iPTMnet Report for Q5TH69 (ARFGEF3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q5TH69 / BIG3_HUMAN
Protein Name Brefeldin A-inhibited guanine nucleotide-exchange protein 3
Gene Name Name: ARFGEF3
Synonyms:BIG3,C6orf92,KIAA1244;
Organism Homo sapiens (Human)

PRO ID PR:Q5TH69
DAG View
PRO Name brefeldin A-inhibited guanine nucleotide-exchange protein 3 (human)
Definition A brefeldin A-inhibited guanine nucleotide-exchange protein 3 that is encoded in the genome of human.
Short Label hARFGEF3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q5TH69 (ARFGEF3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S15 Phosphorylation PhosphoSitePlus
S83 Phosphorylation PhosphoSitePlus
T86 Phosphorylation PhosphoSitePlus
Y124 Phosphorylation PhosphoSitePlus
S295 Phosphorylation PhosphoSitePlus
S305 Phosphorylation RLIMS-P 28555617
S399 Phosphorylation PhosphoSitePlus
S471 Phosphorylation PhosphoSitePlus
T491 Phosphorylation PhosphoSitePlus
S495 Phosphorylation PhosphoSitePlus
S538 Phosphorylation PhosphoSitePlus
S592 Phosphorylation PhosphoSitePlus
S597 Phosphorylation HPRD   PhosphoSitePlus 19664994
S610 Phosphorylation PhosphoSitePlus
S622 Phosphorylation PhosphoSitePlus
S632 Phosphorylation PhosphoSitePlus
S636 Phosphorylation PhosphoSitePlus
T643 Phosphorylation PhosphoSitePlus
T655 Phosphorylation PhosphoSitePlus
S659 Phosphorylation PhosphoSitePlus
S1061 Phosphorylation PhosphoSitePlus
S1066 Phosphorylation PhosphoSitePlus
R1093 Methylation PhosphoSitePlus
S1103 Phosphorylation PhosphoSitePlus
T1116 Phosphorylation PhosphoSitePlus
T1119 Phosphorylation PhosphoSitePlus
S1178 Phosphorylation PhosphoSitePlus
S1208 Phosphorylation RLIMS-P 28555617
S1323 Phosphorylation PhosphoSitePlus
S1635 Phosphorylation PhosphoSitePlus
S1649 Phosphorylation PhosphoSitePlus
S1651 Phosphorylation HPRD   PhosphoSitePlus 18691976
T1673 Phosphorylation PhosphoSitePlus
S1676 Phosphorylation PhosphoSitePlus
T1747 Phosphorylation PhosphoSitePlus
Y1761 Phosphorylation PhosphoSitePlus
S1763 Phosphorylation PhosphoSitePlus
S1848 Phosphorylation PhosphoSitePlus
S1856 Phosphorylation PhosphoSitePlus
S1857 Phosphorylation PhosphoSitePlus
S1888 Phosphorylation PhosphoSitePlus
S1951 Phosphorylation PhosphoSitePlus
T1960 Phosphorylation PhosphoSitePlus
S1962 Phosphorylation PhosphoSitePlus
S1967 Phosphorylation PhosphoSitePlus
S1969 Phosphorylation PhosphoSitePlus
S1976 Phosphorylation PhosphoSitePlus
S1978 Phosphorylation PhosphoSitePlus
S1991 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976, 19664994, 23186163
S2023 Phosphorylation PhosphoSitePlus
Y2029 Phosphorylation PhosphoSitePlus
S2061 Phosphorylation PhosphoSitePlus
S2079 Phosphorylation PhosphoSitePlus
S2081 Phosphorylation PhosphoSitePlus
S2095 Phosphorylation PhosphoSitePlus
S2097 Phosphorylation PhosphoSitePlus
T2098 Phosphorylation PhosphoSitePlus
S2100 Phosphorylation PhosphoSitePlus
S2101 Phosphorylation PhosphoSitePlus
S2103 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S83 C83 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc, tcga ]
S471 F471 Biomuta DOID:4159 / skin cancer [ cosmic ]
S538 L538 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ]
S610 F610 Biomuta [ cosmic ]
S622 P622 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S636 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S636 L636 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S636 P636 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T655 N655 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S1061 L1061 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
S1061 P1061 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S1061 * Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S1323 Y1323 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T1673 I1673 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T1747 M1747 Biomuta DOID:363 / uterine cancer [ icgc ]
S1763 F1763 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1856 P1856 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1888 T1888 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
T1960 N1960 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T1960 A1960 Biomuta DOID:1793 / pancreatic cancer [ icgc ]
S1967 N1967 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1991 I1991 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S2023 P2023 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y2029 C2029 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S2061 C2061 Biomuta DOID:3571 / liver cancer [ cosmic ]
S2079 F2079 Biomuta DOID:4159 / skin cancer [ cosmic ]
S2101 T2101 Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
S2103 C2103 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]