Protein Information

Cytoscape View


UniProt AC / UniProt ID Q5W0B1 / OBI1_HUMAN
Protein Name ORC ubiquitin ligase 1
Gene Name Name: OBI1
Synonyms:C13orf7,RNF219;
Organism Homo sapiens (Human)

PRO ID PR:Q5W0B1
DAG View
PRO Name RING finger protein 219 (human)
Definition A RING finger protein 219 that is encoded in the genome of human.
Short Label hRNF219
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q5W0B1 (OBI1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T60 Phosphorylation PhosphoSitePlus
K66 Ubiquitination PhosphoSitePlus
T72 Phosphorylation PhosphoSitePlus
S75 Phosphorylation PhosphoSitePlus
K97 Ubiquitination PhosphoSitePlus
Y99 Phosphorylation PhosphoSitePlus
K108 Ubiquitination PhosphoSitePlus
S119 Phosphorylation HPRD   PhosphoSitePlus 19651622, 20068231
K125 Acetylation PhosphoSitePlus
K125 Ubiquitination PhosphoSitePlus
K142 Ubiquitination PhosphoSitePlus
K151 Ubiquitination PhosphoSitePlus
T166 Phosphorylation PhosphoSitePlus
Y171 Phosphorylation PhosphoSitePlus
K173 Ubiquitination PhosphoSitePlus
S210 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19651622, 23186163, 20068231
K213 Ubiquitination PhosphoSitePlus
K225 Acetylation PhosphoSitePlus
K225 Ubiquitination PhosphoSitePlus
S243 Phosphorylation HPRD   PhosphoSitePlus 20068231
K245 Ubiquitination PhosphoSitePlus
Y246 Phosphorylation PhosphoSitePlus
S252 Phosphorylation PhosphoSitePlus
K258 Ubiquitination PhosphoSitePlus
S260 Phosphorylation PhosphoSitePlus
S261 Phosphorylation PhosphoSitePlus
K264 Ubiquitination PhosphoSitePlus
S276 Phosphorylation PhosphoSitePlus
K280 Ubiquitination PhosphoSitePlus
K283 Ubiquitination PhosphoSitePlus
K292 Ubiquitination PhosphoSitePlus
S297 Phosphorylation PhosphoSitePlus
K300 Ubiquitination PhosphoSitePlus
S304 Phosphorylation PhosphoSitePlus
K314 Ubiquitination PhosphoSitePlus
S330 Phosphorylation PhosphoSitePlus
T331 Phosphorylation PhosphoSitePlus
S332 Phosphorylation PhosphoSitePlus
K333 Sumoylation PhosphoSitePlus
K333 Ubiquitination PhosphoSitePlus
K340 Ubiquitination PhosphoSitePlus
Y345 Phosphorylation PhosphoSitePlus
K371 Ubiquitination PhosphoSitePlus
T391 Phosphorylation PhosphoSitePlus
S416 Phosphorylation HPRD   PhosphoSitePlus 16964243
K417 Acetylation PhosphoSitePlus
K417 Ubiquitination PhosphoSitePlus
K425 Sumoylation PhosphoSitePlus
K425 Ubiquitination PhosphoSitePlus
S438 Phosphorylation HPRD   PhosphoSitePlus 19413330
K440 Ubiquitination PhosphoSitePlus
S442 Phosphorylation PhosphoSitePlus
S443 Phosphorylation PhosphoSitePlus
K454 Ubiquitination PhosphoSitePlus
K455 Sumoylation PhosphoSitePlus
K455 Ubiquitination PhosphoSitePlus
S460 Phosphorylation PhosphoSitePlus
S461 Phosphorylation PhosphoSitePlus
K502 Acetylation PhosphoSitePlus
K502 Sumoylation PhosphoSitePlus
K502 Ubiquitination PhosphoSitePlus
K509 Ubiquitination PhosphoSitePlus
S513 Phosphorylation PhosphoSitePlus
S516 Phosphorylation PhosphoSitePlus
T524 Phosphorylation PhosphoSitePlus
S525 Phosphorylation PhosphoSitePlus
S526 Phosphorylation PhosphoSitePlus   UniProt 23186163
S529 Phosphorylation PhosphoSitePlus
S546 Phosphorylation PhosphoSitePlus
S548 Phosphorylation PhosphoSitePlus
S551 Phosphorylation PhosphoSitePlus
S553 Phosphorylation PhosphoSitePlus
K560 Ubiquitination PhosphoSitePlus
S561 Phosphorylation PhosphoSitePlus   UniProt 23186163
S568 Phosphorylation HPRD   PhosphoSitePlus 18077418
K569 Ubiquitination PhosphoSitePlus
S570 Phosphorylation PhosphoSitePlus
S571 Phosphorylation HPRD   PhosphoSitePlus 17525332, 18077418
S574 Phosphorylation PhosphoSitePlus
K582 Ubiquitination PhosphoSitePlus
K586 Sumoylation PhosphoSitePlus
K586 Ubiquitination PhosphoSitePlus
S592 Phosphorylation HPRD   PhosphoSitePlus 19413330
S670 Phosphorylation PhosphoSitePlus
K674 Methylation PhosphoSitePlus
K698 Ubiquitination PhosphoSitePlus
K701 Ubiquitination PhosphoSitePlus
K708 Ubiquitination PhosphoSitePlus
K710 Ubiquitination PhosphoSitePlus
S713 Phosphorylation PhosphoSitePlus
S714 Phosphorylation PhosphoSitePlus
S716 Phosphorylation HPRD   PhosphoSitePlus 19413330
S717 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 20068231
S719 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 19007248, 19664995, ...18669648, 20068231
S721 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 23186163, 20068231
K722 Acetylation PhosphoSitePlus
K722 Ubiquitination PhosphoSitePlus
S726 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K97 R97 Biomuta DOID:363 / uterine cancer [ tcga ]
K97 N97 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
Y99 * Biomuta DOID:1909 / melanoma [ tcga ]
K142 R142 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
Y171 N171 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
K173 N173 Biomuta DOID:263 / kidney cancer [ cosmic, icgc, tcga ]
S252 Y252 Biomuta DOID:3571 / liver cancer [ icgc ]
S276 F276 Biomuta DOID:11934 / head and neck cancer [ tcga ]
K292 N292 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:1909 / melanoma [ cosmic ]
K371 Q371 Biomuta DOID:1324 / lung cancer [ cosmic ]
S442 Y442 Biomuta DOID:9256 / colorectal cancer [ tcga ]
K502 * Biomuta DOID:1790 / malignant mesothelioma [ tcga ]
S513 Y513 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S526 I526 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S529 L529 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S546 L546 Biomuta DOID:11934 / head and neck cancer [ tcga ]
S546 P546 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S548 L548 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S553 N553 Biomuta DOID:363 / uterine cancer [ tcga ]
S553 I553 Biomuta DOID:363 / uterine cancer [ tcga ]
S568 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
K582 T582 Biomuta DOID:363 / uterine cancer [ tcga ]
K708 R708 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
K708 E708 Biomuta DOID:1612 / breast cancer [ tcga ]
S713 R713 Biomuta DOID:3571 / liver cancer [ icgc ]
S717 G717 Biomuta DOID:1909 / melanoma [ cosmic ]
S721 L721 Biomuta DOID:1324 / lung cancer [ cosmic ]