026133 (mBAD/iso:1/Phos:2) decreased Interaction PR:Q64373-1 (mBCL2L1/iso:Bcl-X(L)) PRO 16403219
PR:000026133 (mBAD/iso:1/Phos:2) NOT Interaction PR:Q07817-1 (hBCL2L1/iso:1) PRO 10949026
PR:000026133 (mBAD/iso:1/Phos:2) Interaction PR:P63101-1 (mYWHAZ/iso:1) PRO 10949026
PR:000026135 (mBAD/iso:1/Phos:4) decreased Interaction PR:Q64373-1 (mBCL2L1/iso:Bcl-X(L)) PRO 14967141
PR:000026136 (mBAD/iso:1/Phos:5) Interaction PR:P63101 (mYWHAZ) PRO 12049737
PR:000026139 (mBAD/iso:1/Phos:8) Interaction PR:P61982 (mYWHAG) PRO 10880354
PR:000026167 (mBAD/iso:1/Phos:1) decreased Interaction PR:P63101 (mYWHAZ) PRO 12049737
PR:000026167 (mBAD/iso:1/Phos:1) Interaction PR:Q07817-1 (hBCL2L1/iso:1) PRO 10949026
PR:000026167 (mBAD/iso:1/Phos:1) Interaction PR:Q9CQV8 (mYWHAB) PRO 10490655
PR:000026167 (mBAD/iso:1/Phos:1) Interaction PR:P62258-1 (hYWHAE/iso:1) PRO 10490655
PR:000044747 (mBAD/iso:1/UnMod) Interaction PR:P15056 (hBRAF) PRO 17011751
PR:000044747 (mBAD/iso:1/UnMod) Interaction PR:P06803-2 (mPIM1/iso:2) PRO 15280015
PR:000044747 (mBAD/iso:1/UnMod) Interaction PR:Q04759 (hPRKCQ) PRO 17011751
PR:000044747 (mBAD/iso:1/UnMod) Interaction PR:P04049 (hRAF1) PRO 17011751
PR:P62258-1 (hYWHAE/iso:1) Interaction PR:000026133 (mBAD/iso:1/Phos:2) PRO 10949026
PR:P62258-1 (hYWHAE/iso:1) Interaction PR:000026167 (mBAD/iso:1/Phos:1) PRO 10949026
PR:Q07817-1 (hBCL2L1/iso:1) Interaction PR:Q61337 (mBAD) PRO 11583631
PR:Q07817-1 (hBCL2L1/iso:1) NOT Interaction PR:000026133 (mBAD/iso:1/Phos:2) PRO 10949026
PR:Q07817-1 (hBCL2L1/iso:1) decreased Interaction PR:000026167 (mBAD/iso:1/Phos:1) PRO 10949026