iPTMnet Report for Q5T5U3 (ARHGAP21)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q5T5U3 / RHG21_HUMAN
Protein Name Rho GTPase-activating protein 21
Gene Name Name: ARHGAP21
Synonyms:ARHGAP10,KIAA1424;
Organism Homo sapiens (Human)

PRO ID PR:Q5T5U3
DAG View
PRO Name Rho GTPase-activating protein 21 (human)
Definition A Rho GTPase-activating protein 21 that is encoded in the genome of human.
Short Label hARHGAP21
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q5T5U3 (ARHGAP21) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S10 Phosphorylation PhosphoSitePlus
K26 Acetylation PhosphoSitePlus
K29 Acetylation PhosphoSitePlus
K49 Acetylation PhosphoSitePlus
S57 Phosphorylation PhosphoSitePlus   UniProt 20068231
T63 Phosphorylation PhosphoSitePlus
S131 Phosphorylation PhosphoSitePlus
T232 Phosphorylation PhosphoSitePlus
S233 Phosphorylation PhosphoSitePlus
T234 Phosphorylation PhosphoSitePlus
Y244 Phosphorylation PhosphoSitePlus
S253 Phosphorylation PhosphoSitePlus
T255 Phosphorylation PhosphoSitePlus
S286 Phosphorylation PhosphoSitePlus
S319 Phosphorylation PhosphoSitePlus
S338 Phosphorylation PhosphoSitePlus
K347 Methylation PhosphoSitePlus
K347 Ubiquitination PhosphoSitePlus
Y351 Phosphorylation PhosphoSitePlus
S352 Phosphorylation PhosphoSitePlus
S377 Phosphorylation PhosphoSitePlus
Y392 Phosphorylation PhosphoSitePlus
Y395 Phosphorylation PhosphoSitePlus
T423 Phosphorylation PhosphoSitePlus
Y425 Phosphorylation PhosphoSitePlus
S441 Phosphorylation PhosphoSitePlus
T442 Phosphorylation PhosphoSitePlus
S443 Phosphorylation PhosphoSitePlus
S457 Phosphorylation PhosphoSitePlus
S459 Phosphorylation PhosphoSitePlus   UniProt 18669648
Y471 Phosphorylation PhosphoSitePlus
S475 O-Glycosylation GlyGen 30379171, 32938750, 30059200, ...35254053, 31492838, 29237092
S475 Phosphorylation PhosphoSitePlus
S477 Phosphorylation PhosphoSitePlus
T482 Phosphorylation PhosphoSitePlus
S483 Phosphorylation PhosphoSitePlus
S485 Phosphorylation PhosphoSitePlus
S487 Phosphorylation PhosphoSitePlus
S489 Phosphorylation PhosphoSitePlus
T493 Phosphorylation PhosphoSitePlus
S552 Phosphorylation PhosphoSitePlus
R554 Methylation PhosphoSitePlus   UniProt 24129315
S563 Phosphorylation PhosphoSitePlus
R575 Methylation PhosphoSitePlus   UniProt 24129315
S606 Phosphorylation PhosphoSitePlus
R609 Methylation PhosphoSitePlus
S612 Phosphorylation PhosphoSitePlus   UniProt 23186163
S616 Phosphorylation PhosphoSitePlus   UniProt 23186163
S625 Phosphorylation PhosphoSitePlus   UniProt 23186163
K627 Acetylation PhosphoSitePlus
S659 Phosphorylation PhosphoSitePlus
S671 Phosphorylation PhosphoSitePlus
K681 Ubiquitination PhosphoSitePlus
S682 Phosphorylation PhosphoSitePlus
S684 Phosphorylation PhosphoSitePlus
S717 Phosphorylation PhosphoSitePlus   UniProt 20068231
S743 Phosphorylation PhosphoSitePlus
T747 Phosphorylation PhosphoSitePlus   UniProt 23186163
S755 Phosphorylation PhosphoSitePlus
S857 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
S862 Phosphorylation PhosphoSitePlus
S867 Phosphorylation PhosphoSitePlus
S879 Phosphorylation PhosphoSitePlus
S881 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y882 Phosphorylation PhosphoSitePlus   UniProt 24275569
Y889 Phosphorylation PhosphoSitePlus
S896 Phosphorylation PhosphoSitePlus
K898 Methylation PhosphoSitePlus
K904 Ubiquitination PhosphoSitePlus
S911 Phosphorylation PhosphoSitePlus
S918 Phosphorylation PhosphoSitePlus
S924 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163
S925 Phosphorylation PhosphoSitePlus
S926 Phosphorylation PhosphoSitePlus
S930 Phosphorylation PhosphoSitePlus
S954 Phosphorylation PhosphoSitePlus   UniProt 23186163
T980 Phosphorylation PhosphoSitePlus
S983 Phosphorylation PhosphoSitePlus
K1059 Methylation PhosphoSitePlus
T1074 Phosphorylation PhosphoSitePlus
S1078 Phosphorylation PhosphoSitePlus
S1080 Phosphorylation PhosphoSitePlus
S1096 Phosphorylation PhosphoSitePlus
S1099 Phosphorylation PhosphoSitePlus
S1104 Phosphorylation PhosphoSitePlus
S1115 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1129 Phosphorylation PhosphoSitePlus
T1134 Phosphorylation PhosphoSitePlus
T1140 Phosphorylation PhosphoSitePlus
T1142 Phosphorylation PhosphoSitePlus
T1144 Phosphorylation PhosphoSitePlus
S1220 Phosphorylation phospho.ELM 17081983
K1239 Ubiquitination PhosphoSitePlus
Y1240 Phosphorylation PhosphoSitePlus
T1375 Phosphorylation PhosphoSitePlus
S1378 Phosphorylation PhosphoSitePlus
S1383 Phosphorylation PhosphoSitePlus
K1392 Ubiquitination PhosphoSitePlus
S1396 Phosphorylation PhosphoSitePlus
Y1404 Phosphorylation PhosphoSitePlus
S1412 Phosphorylation PhosphoSitePlus
S1418 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1431 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1432 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S1433 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
K1443 Sumoylation PhosphoSitePlus
S1492 Phosphorylation PhosphoSitePlus
S1497 Phosphorylation PhosphoSitePlus
T1498 Phosphorylation PhosphoSitePlus
S1504 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1509 Phosphorylation PhosphoSitePlus
S1514 Phosphorylation PhosphoSitePlus
T1516 Phosphorylation PhosphoSitePlus   UniProt 24275569
S1518 Phosphorylation PhosphoSitePlus
S1527 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
S1530 Phosphorylation PhosphoSitePlus
S1562 Phosphorylation PhosphoSitePlus
S1566 Phosphorylation PhosphoSitePlus
S1605 Phosphorylation PhosphoSitePlus
S1624 Phosphorylation PhosphoSitePlus
S1628 Phosphorylation PhosphoSitePlus
T1635 Phosphorylation PhosphoSitePlus
S1637 Phosphorylation PhosphoSitePlus
S1639 Phosphorylation PhosphoSitePlus
S1669 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163
S1672 Phosphorylation PhosphoSitePlus
S1675 Phosphorylation PhosphoSitePlus
S1680 Phosphorylation PhosphoSitePlus
S1684 Phosphorylation PhosphoSitePlus
S1687 Phosphorylation PhosphoSitePlus
T1702 Phosphorylation PhosphoSitePlus
S1708 Phosphorylation PhosphoSitePlus
S1713 Phosphorylation PhosphoSitePlus
S1717 Phosphorylation PhosphoSitePlus
S1742 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1745 Phosphorylation IEDB   PhosphoSitePlus 35494241
T1748 Phosphorylation PhosphoSitePlus
K1762 Methylation PhosphoSitePlus
K1764 Methylation PhosphoSitePlus
S1797 Phosphorylation PhosphoSitePlus
T1803 Phosphorylation PhosphoSitePlus
S1843 Phosphorylation PhosphoSitePlus
T1860 Phosphorylation PhosphoSitePlus
S1861 Phosphorylation PhosphoSitePlus
T1862 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S57 Phosphorylation HPRD 20068231
S286 Phosphorylation HPRD 20068231
T317 Phosphorylation HPRD 20068231
S319 Phosphorylation HPRD 18767875
S380 Phosphorylation HPRD 20068231
S459 Phosphorylation HPRD 18669648
S475 Phosphorylation HPRD 18669648
S483 Phosphorylation HPRD 18669648
S616 Phosphorylation HPRD 19691289, 20068231
S717 Phosphorylation HPRD 20068231
S857 Phosphorylation HPRD 18669648, 17081983, 20068231
S867 Phosphorylation HPRD 20068231
S874 Phosphorylation HPRD 17081983
S881 Phosphorylation HPRD 19651622, 20068231
S924 Phosphorylation HPRD 18767875, 18669648, 18212344, ...19691289
S925 Phosphorylation HPRD 17081983
S954 Phosphorylation HPRD 18212344
T1074 Phosphorylation HPRD 19413330
S1090 Phosphorylation HPRD 17081983
S1221 Phosphorylation HPRD 17081983
Y1240 Phosphorylation HPRD 18669648
T1283 Phosphorylation HPRD 17081983
S1378 Phosphorylation HPRD 18669648
S1383 Phosphorylation HPRD 19413330, 18669648
S1431 Phosphorylation HPRD 18669648, 20068231, 18452278
S1432 Phosphorylation HPRD 18669648, 20068231, 18452278
S1433 Phosphorylation HPRD 19413330, 18669648, 19664994, ...20068231, 18452278
T1516 Phosphorylation HPRD 20068231
S1527 Phosphorylation HPRD 18669648, 20068231
S1605 Phosphorylation HPRD 19664994, 19691289
T1635 Phosphorylation HPRD 18669648, 17081983
S1637 Phosphorylation HPRD 18669648, 17081983
S1639 Phosphorylation HPRD 18669648, 17081983
S1669 Phosphorylation HPRD 18669648
S1672 Phosphorylation HPRD 18669648
T1743 Phosphorylation HPRD 20068231
T1750 Phosphorylation HPRD 20068231
T1860 Phosphorylation HPRD 20068231
S1861 Phosphorylation HPRD 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T232 S232 Biomuta DOID:2531 / hematologic cancer [ cosmic, icgc ]
S233 I233 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S380 F380 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y392 C392 Biomuta DOID:363 / uterine cancer [ icgc ]
S443 P443 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S552 Y552 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R554 * Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
R554 Q554 Biomuta DOID:363 / uterine cancer [ icgc ]
R554 P554 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
R609 Q609 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ]
S625 Y625 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S874 L874 Biomuta DOID:1324 / lung cancer [ cosmic ]
S879 * Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S896 F896 Biomuta DOID:363 / uterine cancer [ icgc ]
K904 E904 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
K904 N904 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S924 Y924 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S924 F924 Biomuta DOID:4159 / skin cancer [ cosmic ]
S926 L926 Biomuta DOID:1324 / lung cancer [ cosmic ]
T980 R980 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
K1059 T1059 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1080 I1080 Biomuta DOID:1319 / brain cancer [ cosmic ]
S1090 L1090 Biomuta DOID:3571 / liver cancer [ cosmic ]
S1096 R1096 Biomuta DOID:3571 / liver cancer [ cosmic ]
S1104 L1104 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1115 I1115 Biomuta DOID:184 / bone cancer [ cosmic ]
T1283 I1283 Biomuta DOID:1319 / brain cancer [ cosmic ]
S1383 L1383 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1432 N1432 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
K1443 N1443 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1492 L1492 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1509 T1509 Biomuta DOID:263 / kidney cancer [ cosmic ]
S1509 * Biomuta DOID:4159 / skin cancer [ cosmic ]
S1637 N1637 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1639 N1639 Biomuta DOID:184 / bone cancer [ cosmic ]
S1669 Y1669 Biomuta DOID:363 / uterine cancer [ icgc ]
T1702 A1702 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K1762 T1762 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]