iPTMnet Report for Q5TBB1 (RNASEH2B)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q5TBB1 / RNH2B_HUMAN
Protein Name Ribonuclease H2 subunit B
Gene Name Name: RNASEH2B
Synonyms:DLEU8;
Organism Homo sapiens (Human)

PRO ID PR:Q5TBB1
DAG View
PRO Name ribonuclease H2 subunit B (human)
Definition A ribonuclease H2 subunit B that is encoded in the genome of human.
Short Label hRNASEH2B
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q5TBB1 (RNASEH2B) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22814378, 22223895
K25 Ubiquitination PhosphoSitePlus
K136 Ubiquitination PhosphoSitePlus
K145 Ubiquitination PhosphoSitePlus
K165 Ubiquitination PhosphoSitePlus
K170 Ubiquitination PhosphoSitePlus
T174 Phosphorylation PhosphoSitePlus
K179 Ubiquitination PhosphoSitePlus
S191 Phosphorylation PhosphoSitePlus
K204 Ubiquitination PhosphoSitePlus
K222 Ubiquitination PhosphoSitePlus
K230 Ubiquitination PhosphoSitePlus
K233 Ubiquitination PhosphoSitePlus
S240 Phosphorylation PhosphoSitePlus
S246 Phosphorylation PhosphoSitePlus
K247 Acetylation PhosphoSitePlus
K250 Sumoylation PhosphoSitePlus
K250 Ubiquitination PhosphoSitePlus
S252 Phosphorylation PhosphoSitePlus
K259 Sumoylation PhosphoSitePlus
K259 Ubiquitination PhosphoSitePlus
Y262 Phosphorylation PhosphoSitePlus
T263 Phosphorylation PhosphoSitePlus
K264 Acetylation PhosphoSitePlus
K264 Ubiquitination PhosphoSitePlus
T267 Phosphorylation PhosphoSitePlus
K278 Acetylation PhosphoSitePlus
K284 Ubiquitination PhosphoSitePlus
K295 Acetylation PhosphoSitePlus   UniProt 19608861
K295 Ubiquitination PhosphoSitePlus
S296 Phosphorylation PhosphoSitePlus   UniProt 23186163
T299 Phosphorylation PhosphoSitePlus
K304 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K233 N233 Biomuta DOID:1324 / lung cancer [ cosmic ]
S246 L246 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
K259 N259 Biomuta DOID:3571 / liver cancer [ cosmic ]
T263 A263 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K284 R284 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]