iPTMnet Report for Q5VUJ6 (LRCH2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q5VUJ6 / LRCH2_HUMAN
Protein Name Leucine-rich repeat and calponin homology domain-containing protein 2
Gene Name Name: LRCH2
Synonyms:KIAA1495;
Organism Homo sapiens (Human)

PRO ID PR:Q5VUJ6
DAG View
PRO Name leucine-rich repeat and calponin homology domain-containing protein 2 (human)
Definition A leucine-rich repeat and calponin homology domain-containing protein 2 that is encoded in the genome of human.
Short Label hLRCH2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q5VUJ6 (LRCH2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y161 Phosphorylation PhosphoSitePlus
T171 Phosphorylation PhosphoSitePlus
S315 Phosphorylation PhosphoSitePlus
S333 Phosphorylation PhosphoSitePlus
S351 Phosphorylation PhosphoSitePlus
S359 Phosphorylation PhosphoSitePlus
S364 Phosphorylation PhosphoSitePlus
S521 Phosphorylation PhosphoSitePlus
S589 Phosphorylation PhosphoSitePlus
Y626 Phosphorylation PhosphoSitePlus
T634 Phosphorylation PhosphoSitePlus
R636 Methylation PhosphoSitePlus
R637 Methylation PhosphoSitePlus
K638 Methylation PhosphoSitePlus
R643 Methylation PhosphoSitePlus
S689 Phosphorylation PhosphoSitePlus
S692 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S315 F315 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic, icgc ]
S315 T315 Biomuta DOID:4159 / skin cancer [ cosmic ]
S333 C333 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S351 I351 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S589 L589 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
R637 I637 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
R643 Q643 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
R643 W643 Biomuta DOID:1319 / brain cancer [ cosmic ]