iPTMnet Report for Q5VZ18 (SHE)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q5VZ18 / SHE_HUMAN
Protein Name SH2 domain-containing adapter protein E
Gene Name Name: SHE
Organism Homo sapiens (Human)

PRO ID PR:Q5VZ18
DAG View
PRO Name SH2 domain-containing adapter protein E (human)
Definition An SH2 domain-containing adapter protein E that is encoded in the genome of human.
Short Label hSHE
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q5VZ18 (SHE) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K50 Acetylation PhosphoSitePlus
T51 Phosphorylation PhosphoSitePlus
S53 O-Glycosylation GlyGen 34105348
K64 Ubiquitination PhosphoSitePlus
S69 Phosphorylation PhosphoSitePlus
S85 Phosphorylation PhosphoSitePlus
K118 Acetylation PhosphoSitePlus
S123 Phosphorylation PhosphoSitePlus
T126 Phosphorylation PhosphoSitePlus
S164 Phosphorylation PhosphoSitePlus
S165 Phosphorylation PhosphoSitePlus
S166 Phosphorylation PhosphoSitePlus
S167 Phosphorylation PhosphoSitePlus
S168 Phosphorylation PhosphoSitePlus
S172 Phosphorylation PhosphoSitePlus
S180 Phosphorylation PhosphoSitePlus
S181 Phosphorylation PhosphoSitePlus
Y204 Phosphorylation PhosphoSitePlus
Y228 Phosphorylation PhosphoSitePlus
S246 Phosphorylation PhosphoSitePlus
Y290 Phosphorylation PhosphoSitePlus
S312 Phosphorylation PhosphoSitePlus
S341 Phosphorylation PhosphoSitePlus
S376 Phosphorylation PhosphoSitePlus
Y452 Phosphorylation PhosphoSitePlus
Y470 Phosphorylation PhosphoSitePlus
Y471 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T126 M126 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S166 I166 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S180 F180 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic ]
S181 F181 Biomuta [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
Y204 H204 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
Y228 C228 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ]
S341 L341 Biomuta DOID:4159 / skin cancer [ cosmic ]
S376 L376 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]