iPTMnet Report for Q5VV42 (CDKAL1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q5VV42 / CDKAL_HUMAN
Protein Name Threonylcarbamoyladenosine tRNA methylthiotransferase
Gene Name Name: CDKAL1
Organism Homo sapiens (Human)

PRO ID PR:Q5VV42
DAG View
PRO Name threonylcarbamoyladenosine tRNA methylthiotransferase (human)
Definition A threonylcarbamoyladenosine tRNA methylthiotransferase that is encoded in the genome of human.
Short Label hCDKAL1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q5VV42 (CDKAL1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K37 Ubiquitination PhosphoSitePlus
T43 Phosphorylation PhosphoSitePlus
K45 Ubiquitination PhosphoSitePlus
Y46 Phosphorylation PhosphoSitePlus
S53 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S56 Phosphorylation PhosphoSitePlus
S58 Phosphorylation PhosphoSitePlus
K65 Ubiquitination PhosphoSitePlus
S99 Phosphorylation PhosphoSitePlus
S108 O-Glycosylation GlyGen 33465208
K112 Ubiquitination PhosphoSitePlus
S122 Phosphorylation PhosphoSitePlus   UniProt 23186163
K124 Ubiquitination PhosphoSitePlus
K132 Ubiquitination PhosphoSitePlus
K150 Ubiquitination PhosphoSitePlus
T170 Phosphorylation PhosphoSitePlus
K172 Ubiquitination PhosphoSitePlus
S175 Phosphorylation PhosphoSitePlus
K198 Ubiquitination PhosphoSitePlus
K243 Ubiquitination PhosphoSitePlus
K307 Ubiquitination PhosphoSitePlus
Y315 Phosphorylation PhosphoSitePlus
K343 Ubiquitination PhosphoSitePlus
K350 Ubiquitination PhosphoSitePlus
K352 Ubiquitination PhosphoSitePlus
K404 Ubiquitination PhosphoSitePlus
K433 Ubiquitination PhosphoSitePlus
K484 Ubiquitination PhosphoSitePlus
K488 Ubiquitination PhosphoSitePlus
K496 Ubiquitination PhosphoSitePlus
T499 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
K504 Ubiquitination PhosphoSitePlus
K508 Ubiquitination PhosphoSitePlus
K516 Ubiquitination PhosphoSitePlus
S527 Phosphorylation PhosphoSitePlus
S530 Phosphorylation PhosphoSitePlus
S536 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S53 Phosphorylation HPRD 18669648
T499 Phosphorylation HPRD 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K45 N45 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K65 R65 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S122 L122 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S122 * Biomuta DOID:4159 / skin cancer [ cosmic ]
K150 E150 Biomuta DOID:184 / bone cancer [ cosmic ]
K198 N198 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
Y315 S315 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
K350 R350 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]