iPTMnet Report for Q5VT97 (SYDE2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q5VT97 / SYDE2_HUMAN
Protein Name Rho GTPase-activating protein SYDE2
Gene Name Name: SYDE2
Organism Homo sapiens (Human)

PRO ID PR:Q5VT97
DAG View
PRO Name Rho GTPase-activating protein SYDE2 (human)
Definition A Rho GTPase-activating protein SYDE2 that is encoded in the genome of human.
Short Label hSYDE2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q5VT97 (SYDE2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R12 Methylation PhosphoSitePlus
R15 Methylation PhosphoSitePlus
R35 Methylation PhosphoSitePlus
S60 Phosphorylation PhosphoSitePlus
S64 Phosphorylation PhosphoSitePlus
S82 O-Glycosylation GlyGen 30379171
S86 Phosphorylation PhosphoSitePlus
S104 Phosphorylation PhosphoSitePlus
S106 Phosphorylation PhosphoSitePlus
T187 Phosphorylation PhosphoSitePlus
T217 Phosphorylation PhosphoSitePlus
T219 Phosphorylation PhosphoSitePlus
S223 Phosphorylation PhosphoSitePlus
K230 Ubiquitination PhosphoSitePlus
T246 Phosphorylation PhosphoSitePlus
K260 Ubiquitination PhosphoSitePlus
K268 Ubiquitination PhosphoSitePlus
K277 Ubiquitination PhosphoSitePlus
Y292 Phosphorylation PhosphoSitePlus
S315 Phosphorylation PhosphoSitePlus   UniProt 23186163
S317 Phosphorylation PhosphoSitePlus   UniProt 23186163
S329 Phosphorylation PhosphoSitePlus
K332 Methylation PhosphoSitePlus
K332 Ubiquitination PhosphoSitePlus
S333 Phosphorylation PhosphoSitePlus
K335 Methylation PhosphoSitePlus
T434 Phosphorylation PhosphoSitePlus
T435 Phosphorylation PhosphoSitePlus
S510 Phosphorylation PhosphoSitePlus
S522 Phosphorylation PhosphoSitePlus
T525 O-Glycosylation GlyGen 30379171
S554 Phosphorylation PhosphoSitePlus
S597 Phosphorylation PhosphoSitePlus
S599 Phosphorylation PhosphoSitePlus
S622 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163, 21406692, ...19690332
S626 Phosphorylation PhosphoSitePlus
K655 Ubiquitination PhosphoSitePlus
T906 Phosphorylation PhosphoSitePlus
Y910 Phosphorylation PhosphoSitePlus
T974 Phosphorylation PhosphoSitePlus
T995 Phosphorylation PhosphoSitePlus
S1082 Phosphorylation PhosphoSitePlus
Y1126 Phosphorylation PhosphoSitePlus
S1127 Phosphorylation PhosphoSitePlus
S1193 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S622 Phosphorylation HPRD 18669648, 19664994


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S223 P223 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T246 K246 Biomuta DOID:3571 / liver cancer [ cosmic ]
S315 F315 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ] DOID:8618 / oral cavity cancer [ cosmic ]
S329 Y329 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K335 T335 Biomuta DOID:363 / uterine cancer [ icgc ]
S522 Y522 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S599 F599 Biomuta DOID:4159 / skin cancer [ cosmic ]
S626 P626 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K655 N655 Biomuta DOID:9256 / colorectal cancer [ icgc ]
T974 A974 Biomuta DOID:9256 / colorectal cancer [ cosmic ]