iPTMnet Report for Q5TCX8 (MAP3K21)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q5TCX8 / M3K21_HUMAN
Protein Name Mitogen-activated protein kinase kinase kinase 21
Gene Name Name: MAP3K21
Synonyms:KIAA1804;
Organism Homo sapiens (Human)

PRO ID PR:Q5TCX8
DAG View
PRO Name mitogen-activated protein kinase kinase kinase 21 (human)
Definition A mitogen-activated protein kinase kinase kinase 21 that is encoded in the genome of human.
Short Label hMAP3K21
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q5TCX8 (MAP3K21) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y47 Phosphorylation PhosphoSitePlus
Y96 Phosphorylation PhosphoSitePlus
S105 Phosphorylation PhosphoSitePlus
S111 Phosphorylation PhosphoSitePlus
S114 Phosphorylation PhosphoSitePlus
S115 Phosphorylation PhosphoSitePlus
T142 Phosphorylation PhosphoSitePlus
K286 Ubiquitination PhosphoSitePlus
K454 Ubiquitination PhosphoSitePlus
S455 Phosphorylation PhosphoSitePlus
S514 Phosphorylation PhosphoSitePlus
S517 Phosphorylation PhosphoSitePlus
T524 Phosphorylation PhosphoSitePlus
S528 Phosphorylation PhosphoSitePlus   UniProt 18691976, 23186163, 20068231, ...19369195
S542 Phosphorylation PhosphoSitePlus
S543 Phosphorylation PhosphoSitePlus
S546 Phosphorylation PhosphoSitePlus
S561 Phosphorylation PhosphoSitePlus
T592 Phosphorylation PhosphoSitePlus   UniProt 19369195
S597 Phosphorylation PhosphoSitePlus
T604 Phosphorylation PhosphoSitePlus
S614 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 19369195, 18669648, 23186163
S618 Phosphorylation PhosphoSitePlus
S621 Phosphorylation PhosphoSitePlus
T622 Phosphorylation PhosphoSitePlus
S650 Phosphorylation PhosphoSitePlus
Y669 Phosphorylation PhosphoSitePlus
T719 Phosphorylation PhosphoSitePlus
Y724 Phosphorylation PhosphoSitePlus
S768 Phosphorylation PhosphoSitePlus
S773 Phosphorylation PhosphoSitePlus
S895 Phosphorylation PhosphoSitePlus
S920 Phosphorylation PhosphoSitePlus
S932 Phosphorylation PhosphoSitePlus
S949 Phosphorylation PhosphoSitePlus
S1026 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S514 Phosphorylation HPRD 18691976
S528 Phosphorylation HPRD 19413330, 18691976, 19664994, ...20068231
S543 Phosphorylation HPRD 19413330
S546 Phosphorylation HPRD 19413330
S614 Phosphorylation HPRD 18691976, 18669648
Site PTM Type PTM Enzyme Score Source PMID
S562 Phosphorylation PhosphoSitePlus


Q5TCX8 (MAP3K21) as PTM Enzyme



Substrate Site Score Source PMID
Q02750 (MAP2K1) S218 neXtProt   Signor 23319808
Q02750 (MAP2K1) S222 neXtProt   Signor 23319808


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S111 L111 Biomuta DOID:4606 / bile duct cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
S111 W111 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
T142 I142 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K286 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S514 I514 Biomuta DOID:9256 / colorectal cancer [ icgc ]
T524 I524 Biomuta [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
S542 F542 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S543 I543 Biomuta DOID:1324 / lung cancer [ cosmic ]
S614 F614 Biomuta DOID:4159 / skin cancer [ cosmic ]
S618 N618 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S650 F650 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y724 * Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S949 F949 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1026 F1026 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1026 C1026 Biomuta DOID:4159 / skin cancer [ cosmic ]