iPTMnet Report for Q5TCY1 (TTBK1)
Protein Information
| UniProt AC / UniProt ID | Q5TCY1 / TTBK1_HUMAN |
| Protein Name | Tau-tubulin kinase 1 |
| Gene Name | Name: TTBK1 Synonyms:BDTK,KIAA1855; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q5TCY1 |
| PRO Name | tau-tubulin kinase 1 (human) |
| Definition | A tau-tubulin kinase 1 that is encoded in the genome of human. |
| Short Label | hTTBK1 |
| Category | organism-gene |
DAG ViewQ5TCY1 (TTBK1) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| T12 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K75 | Acetylation | score1 | PhosphoSitePlus | |||
| K83 | Sumoylation | score1 | PhosphoSitePlus | |||
| Y169 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S432 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S433 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S456 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S459 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S463 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T464 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S627 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T629 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S630 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S654 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S693 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y695 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S790 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S800 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S943 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S944 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S1041 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T1152 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S1200 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T1202 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S1232 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S1246 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S1248 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S1253 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S1259 | Phosphorylation | score1 | PhosphoSitePlus |
Q5TCY1 (TTBK1) as PTM Enzyme
|
Substrate | Site | Score | Source | PMID |
|---|---|---|---|---|---|
| P07437 (TUBB) | S275 | score1 | HPRD | 7556643 | |
| P10636-8 (MAPT) | Y197 | score2 | PhosphoSitePlus | 16923168 | |
| P10636-8 (MAPT) | S198 | score2 | PhosphoSitePlus | 16923168 | |
| P10636-8 (MAPT) | S199 | score2 | PhosphoSitePlus | 16923168 | |
| P10636-8 (MAPT) | S202 | score2 | PhosphoSitePlus | 16923168 | |
| P10636-8 (MAPT) | S416 | score2 | PhosphoSitePlus | 16923168 | |
| P10636-8 (MAPT) | S422 | score2 | PhosphoSitePlus | 16923168 | |
| P10636-8 (MAPT) | T427 | score2 | PhosphoSitePlus | 16923168 | |
| P10636 (MAPT) | S515 | score1 | Signor | 16923168 | |
| P10636 (MAPT) | S516 | score1 | Signor | 16923168 | |
| P10636 (MAPT) | S519 | score1 | Signor | 16923168 | |
| P10636 (MAPT) | S739 | score1 | Signor | 16923168 | |
| Q13885 (TUBB2A) | S275 | score1 | HPRD | 7556643 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| Y169 | C169 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
| S432 | R432 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
| S463 | F463 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| S1232 | N1232 | Biomuta | DOID:11934 / head and neck cancer [ icgc ] |
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