iPTMnet Report for Q5VTB9 (RNF220)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q5VTB9 / RN220_HUMAN
Protein Name E3 ubiquitin-protein ligase RNF220
Gene Name Name: RNF220
Synonyms:C1orf164;
Organism Homo sapiens (Human)

PRO ID PR:Q5VTB9
DAG View
PRO Name E3 ubiquitin-protein ligase RNF220 (human)
Definition An E3 ubiquitin-protein ligase RNF220 that is encoded in the genome of human.
Short Label hRNF220
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q5VTB9 (RNF220) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S53 O-Glycosylation GlyGen 35289036, 28657654, 35254053
K140 Acetylation PhosphoSitePlus
S150 Phosphorylation PhosphoSitePlus
S173 Phosphorylation PhosphoSitePlus
S194 Phosphorylation PhosphoSitePlus
R196 Methylation PhosphoSitePlus
S200 Phosphorylation PhosphoSitePlus
S201 Phosphorylation PhosphoSitePlus
S269 Phosphorylation PhosphoSitePlus
S273 Phosphorylation PhosphoSitePlus
S275 Phosphorylation PhosphoSitePlus
K277 Sumoylation PhosphoSitePlus
S282 Phosphorylation PhosphoSitePlus
S286 Phosphorylation PhosphoSitePlus
S290 Phosphorylation PhosphoSitePlus
Y356 Phosphorylation PhosphoSitePlus
K362 Acetylation PhosphoSitePlus
K362 Ubiquitination PhosphoSitePlus
S390 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
K426 Ubiquitination PhosphoSitePlus
T446 Phosphorylation PhosphoSitePlus
K451 Ubiquitination PhosphoSitePlus
K496 Ubiquitination PhosphoSitePlus
C530 Methylation IEDB 31844290
Site PTM Type PTM Enzyme Score Source PMID
S173 Phosphorylation HPRD 19413330
S289 Phosphorylation HPRD 17081983
T292 Phosphorylation HPRD 17081983
S390 Phosphorylation HPRD 19651622, 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R196 W196 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S201 I201 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S269 Y269 Biomuta DOID:4362 / cervical cancer [ icgc ]
S273 Y273 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
K277 N277 Biomuta DOID:4159 / skin cancer [ cosmic ]
S290 F290 Biomuta DOID:4159 / skin cancer [ cosmic ]
K496 M496 Biomuta DOID:9256 / colorectal cancer [ cosmic ]