iPTMnet Report for Q5T447 (HECTD3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q5T447 / HECD3_HUMAN
Protein Name E3 ubiquitin-protein ligase HECTD3
Gene Name Name: HECTD3
Organism Homo sapiens (Human)

PRO ID PR:Q5T447
DAG View
PRO Name E3 ubiquitin-protein ligase HECTD3 (human)
Definition An E3 ubiquitin-protein ligase HECTD3 that is encoded in the genome of human.
Short Label hHECTD3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q5T447 (HECTD3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22814378, 22223895
S12 Phosphorylation PhosphoSitePlus   UniProt 23186163
K50 Ubiquitination PhosphoSitePlus
K53 Ubiquitination PhosphoSitePlus
S59 Phosphorylation PhosphoSitePlus
T84 Phosphorylation PhosphoSitePlus
S95 Phosphorylation PhosphoSitePlus
C133 Methylation IEDB 31844290
T157 Phosphorylation PhosphoSitePlus   RLIMS-P 28716524
S192 Phosphorylation PhosphoSitePlus
K308 Ubiquitination PhosphoSitePlus
K321 Ubiquitination PhosphoSitePlus
Y393 Phosphorylation PhosphoSitePlus
S449 Phosphorylation IEDB 35494241
K467 Ubiquitination PhosphoSitePlus
K507 Ubiquitination PhosphoSitePlus
K511 Ubiquitination PhosphoSitePlus
Y586 Phosphorylation PhosphoSitePlus
K636 Ubiquitination PhosphoSitePlus
S643 Phosphorylation PhosphoSitePlus
K663 Ubiquitination PhosphoSitePlus
K705 Ubiquitination PhosphoSitePlus
K712 Ubiquitination PhosphoSitePlus
K742 Ubiquitination PhosphoSitePlus
K808 Ubiquitination PhosphoSitePlus
K841 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S192 L192 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K636 N636 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K663 M663 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]