Protein Information

Cytoscape View


UniProt AC / UniProt ID Q5VT25 / MRCKA_HUMAN
Protein Name Serine/threonine-protein kinase MRCK alpha
Gene Name Name: CDC42BPA
Synonyms:KIAA0451;
Organism Homo sapiens (Human)

PRO ID PR:Q5VT25
DAG View
PRO Name serine/threonine-protein kinase MRCK alpha (human)
Definition A serine/threonine-protein kinase MRCK alpha that is encoded in the genome of human.
Short Label hCDC42BPA
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q5VT25 (CDC42BPA) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation PhosphoSitePlus
T119 Phosphorylation PhosphoSitePlus
R172 Methylation PhosphoSitePlus
R179 Methylation PhosphoSitePlus
S222 Phosphorylation Q5VT25 (CDC42BPA) neXtProt   PhosphoSitePlus   UniProt 11283256
S234 Phosphorylation Q5VT25 (CDC42BPA) neXtProt   PhosphoSitePlus   UniProt 11283256
T240 Phosphorylation Q5VT25 (CDC42BPA) neXtProt   PhosphoSitePlus   UniProt 11283256
K338 Ubiquitination PhosphoSitePlus
K339 Ubiquitination PhosphoSitePlus
T403 Phosphorylation Q5VT25 (CDC42BPA) neXtProt   PhosphoSitePlus 11283256
Y444 Phosphorylation PhosphoSitePlus
K455 Ubiquitination PhosphoSitePlus
K461 Ubiquitination PhosphoSitePlus
Y474 Phosphorylation PhosphoSitePlus
S475 Phosphorylation PhosphoSitePlus
K490 Ubiquitination PhosphoSitePlus
K531 Ubiquitination PhosphoSitePlus
K669 Acetylation PhosphoSitePlus
K669 Ubiquitination PhosphoSitePlus
S674 Phosphorylation PhosphoSitePlus
S679 Phosphorylation PhosphoSitePlus
T687 Phosphorylation PhosphoSitePlus
S725 Phosphorylation PhosphoSitePlus
S750 Phosphorylation PhosphoSitePlus
K785 Ubiquitination PhosphoSitePlus
S843 Phosphorylation PhosphoSitePlus
T846 Phosphorylation PhosphoSitePlus
S856 Phosphorylation PhosphoSitePlus
T862 Phosphorylation PhosphoSitePlus
K893 Ubiquitination PhosphoSitePlus
K913 Ubiquitination PhosphoSitePlus
K920 Ubiquitination PhosphoSitePlus
S940 Phosphorylation PhosphoSitePlus
S989 Phosphorylation PhosphoSitePlus
T992 Phosphorylation PhosphoSitePlus
T994 Phosphorylation PhosphoSitePlus
S1003 Phosphorylation PhosphoSitePlus   RLIMS-P 30667325, 29382705
K1079 Ubiquitination PhosphoSitePlus
K1122 Ubiquitination PhosphoSitePlus
S1171 Phosphorylation PhosphoSitePlus
S1173 Phosphorylation PhosphoSitePlus
T1185 Phosphorylation PhosphoSitePlus
K1217 Ubiquitination PhosphoSitePlus
K1228 Ubiquitination PhosphoSitePlus
K1307 Ubiquitination PhosphoSitePlus
K1312 Ubiquitination PhosphoSitePlus
S1378 Phosphorylation PhosphoSitePlus
T1505 Phosphorylation PhosphoSitePlus
Y1510 Phosphorylation PhosphoSitePlus
Y1544 Phosphorylation PhosphoSitePlus
S1545 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S1604 Phosphorylation PhosphoSitePlus
S1609 O-Glycosylation GlyGen 28657654
S1611 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1613 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1616 Phosphorylation PhosphoSitePlus
T1618 Phosphorylation PhosphoSitePlus
S1629 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1632 Phosphorylation PhosphoSitePlus
S1635 Phosphorylation PhosphoSitePlus
S1639 Phosphorylation PhosphoSitePlus
S1644 Phosphorylation PhosphoSitePlus
S1651 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163
S1654 Phosphorylation PhosphoSitePlus
S1656 Phosphorylation PhosphoSitePlus
S1664 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1669 Phosphorylation PhosphoSitePlus   UniProt 24275569
S1693 Phosphorylation PhosphoSitePlus   UniProt 24275569
S1700 Phosphorylation PhosphoSitePlus
S1703 Phosphorylation PhosphoSitePlus
S1706 Phosphorylation PhosphoSitePlus
S1710 Phosphorylation PhosphoSitePlus
S1719 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S1721 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S1724 Phosphorylation PhosphoSitePlus
T1725 Phosphorylation PhosphoSitePlus
S1729 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S992 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation HPRD 20068231
T765 Phosphorylation HPRD 19664994
K861 Ubiquitination PhosphoSitePlus
T1411 Phosphorylation HPRD 20068231
Y1416 Phosphorylation HPRD 20068231
S1451 Phosphorylation HPRD 18669648
S1557 Phosphorylation HPRD 19651622
S1560 Phosphorylation HPRD 19651622
S1625 Phosphorylation HPRD 18669648
S1627 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation HPRD 20068231
T846 Phosphorylation HPRD 19664994
T1492 Phosphorylation HPRD 20068231
Y1497 Phosphorylation HPRD 20068231
S1532 Phosphorylation HPRD 18669648
S1638 Phosphorylation HPRD 19651622
S1641 Phosphorylation HPRD 19651622
S1706 Phosphorylation HPRD 18669648
S1708 Phosphorylation HPRD 18669648


Q5VT25 (CDC42BPA) as PTM Enzyme



Substrate Site Score Source PMID
P10916 (MYL2) S19 HPRD 9418861
P24844 (MYL9) T19 Signor 19851336
P24844 (MYL9) S20 neXtProt   PhosphoSitePlus   Signor 19851336, 18854160, 21457715
P26038 (MSN) T558 neXtProt 10947843
P53667-1 (LIMK1) T508 HPRD 11340065, 10559936, 10652353
P53671-2 (LIMK2) T505 HPRD   neXtProt 11340065
P53671-1 (LIMK2) T526 HPRD 11340065
Q5VT25 (CDC42BPA) S222 neXtProt   UniProt 11283256
Q5VT25 (CDC42BPA) S234 neXtProt   PhosphoSitePlus   UniProt 11283256
Q5VT25 (CDC42BPA) T240 neXtProt   PhosphoSitePlus   UniProt 11283256
Q5VT25 (CDC42BPA) T403 neXtProt   PhosphoSitePlus 11283256
Q9BZL4-1 (PPP1R12C) T560 HPRD   neXtProt 11399775, 18077418


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S475 L475 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
S843 F843 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc, tcga ]
S1003 * Biomuta DOID:1612 / breast cancer [ tcga ]
S1171 L1171 Biomuta DOID:1324 / lung cancer [ cosmic ]
T1185 N1185 Biomuta DOID:363 / uterine cancer [ tcga ]
S1378 * Biomuta DOID:3571 / liver cancer [ icgc ]
T1505 N1505 Biomuta DOID:1793 / pancreatic cancer [ tcga ]
T1618 A1618 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S1632 N1632 Biomuta DOID:1909 / melanoma [ cosmic ]
S1664 F1664 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S1724 R1724 Biomuta DOID:3571 / liver cancer [ icgc ]
T1725 S1725 Biomuta DOID:9256 / colorectal cancer [ tcga ]