iPTMnet Report for Q5VY43 (PEAR1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q5VY43 / PEAR1_HUMAN
Protein Name Platelet endothelial aggregation receptor 1 precursor
Gene Name Name: PEAR1
Synonyms:MEGF12;
Organism Homo sapiens (Human)

PRO ID PR:Q5VY43
DAG View
PRO Name platelet endothelial aggregation receptor 1 (human)
Definition A platelet endothelial aggregation receptor 1 that is encoded in the genome of human.
Short Label hPEAR1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q5VY43 (PEAR1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T64 O-Glycosylation GlyGen 30459171
K81 Acetylation PhosphoSitePlus
S795 Phosphorylation PhosphoSitePlus
Y890 Phosphorylation PhosphoSitePlus
S891 Phosphorylation PhosphoSitePlus
S893 Phosphorylation PhosphoSitePlus
Y925 Phosphorylation HPRD   PhosphoSitePlus   RLIMS-P   UniProt 15851471
S953 Phosphorylation HPRD   PhosphoSitePlus   RLIMS-P   UniProt 15851471
S964 Phosphorylation PhosphoSitePlus
Y1019 Phosphorylation PhosphoSitePlus
S1029 Phosphorylation HPRD   PhosphoSitePlus   RLIMS-P   UniProt 15851471
Site PTM Type PTM Enzyme Score Source PMID
Y925 Phosphorylation PRO 15851471
S953 Phosphorylation PRO 15851471
S1029 Phosphorylation PRO 15851471


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000025639 (hPEAR1/iso:1/Phos:1) pY925,pS953,pS1029 PRO 15851471


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000025639 (hPEAR1/iso:1/Phos:1) Interaction PR:P29353 (hSHC1) PRO 15851471
PR:000025639 (hPEAR1/iso:1/Phos:1) Interaction PR:P98077 (hSHC2) PRO 15851471


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S795 N795 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S891 N891 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ]
S893 R893 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y1019 N1019 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]