iPTMnet Report for Q5TB30 (DEPDC1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q5TB30 / DEP1A_HUMAN
Protein Name DEP domain-containing protein 1A
Gene Name Name: DEPDC1
Synonyms:DEPDC1A;
Organism Homo sapiens (Human)

PRO ID PR:Q5TB30
DAG View
PRO Name DEP domain-containing protein 1A (human)
Definition A DEP domain-containing protein 1A that is encoded in the genome of human.
Short Label hDEPDC1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q5TB30 (DEPDC1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K89 Ubiquitination PhosphoSitePlus
T109 Phosphorylation PhosphoSitePlus
S110 Phosphorylation PhosphoSitePlus   RLIMS-P 28602627
K113 Ubiquitination PhosphoSitePlus
K124 Ubiquitination PhosphoSitePlus
K134 Ubiquitination PhosphoSitePlus
S240 Phosphorylation PhosphoSitePlus
S249 Phosphorylation PhosphoSitePlus
K320 Ubiquitination PhosphoSitePlus
K329 Ubiquitination PhosphoSitePlus
S338 Phosphorylation PhosphoSitePlus
S341 Phosphorylation PhosphoSitePlus
S348 Phosphorylation PhosphoSitePlus
K356 Acetylation PhosphoSitePlus
S361 Phosphorylation PhosphoSitePlus
S391 Phosphorylation PhosphoSitePlus
S422 Phosphorylation PhosphoSitePlus
S444 Phosphorylation PhosphoSitePlus
S471 Phosphorylation PhosphoSitePlus
K484 Methylation PhosphoSitePlus
S510 O-Glycosylation GlyGen 30379171
S512 O-Glycosylation GlyGen 30379171
S512 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S523 Phosphorylation PhosphoSitePlus
S625 Phosphorylation PhosphoSitePlus
S644 O-Glycosylation GlyGen 30379171, 35254053
T649 O-Glycosylation GlyGen 30379171, 35254053
K701 Ubiquitination PhosphoSitePlus
K723 Ubiquitination PhosphoSitePlus
K769 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T109 Phosphorylation HPRD 19664995


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K89 E89 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S110 L110 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
K134 * Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
S338 F338 Biomuta DOID:4159 / skin cancer [ cosmic ]
S341 T341 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S348 I348 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S361 Y361 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S471 L471 Biomuta DOID:4159 / skin cancer [ cosmic, icgc, tcga ]
K484 * Biomuta DOID:4159 / skin cancer [ cosmic ]
S625 F625 Biomuta DOID:4159 / skin cancer [ cosmic ]
S625 A625 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
S644 * Biomuta DOID:363 / uterine cancer [ cosmic ]
K769 M769 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]