iPTMnet Report for Q5XPI4 (RNF123)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q5XPI4 / RN123_HUMAN
Protein Name E3 ubiquitin-protein ligase RNF123
Gene Name Name: RNF123
Synonyms:KPC1;ORFNames:FP1477;
Organism Homo sapiens (Human)

PRO ID PR:Q5XPI4
DAG View
PRO Name E3 ubiquitin-protein ligase RNF123 (human)
Definition An E3 ubiquitin-protein ligase RNF123 that is encoded in the genome of human.
Short Label hRNF123
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q5XPI4 (RNF123) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Ubiquitination PRO
A2 Acetylation UniProt 22814378
K4 Acetylation PhosphoSitePlus
K4 Ubiquitination PhosphoSitePlus
S9 Phosphorylation PhosphoSitePlus
S11 Phosphorylation PhosphoSitePlus
K13 Acetylation PhosphoSitePlus
S14 Phosphorylation PhosphoSitePlus
Y15 Phosphorylation PhosphoSitePlus
T18 Phosphorylation PhosphoSitePlus
S19 Phosphorylation PhosphoSitePlus
K33 Ubiquitination PhosphoSitePlus
K57 Ubiquitination PhosphoSitePlus
S126 Phosphorylation PhosphoSitePlus
T127 Phosphorylation PhosphoSitePlus
T128 Phosphorylation PhosphoSitePlus
Y131 Phosphorylation PhosphoSitePlus
K180 Ubiquitination PhosphoSitePlus
S240 Phosphorylation IEDB 32387766
R306 Methylation PhosphoSitePlus
K467 Ubiquitination PhosphoSitePlus
T470 O-Glycosylation GlyGen 30379171, 36240223, 30620550
K473 Ubiquitination PhosphoSitePlus
K515 Ubiquitination PhosphoSitePlus
K530 Ubiquitination PhosphoSitePlus
K533 Ubiquitination PhosphoSitePlus
S610 O-Glycosylation GlyGen 30379171, 36240223, 30620550
S610 Phosphorylation PhosphoSitePlus
K614 Ubiquitination PhosphoSitePlus
K617 Ubiquitination PhosphoSitePlus
S674 Phosphorylation PhosphoSitePlus
S675 Phosphorylation PhosphoSitePlus
T677 Phosphorylation PhosphoSitePlus
S686 Phosphorylation PhosphoSitePlus
T694 Phosphorylation PhosphoSitePlus
S700 Phosphorylation PhosphoSitePlus
S702 Phosphorylation PhosphoSitePlus
K704 Ubiquitination PhosphoSitePlus
S711 Phosphorylation PhosphoSitePlus
K789 Ubiquitination PhosphoSitePlus
K798 Ubiquitination PhosphoSitePlus
K806 Ubiquitination PhosphoSitePlus
K809 Ubiquitination PhosphoSitePlus
K814 Acetylation PhosphoSitePlus
K814 Ubiquitination PhosphoSitePlus
K906 Ubiquitination PhosphoSitePlus
Y983 Phosphorylation PhosphoSitePlus
K991 Methylation PhosphoSitePlus
T992 Phosphorylation PhosphoSitePlus
K993 Methylation PhosphoSitePlus
T1123 O-Glycosylation GlyGen 30379171, 36240223, 30620550
R1131 Methylation PhosphoSitePlus
K1286 Ubiquitination PhosphoSitePlus
S1312 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S675 Phosphorylation HPRD 19651622, 19664994


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049049 (hRNF123/UbiqLys+) ub PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S11 F11 Biomuta DOID:4159 / skin cancer [ cosmic ]
K13 T13 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T127 I127 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
T128 A128 Biomuta DOID:1319 / brain cancer [ cosmic ]
S240 C240 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S240 A240 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
R306 Q306 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic ]
R306 W306 Biomuta DOID:4362 / cervical cancer [ icgc ]
S610 L610 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K614 N614 Biomuta DOID:4159 / skin cancer [ cosmic ]
K798 N798 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
R1131 C1131 Biomuta DOID:1793 / pancreatic cancer [ icgc ]
S1312 * Biomuta DOID:4362 / cervical cancer [ cosmic ]