iPTMnet Report for Q5VTR2 (RNF20)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q5VTR2 / BRE1A_HUMAN
Protein Name E3 ubiquitin-protein ligase BRE1A
Gene Name Name: RNF20
Synonyms:BRE1A;
Organism Homo sapiens (Human)

PRO ID PR:Q5VTR2
DAG View
PRO Name E3 ubiquitin-protein ligase BRE1A (human)
Definition An E3 ubiquitin-protein ligase BRE1A that is encoded in the genome of human.
Short Label hRNF20
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q5VTR2 (RNF20) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation HPRD 20068231
S16 Phosphorylation HPRD 20068231
T31 Phosphorylation HPRD 20068231
T34 Phosphorylation HPRD   PhosphoSitePlus 20068231
S41 Phosphorylation PhosphoSitePlus   UniProt 23186163
S42 Phosphorylation PhosphoSitePlus
T43 Phosphorylation PhosphoSitePlus
K57 Ubiquitination PhosphoSitePlus
T122 Phosphorylation HPRD   PhosphoSitePlus 20068231
K125 Ubiquitination PhosphoSitePlus
S136 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 18491316, 23186163, ...17081983, 20230923, 20058876, 19664995, 18452278, 19651622, 18669648, 24275569, 19690332, 20068231, 18212344
S138 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 21406692, 23186163, ...17081983, 20230923, 20058876, 15302935, 19664995, 18452278, 19651622, 19664994, 18669648, 19415658, 17322306, 24275569, 18767875, 19690332, 20068231
S172 Phosphorylation Q13315 (ATM) PhosphoSitePlus 21362549
K194 Ubiquitination PhosphoSitePlus
T236 O-Glycosylation GlyGen 23301498, 30379171, 34019948, ...28510447, 33465208
K242 Ubiquitination PhosphoSitePlus
K256 Ubiquitination PhosphoSitePlus
T259 O-Glycosylation GlyGen 23301498, 30379171, 34019948, ...28510447, 33465208
S262 Phosphorylation PhosphoSitePlus
S265 Phosphorylation PhosphoSitePlus
S269 Phosphorylation PhosphoSitePlus
Y314 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
T317 Phosphorylation HPRD 20068231
K324 Sumoylation PhosphoSitePlus
K348 Acetylation PhosphoSitePlus   UniProt 19608861
K348 Ubiquitination PhosphoSitePlus
K376 Ubiquitination PhosphoSitePlus
T444 Phosphorylation PhosphoSitePlus
K450 Ubiquitination PhosphoSitePlus
S515 Phosphorylation PhosphoSitePlus
S517 Phosphorylation PhosphoSitePlus
S522 Phosphorylation Q13315 (ATM) HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17478428, 18669648, 20068231
S524 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19651622, 18669648, 18452278
S525 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19651622, 18669648, 20068231, ...18452278
T526 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 18452278
S540 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17525332
S545 Phosphorylation Q13315 (ATM) HPRD   phospho.ELM   PhosphoSitePlus 17478428, 17525332
S548 Phosphorylation PhosphoSitePlus
S550 Phosphorylation PhosphoSitePlus
S553 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17525332
K610 Methylation PhosphoSitePlus
K614 Methylation PhosphoSitePlus
Y650 Phosphorylation PhosphoSitePlus
K716 Ubiquitination PhosphoSitePlus
K762 Ubiquitination PhosphoSitePlus
K769 Methylation PhosphoSitePlus
K775 Ubiquitination PhosphoSitePlus
K778 Sumoylation PhosphoSitePlus
K808 Acetylation PhosphoSitePlus
K808 Ubiquitination PhosphoSitePlus
K821 Ubiquitination PhosphoSitePlus
K857 Ubiquitination PhosphoSitePlus
K872 Ubiquitination PhosphoSitePlus
K874 Acetylation PhosphoSitePlus
K880 Acetylation PhosphoSitePlus
K880 Methylation PhosphoSitePlus
K929 Ubiquitination PhosphoSitePlus
K930 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S2 P2 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S2 L2 Biomuta DOID:4159 / skin cancer [ cosmic ]
T31 A31 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S42 T42 Biomuta DOID:4159 / skin cancer [ cosmic, icgc, tcga ]
K242 N242 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T259 I259 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S269 Y269 Biomuta DOID:363 / uterine cancer [ icgc ]
K450 N450 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S515 N515 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S522 P522 Biomuta DOID:263 / kidney cancer [ cosmic ]
S522 F522 Biomuta DOID:2394 / ovarian cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ]
S525 N525 Biomuta DOID:363 / uterine cancer [ icgc ]
S540 F540 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:2174 / ocular cancer [ cosmic ]
K610 I610 Biomuta DOID:4159 / skin cancer [ cosmic ]
K769 N769 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K857 T857 Biomuta DOID:363 / uterine cancer [ icgc ]
K872 T872 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K929 T929 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K929 N929 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K930 Q930 Biomuta DOID:9256 / colorectal cancer [ cosmic ]