iPTMnet Report for Q5VZ89 (DENND4C)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q5VZ89 / DEN4C_HUMAN
Protein Name DENN domain-containing protein 4C
Gene Name Name: DENND4C
Synonyms:C9orf55,C9orf55B;
Organism Homo sapiens (Human)

PRO ID PR:Q5VZ89
DAG View
PRO Name DENN domain-containing protein 4C (human)
Definition A DENN domain-containing protein 4C that is encoded in the genome of human.
Short Label hDENND4C
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q5VZ89 (DENND4C) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K287 Ubiquitination PhosphoSitePlus
T296 Phosphorylation PhosphoSitePlus
C452 Methylation IEDB 31844290
K506 Acetylation PhosphoSitePlus
K510 Acetylation PhosphoSitePlus
C513 Methylation IEDB 31844290
Y524 Phosphorylation PhosphoSitePlus
S528 Phosphorylation PhosphoSitePlus
S538 Phosphorylation PhosphoSitePlus
K591 Ubiquitination PhosphoSitePlus
Y612 Phosphorylation PhosphoSitePlus
C648 Methylation IEDB 31844290
K651 Ubiquitination PhosphoSitePlus
S680 Phosphorylation PhosphoSitePlus
S703 Phosphorylation PhosphoSitePlus   UniProt 23186163
K717 Ubiquitination PhosphoSitePlus
T734 Phosphorylation PhosphoSitePlus
S737 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
T739 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K740 Ubiquitination PhosphoSitePlus
S741 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163
T755 Phosphorylation PhosphoSitePlus
T765 Phosphorylation phospho.ELM 18669648, 17081983
S868 Phosphorylation PhosphoSitePlus
S873 Phosphorylation PhosphoSitePlus
S905 Phosphorylation PhosphoSitePlus
S908 Phosphorylation PhosphoSitePlus
S911 Phosphorylation PhosphoSitePlus
T945 Phosphorylation PhosphoSitePlus
T947 Phosphorylation PhosphoSitePlus
E953 Phosphorylation UniProt 20068231, 24275569
C955 Methylation IEDB 31844290
S965 Phosphorylation PhosphoSitePlus   UniProt 18669648, 24275569
S968 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163, 24275569
S973 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163, 19690332, ...24275569
T975 Phosphorylation PhosphoSitePlus   UniProt 24275569
S982 Phosphorylation PhosphoSitePlus
S989 Phosphorylation P28482 (MAPK1) neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 22028470, 23186163, 18669648, ...24275569, 19690332
S996 Phosphorylation PhosphoSitePlus   UniProt 23186163
S999 Phosphorylation PhosphoSitePlus
S1000 Phosphorylation PhosphoSitePlus
T1001 Phosphorylation PhosphoSitePlus
S1003 Phosphorylation PhosphoSitePlus   UniProt 18669648
S1005 Phosphorylation PhosphoSitePlus
R1036 Methylation PhosphoSitePlus
S1046 Phosphorylation PhosphoSitePlus   UniProt 18669648
S1048 Phosphorylation PhosphoSitePlus
S1049 Phosphorylation PhosphoSitePlus
S1060 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1061 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1064 Phosphorylation PhosphoSitePlus
S1067 Phosphorylation PhosphoSitePlus
T1085 Phosphorylation PhosphoSitePlus
S1090 Phosphorylation PhosphoSitePlus
T1097 Phosphorylation PhosphoSitePlus
S1099 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163
S1115 Phosphorylation PhosphoSitePlus
S1125 Phosphorylation PhosphoSitePlus
S1126 Phosphorylation PhosphoSitePlus   UniProt 18669648
S1135 Phosphorylation PhosphoSitePlus
T1149 O-Glycosylation GlyGen 32938750
Y1156 Phosphorylation PhosphoSitePlus
S1158 Phosphorylation PhosphoSitePlus
S1163 Phosphorylation PhosphoSitePlus
S1165 Phosphorylation PhosphoSitePlus
S1183 Phosphorylation PhosphoSitePlus
S1184 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163
Y1186 Phosphorylation PhosphoSitePlus
T1212 Phosphorylation PhosphoSitePlus
K1215 Ubiquitination PhosphoSitePlus
T1216 Phosphorylation PhosphoSitePlus
S1219 Phosphorylation PhosphoSitePlus
S1225 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S1238 Phosphorylation PhosphoSitePlus
Y1239 Phosphorylation PhosphoSitePlus
K1243 Methylation PhosphoSitePlus
S1244 Phosphorylation PhosphoSitePlus   UniProt 18669648
S1248 Phosphorylation PhosphoSitePlus
K1249 Ubiquitination PhosphoSitePlus
S1250 Phosphorylation PhosphoSitePlus
S1252 Phosphorylation PhosphoSitePlus
S1277 Phosphorylation PhosphoSitePlus
S1278 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163, 19690332, ...24275569
S1285 Phosphorylation PhosphoSitePlus
S1293 Phosphorylation PhosphoSitePlus
K1295 Ubiquitination PhosphoSitePlus
S1296 Phosphorylation PhosphoSitePlus
S1297 Phosphorylation PhosphoSitePlus
S1301 Phosphorylation PhosphoSitePlus
K1304 Ubiquitination PhosphoSitePlus
T1305 Phosphorylation PhosphoSitePlus
K1311 Acetylation PhosphoSitePlus
T1314 Phosphorylation PhosphoSitePlus
S1323 Phosphorylation PhosphoSitePlus
T1324 Phosphorylation PhosphoSitePlus
S1325 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163
S1327 Phosphorylation PhosphoSitePlus
S1332 Phosphorylation PhosphoSitePlus
S1333 Phosphorylation PhosphoSitePlus
S1337 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1340 Phosphorylation PhosphoSitePlus
S1344 Phosphorylation PhosphoSitePlus
S1346 Phosphorylation PhosphoSitePlus   UniProt 23186163, 19690332
K1349 Ubiquitination PhosphoSitePlus
S1355 Phosphorylation PhosphoSitePlus
K1358 Ubiquitination PhosphoSitePlus
K1363 Ubiquitination PhosphoSitePlus
S1364 Phosphorylation PhosphoSitePlus
K1367 Ubiquitination PhosphoSitePlus
T1371 Phosphorylation PhosphoSitePlus
S1374 Phosphorylation PhosphoSitePlus
S1387 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1466 Phosphorylation PhosphoSitePlus
S1490 Phosphorylation PhosphoSitePlus
S1553 Phosphorylation PhosphoSitePlus
S1556 Phosphorylation PhosphoSitePlus
S1559 Phosphorylation PhosphoSitePlus
T1599 Phosphorylation PhosphoSitePlus
S1601 Phosphorylation PhosphoSitePlus
K1610 Ubiquitination PhosphoSitePlus
S1613 Phosphorylation PhosphoSitePlus
S1623 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S1627 Phosphorylation PhosphoSitePlus   UniProt 18669648
S1629 Phosphorylation PhosphoSitePlus   UniProt 23186163
K1630 Ubiquitination PhosphoSitePlus
S1634 Phosphorylation PhosphoSitePlus
S1638 Phosphorylation PhosphoSitePlus
S1640 Phosphorylation PhosphoSitePlus
T1651 Phosphorylation PhosphoSitePlus
S1659 Phosphorylation PhosphoSitePlus
T1660 Phosphorylation PhosphoSitePlus
S1662 Phosphorylation PhosphoSitePlus
S1666 Phosphorylation PhosphoSitePlus
S1763 Phosphorylation PhosphoSitePlus
Y1786 Phosphorylation PhosphoSitePlus
K1797 Ubiquitination PhosphoSitePlus
S1798 Phosphorylation PhosphoSitePlus
S1799 Phosphorylation PhosphoSitePlus   UniProt 24275569
S1802 Phosphorylation PhosphoSitePlus
T1808 Phosphorylation PhosphoSitePlus
K1826 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T924 Phosphorylation PhosphoSitePlus
S929 Phosphorylation PhosphoSitePlus
S932 Phosphorylation PhosphoSitePlus
S953 Phosphorylation PhosphoSitePlus
S1327 Phosphorylation PhosphoSitePlus
S1345 Phosphorylation PhosphoSitePlus
S1687 Phosphorylation PhosphoSitePlus
S1689 Phosphorylation PhosphoSitePlus
S1711 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T296 M296 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:10283 / prostate cancer [ cosmic ]
K506 N506 Biomuta DOID:4159 / skin cancer [ cosmic ]
K510 T510 Biomuta DOID:1324 / lung cancer [ cosmic ]
C513 W513 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
C513 F513 Biomuta DOID:1324 / lung cancer [ cosmic ]
S538 A538 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
C648 Y648 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S703 P703 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10283 / prostate cancer [ cosmic ]
S737 R737 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S868 I868 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S873 N873 Biomuta DOID:4159 / skin cancer [ cosmic ]
S908 P908 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S908 C908 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
T924 M924 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S968 I968 Biomuta DOID:3571 / liver cancer [ cosmic ]
S1000 G1000 Biomuta DOID:263 / kidney cancer [ cosmic ]
S1003 R1003 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1064 L1064 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1115 F1115 Biomuta [ cosmic ]
Y1156 C1156 Biomuta DOID:3571 / liver cancer [ cosmic ]
S1165 I1165 Biomuta DOID:363 / uterine cancer [ icgc ]
S1184 T1184 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S1244 R1244 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S1248 C1248 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1277 * Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S1277 L1277 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1278 R1278 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S1278 C1278 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
K1295 N1295 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K1304 T1304 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
T1305 N1305 Biomuta DOID:3571 / liver cancer [ cosmic ]
T1324 I1324 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1325 F1325 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1325 Y1325 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S1327 C1327 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S1327 R1327 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S1327 L1327 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S1340 F1340 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1364 T1364 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1553 Y1553 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1553 C1553 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S1601 C1601 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
K1610 Q1610 Biomuta DOID:3571 / liver cancer [ cosmic ]
T1660 A1660 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S1763 I1763 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S1798 L1798 Biomuta DOID:5041 / esophageal cancer [ cosmic ]