Protein Information

Cytoscape View


UniProt AC / UniProt ID Q5T4S7 / UBR4_HUMAN
Protein Name E3 ubiquitin-protein ligase UBR4
Gene Name Name: UBR4
Synonyms:KIAA0462,KIAA1307,RBAF600,ZUBR1;
Organism Homo sapiens (Human)

PRO ID PR:Q5T4S7
DAG View
PRO Name E3 ubiquitin-protein ligase UBR4 (human)
Definition An E3 ubiquitin-protein ligase UBR4 that is encoded in the genome of human.
Short Label hUBR4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q5T4S7 (UBR4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T18 Phosphorylation PhosphoSitePlus
S59 Phosphorylation PhosphoSitePlus
S61 Phosphorylation PhosphoSitePlus
S99 O-Glycosylation GlyGen 23301498, 29351928
S111 Phosphorylation PhosphoSitePlus
K127 Ubiquitination PhosphoSitePlus
K159 Ubiquitination PhosphoSitePlus
K165 Ubiquitination PhosphoSitePlus
K174 Ubiquitination PhosphoSitePlus
S178 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S181 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332, ...20068231
K187 Ubiquitination PhosphoSitePlus
K234 Ubiquitination PhosphoSitePlus
K236 Ubiquitination PhosphoSitePlus
K255 Ubiquitination PhosphoSitePlus
T360 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S362 Phosphorylation PhosphoSitePlus
T363 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S364 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S365 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K366 Ubiquitination PhosphoSitePlus
Y370 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S372 Phosphorylation PhosphoSitePlus
T376 Phosphorylation PhosphoSitePlus
Y385 Phosphorylation PhosphoSitePlus
K436 Ubiquitination PhosphoSitePlus
S457 Phosphorylation PhosphoSitePlus
K459 Ubiquitination PhosphoSitePlus
T485 Phosphorylation PhosphoSitePlus
S486 Phosphorylation PhosphoSitePlus
S555 Phosphorylation PhosphoSitePlus
S557 Phosphorylation PhosphoSitePlus
K605 Ubiquitination PhosphoSitePlus
S619 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S620 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S625 Phosphorylation PhosphoSitePlus
S627 Phosphorylation PhosphoSitePlus
K634 Ubiquitination PhosphoSitePlus
S665 Phosphorylation PhosphoSitePlus
K781 Ubiquitination PhosphoSitePlus
T904 Phosphorylation PhosphoSitePlus
T905 Phosphorylation PhosphoSitePlus   UniProt 23186163
K920 Ubiquitination PhosphoSitePlus
Y963 Phosphorylation PhosphoSitePlus
Y1001 Phosphorylation PhosphoSitePlus
Y1002 Phosphorylation PhosphoSitePlus
K1060 Ubiquitination PhosphoSitePlus
K1064 Ubiquitination PhosphoSitePlus
K1079 Ubiquitination PhosphoSitePlus
K1084 Acetylation PhosphoSitePlus   UniProt 19608861
K1084 Ubiquitination PhosphoSitePlus
K1141 Ubiquitination PhosphoSitePlus
K1150 Ubiquitination PhosphoSitePlus
K1156 Ubiquitination PhosphoSitePlus
K1189 Ubiquitination PhosphoSitePlus
S1343 O-Glycosylation GlyGen 23301498, 29351928
K1477 Ubiquitination PhosphoSitePlus
K1574 Ubiquitination PhosphoSitePlus
K1579 Ubiquitination PhosphoSitePlus
S1634 Phosphorylation PhosphoSitePlus
S1647 Phosphorylation PhosphoSitePlus   UniProt 24275569
S1652 Phosphorylation PhosphoSitePlus   UniProt 24275569
K1729 Ubiquitination PhosphoSitePlus
T1731 Phosphorylation PhosphoSitePlus
S1733 Phosphorylation PhosphoSitePlus
T1739 Phosphorylation PhosphoSitePlus
K1741 Ubiquitination PhosphoSitePlus
S1747 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1752 Phosphorylation PhosphoSitePlus
S1754 Phosphorylation PhosphoSitePlus
S1760 Phosphorylation PhosphoSitePlus
T1761 Phosphorylation PhosphoSitePlus
S1762 Phosphorylation PhosphoSitePlus
S1763 Phosphorylation PhosphoSitePlus   UniProt 20068231
K1769 Ubiquitination PhosphoSitePlus
S1773 Phosphorylation PhosphoSitePlus
K1776 Ubiquitination PhosphoSitePlus
S1878 Phosphorylation PhosphoSitePlus   UniProt 23186163
T1884 Phosphorylation PhosphoSitePlus
S1904 Phosphorylation PhosphoSitePlus   UniProt 23186163
K1931 Acetylation PhosphoSitePlus
K1931 Ubiquitination PhosphoSitePlus
K1939 Ubiquitination PhosphoSitePlus
T1941 Phosphorylation PhosphoSitePlus
T1943 Phosphorylation PhosphoSitePlus
S1947 Phosphorylation PhosphoSitePlus
T1958 Phosphorylation PhosphoSitePlus
Y2087 Phosphorylation PhosphoSitePlus
S2131 Phosphorylation PhosphoSitePlus
T2140 Phosphorylation PhosphoSitePlus
T2196 Phosphorylation PhosphoSitePlus
T2204 Phosphorylation PhosphoSitePlus
K2210 Ubiquitination PhosphoSitePlus
R2227 Methylation PhosphoSitePlus
Y2242 Phosphorylation PhosphoSitePlus
K2273 Ubiquitination PhosphoSitePlus
K2502 Ubiquitination PhosphoSitePlus
Y2539 Phosphorylation PhosphoSitePlus
S2541 Phosphorylation PhosphoSitePlus
K2543 Ubiquitination PhosphoSitePlus
S2549 Phosphorylation PhosphoSitePlus
K2550 Ubiquitination PhosphoSitePlus
K2560 Ubiquitination PhosphoSitePlus
K2563 Ubiquitination PhosphoSitePlus
K2698 Ubiquitination PhosphoSitePlus
T2715 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S2718 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S2719 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692, 23186163, ...17081983
S2722 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 17081983
T2724 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 17081983
S2743 Phosphorylation PhosphoSitePlus
S2756 Phosphorylation PhosphoSitePlus
T2884 Phosphorylation PhosphoSitePlus
S2885 Phosphorylation PhosphoSitePlus
S2892 Phosphorylation PhosphoSitePlus
S2895 Phosphorylation PhosphoSitePlus
S2897 Phosphorylation PhosphoSitePlus
S2900 Phosphorylation PhosphoSitePlus
S2910 Phosphorylation PhosphoSitePlus
Y2918 Phosphorylation PhosphoSitePlus
S2932 Phosphorylation P42345 (MTOR) PhosphoSitePlus 21659604
S2934 Phosphorylation PhosphoSitePlus
T2937 Phosphorylation PhosphoSitePlus
T2942 Phosphorylation PhosphoSitePlus
T2943 Phosphorylation PhosphoSitePlus
T2944 Phosphorylation PhosphoSitePlus   UniProt 24275569
S2952 Phosphorylation PhosphoSitePlus   UniProt 24275569
T2960 Phosphorylation PhosphoSitePlus
K3126 Ubiquitination PhosphoSitePlus
S3132 Phosphorylation PhosphoSitePlus
Y3169 Phosphorylation PhosphoSitePlus
T3175 Phosphorylation PhosphoSitePlus
T3177 Phosphorylation PhosphoSitePlus
S3179 Phosphorylation PhosphoSitePlus
S3220 Phosphorylation PhosphoSitePlus
K3292 Ubiquitination PhosphoSitePlus
S3339 Phosphorylation PhosphoSitePlus
S3346 Phosphorylation PhosphoSitePlus
S3347 Phosphorylation PhosphoSitePlus
S3349 Phosphorylation PhosphoSitePlus
T3361 Phosphorylation PhosphoSitePlus
S3366 Phosphorylation PhosphoSitePlus
T3367 Phosphorylation PhosphoSitePlus
K3379 Ubiquitination PhosphoSitePlus
S3386 Phosphorylation PhosphoSitePlus
K3401 Ubiquitination PhosphoSitePlus
K3405 Ubiquitination PhosphoSitePlus
K3464 Ubiquitination PhosphoSitePlus
K3485 Ubiquitination PhosphoSitePlus
K3487 Ubiquitination PhosphoSitePlus
K3551 Ubiquitination PhosphoSitePlus
K3573 Ubiquitination PhosphoSitePlus
K3577 Ubiquitination PhosphoSitePlus
K3617 Ubiquitination PhosphoSitePlus
K3745 Ubiquitination PhosphoSitePlus
K3774 Ubiquitination PhosphoSitePlus
K3808 Ubiquitination PhosphoSitePlus
K3816 Ubiquitination PhosphoSitePlus
K3820 Ubiquitination PhosphoSitePlus
K3826 Ubiquitination PhosphoSitePlus
S3842 Phosphorylation PhosphoSitePlus
S3854 Phosphorylation PhosphoSitePlus
S3860 Phosphorylation PhosphoSitePlus
T3892 Phosphorylation PhosphoSitePlus
T4005 Phosphorylation PhosphoSitePlus
T4013 Phosphorylation PhosphoSitePlus
K4035 Ubiquitination PhosphoSitePlus
K4065 Ubiquitination PhosphoSitePlus
Y4068 Phosphorylation PhosphoSitePlus
K4072 Ubiquitination PhosphoSitePlus
R4078 Methylation PhosphoSitePlus
K4089 Ubiquitination PhosphoSitePlus
K4100 Ubiquitination PhosphoSitePlus
K4106 Ubiquitination PhosphoSitePlus
S4117 Phosphorylation PhosphoSitePlus
K4122 Ubiquitination PhosphoSitePlus
R4158 Methylation PhosphoSitePlus
K4215 Ubiquitination PhosphoSitePlus
T4300 Phosphorylation PhosphoSitePlus
T4316 Phosphorylation PhosphoSitePlus
Y4325 Phosphorylation PhosphoSitePlus
S4416 Phosphorylation PhosphoSitePlus
K4427 Ubiquitination PhosphoSitePlus
R4491 Methylation PhosphoSitePlus
R4496 Methylation PhosphoSitePlus
K4685 Ubiquitination PhosphoSitePlus
K4696 Ubiquitination PhosphoSitePlus
K4703 Ubiquitination PhosphoSitePlus
K4711 Ubiquitination PhosphoSitePlus
K4712 Ubiquitination PhosphoSitePlus
S4755 Phosphorylation PhosphoSitePlus
T4762 Phosphorylation PhosphoSitePlus
K4802 Ubiquitination PhosphoSitePlus
K4814 Ubiquitination PhosphoSitePlus
T4819 Phosphorylation PhosphoSitePlus
K4820 Ubiquitination PhosphoSitePlus
K4846 Acetylation PhosphoSitePlus
K4860 Ubiquitination PhosphoSitePlus
S4973 Phosphorylation PhosphoSitePlus
S4975 Phosphorylation PhosphoSitePlus
T4978 Phosphorylation PhosphoSitePlus
K5022 Ubiquitination PhosphoSitePlus
Y5135 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S178 Phosphorylation HPRD 19413330, 19651622, 18669648, ...19664994, 20068231
S181 Phosphorylation HPRD 19413330, 18767875, 19664994, ...19651622, 18669648, 20068231
T360 Phosphorylation HPRD 18669648
T363 Phosphorylation HPRD 18669648, 18452278
S364 Phosphorylation HPRD 18669648
S365 Phosphorylation HPRD 18669648
Y370 Phosphorylation HPRD 18669648
S619 Phosphorylation HPRD 18691976, 18669648, 19415658, ...20068231, 19664995
S620 Phosphorylation HPRD 19413330, 17081983, 19664994, ...19664995, 19651622, 18669648, 19415658, 20068231
S625 Phosphorylation HPRD 20068231
T1077 Phosphorylation HPRD 20068231
T1078 Phosphorylation HPRD 20068231
S1760 Phosphorylation HPRD 19651622, 20068231
T1761 Phosphorylation HPRD 17081983, 20068231
S1762 Phosphorylation HPRD 19651622, 17081983
S1763 Phosphorylation HPRD 19651622, 17081983, 20068231
S1927 Phosphorylation HPRD 20068231
T2278 Phosphorylation HPRD 17081983
T2279 Phosphorylation HPRD 17081983
T2715 Phosphorylation HPRD 19651622, 18669648, 20068231
S2718 Phosphorylation HPRD 18691976, 17081983, 19651622, ...18669648, 19415658, 20068231, 17924679
S2719 Phosphorylation HPRD 19651622, 20166139, 18669648, ...17081983, 20068231
S2722 Phosphorylation HPRD 19651622, 18669648, 17081983
T2724 Phosphorylation HPRD 19651622, 18669648, 17081983
T2884 Phosphorylation HPRD 20166139, 18452278
T3175 Phosphorylation HPRD 20068231
T3177 Phosphorylation HPRD 20068231
S3179 Phosphorylation HPRD 20068231
T3432 Phosphorylation HPRD 18691976
Y4270 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S1760 Phosphorylation PhosphoSitePlus
T1761 Phosphorylation PhosphoSitePlus
S1762 Phosphorylation PhosphoSitePlus
S1763 Phosphorylation PhosphoSitePlus
T2468 Phosphorylation PhosphoSitePlus
T2470 Phosphorylation PhosphoSitePlus
T2473 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S61 L61 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
S111 Y111 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
S178 * Biomuta DOID:3571 / liver cancer [ icgc ]
S365 P365 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
Y370 C370 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K605 * Biomuta DOID:263 / kidney cancer [ cosmic ]
K920 T920 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
K1156 N1156 Biomuta DOID:363 / uterine cancer [ tcga ]
S1343 Y1343 Biomuta DOID:3070 / malignant glioma [ cosmic ]
K1574 N1574 Biomuta DOID:263 / kidney cancer [ cosmic, icgc, tcga ]
S1634 P1634 Biomuta DOID:1793 / pancreatic cancer [ tcga ]
T1731 N1731 Biomuta DOID:3571 / liver cancer [ icgc ]
S1760 G1760 Biomuta DOID:1324 / lung cancer [ cosmic ]
K1776 N1776 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:363 / uterine cancer [ tcga ]
S1904 C1904 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc, tcga ]
T1943 N1943 Biomuta DOID:3571 / liver cancer [ icgc ]
T2140 N2140 Biomuta DOID:1324 / lung cancer [ tcga ]
T2204 I2204 Biomuta DOID:1324 / lung cancer [ cosmic ]
R2227 W2227 Biomuta DOID:363 / uterine cancer [ tcga ]
K2502 N2502 Biomuta DOID:363 / uterine cancer [ tcga ]
Y2539 C2539 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
T2715 A2715 Biomuta DOID:3277 / thymus cancer [ tcga ]
T2715 P2715 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
S2897 R2897 Biomuta DOID:1324 / lung cancer [ cosmic ]
S2910 N2910 Biomuta DOID:9256 / colorectal cancer [ tcga ]
S3347 F3347 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
T3432 K3432 Biomuta DOID:3571 / liver cancer [ icgc ]
K3774 T3774 Biomuta DOID:5041 / esophageal cancer [ icgc ]
T3892 P3892 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
T4013 I4013 Biomuta DOID:363 / uterine cancer [ tcga ]
R4158 C4158 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
R4496 K4496 Biomuta DOID:2531 / hematologic cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K4703 M4703 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
K4712 T4712 Biomuta DOID:1909 / melanoma [ cosmic ]