iPTMnet Report for Q5TC82 (RC3H1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q5TC82 / RC3H1_HUMAN
Protein Name Roquin-1
Gene Name Name: RC3H1
Synonyms:KIAA2025,RNF198;
Organism Homo sapiens (Human)

PRO ID PR:Q5TC82
DAG View
PRO Name roquin-1 (human)
Definition A roquin-1 that is encoded in the genome of human.
Short Label hRC3H1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q5TC82 (RC3H1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S115 Phosphorylation PhosphoSitePlus
S127 Phosphorylation PhosphoSitePlus
S130 Phosphorylation PhosphoSitePlus
S253 Phosphorylation PhosphoSitePlus
T326 Phosphorylation PhosphoSitePlus
S460 Phosphorylation PhosphoSitePlus
S462 Phosphorylation PhosphoSitePlus   UniProt 24275569
S529 Phosphorylation PhosphoSitePlus
S530 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S531 Phosphorylation PhosphoSitePlus
S535 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
Y592 Phosphorylation PhosphoSitePlus
Y593 Phosphorylation PhosphoSitePlus
R597 Methylation PhosphoSitePlus
R623 Methylation PhosphoSitePlus
Y662 Phosphorylation PhosphoSitePlus
S690 Phosphorylation IEDB 35494241
S717 Phosphorylation PhosphoSitePlus
Y718 Phosphorylation PhosphoSitePlus
R729 Methylation PhosphoSitePlus
R734 Methylation PhosphoSitePlus
R740 Methylation PhosphoSitePlus
S772 Phosphorylation PhosphoSitePlus
S779 Phosphorylation PhosphoSitePlus
T781 Phosphorylation PhosphoSitePlus
S808 Phosphorylation PhosphoSitePlus
Y810 Phosphorylation PhosphoSitePlus
S811 Phosphorylation PhosphoSitePlus
S863 Phosphorylation PhosphoSitePlus   UniProt 23186163
S877 O-Glycosylation GlyGen 31492838, 30620550
S953 Phosphorylation PhosphoSitePlus
T1040 Phosphorylation PhosphoSitePlus
S1044 Phosphorylation PhosphoSitePlus
S1131 O-Glycosylation GlyGen 31492838, 30620550
Site PTM Type PTM Enzyme Score Source PMID
S253 Phosphorylation HPRD 19413330
S530 Phosphorylation HPRD 18669648
S535 Phosphorylation HPRD 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S529 N529 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S530 I530 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S531 G531 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R623 L623 Biomuta DOID:1324 / lung cancer [ cosmic ]
R623 C623 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y662 F662 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S717 N717 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R740 Q740 Biomuta DOID:363 / uterine cancer [ cosmic ]
R740 W740 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S772 C772 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S772 F772 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y810 H810 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]