iPTMnet Report for Q5T200 (ZC3H13)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q5T200 / ZC3HD_HUMAN
Protein Name Zinc finger CCCH domain-containing protein 13
Gene Name Name: ZC3H13
Synonyms:KIAA0853;
Organism Homo sapiens (Human)

PRO ID PR:Q5T200
DAG View
PRO Name zinc finger CCCH domain-containing protein 13 (human)
Definition A zinc finger CCCH domain-containing protein 13 that is encoded in the genome of human.
Short Label hZC3H13
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q5T200 (ZC3H13) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T9 Phosphorylation PhosphoSitePlus
S17 Phosphorylation PhosphoSitePlus
S25 Phosphorylation PhosphoSitePlus
K47 Methylation PhosphoSitePlus
Y53 Phosphorylation PhosphoSitePlus
S64 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17081983, 20068231
R66 Methylation PhosphoSitePlus
K68 Methylation PhosphoSitePlus
S77 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983
T82 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S108 Phosphorylation phospho.ELM 17081983
S109 Phosphorylation phospho.ELM 17081983
S110 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
T134 Phosphorylation PhosphoSitePlus
S137 Phosphorylation PhosphoSitePlus
S151 Phosphorylation PhosphoSitePlus
Y158 Phosphorylation PhosphoSitePlus
Y160 Phosphorylation PhosphoSitePlus
K194 Sumoylation PhosphoSitePlus
S198 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18669648, 20068231
S204 Phosphorylation PhosphoSitePlus
S207 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 15144186, ...18669648, 20068231
S209 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 15144186, ...18669648, 20068231
S211 Phosphorylation PhosphoSitePlus   UniProt 23186163
S216 Phosphorylation PhosphoSitePlus
S218 Phosphorylation PhosphoSitePlus
S223 Phosphorylation PhosphoSitePlus
T237 Phosphorylation PhosphoSitePlus   UniProt 21406692
S238 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S241 Phosphorylation PhosphoSitePlus
S242 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 16964243, ...18669648, 24275569, 19690332, 20068231
T263 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 16964243, ...15302935, 15144186, 18669648, 19690332, 20068231, 17081983
S265 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 16964243, ...15302935, 15144186, 18669648, 20068231, 17081983
S316 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
T317 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S318 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S325 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692
S328 Phosphorylation PhosphoSitePlus   UniProt 21406692
S329 Phosphorylation PhosphoSitePlus
S333 Phosphorylation PhosphoSitePlus
S334 Phosphorylation PhosphoSitePlus
S335 Phosphorylation PhosphoSitePlus
S336 Phosphorylation PhosphoSitePlus
S338 Phosphorylation PhosphoSitePlus
S341 Phosphorylation PhosphoSitePlus
S346 Phosphorylation PhosphoSitePlus
S348 Phosphorylation PhosphoSitePlus
T354 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983
S356 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 15302935
S358 Phosphorylation PhosphoSitePlus
Y359 Phosphorylation phospho.ELM 18669648
T364 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S370 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18669648, 24275569, 20068231
S372 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18669648, 24275569, 20068231
Y374 Phosphorylation PhosphoSitePlus
S376 Phosphorylation PhosphoSitePlus
S378 Phosphorylation PhosphoSitePlus
S380 Phosphorylation PhosphoSitePlus
S381 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692, ...20068231
S387 Phosphorylation PhosphoSitePlus
S393 Phosphorylation PhosphoSitePlus
T406 Phosphorylation PhosphoSitePlus
S407 Phosphorylation PhosphoSitePlus
S430 Phosphorylation PhosphoSitePlus
Y436 Phosphorylation PhosphoSitePlus
S473 Phosphorylation PhosphoSitePlus
S479 Phosphorylation PhosphoSitePlus
S492 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S538 Phosphorylation PhosphoSitePlus
S539 Phosphorylation PhosphoSitePlus
T541 Phosphorylation PhosphoSitePlus
S563 Phosphorylation PhosphoSitePlus
S578 Phosphorylation PhosphoSitePlus
S581 Phosphorylation PhosphoSitePlus
Y592 Phosphorylation PhosphoSitePlus
S595 Phosphorylation PhosphoSitePlus
S600 Phosphorylation PhosphoSitePlus
Y608 Phosphorylation PhosphoSitePlus
S620 Phosphorylation PhosphoSitePlus
S621 Phosphorylation PhosphoSitePlus
S642 Phosphorylation PhosphoSitePlus
S643 Phosphorylation PhosphoSitePlus   UniProt 23186163
S831 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S833 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S837 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S845 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692, 20068231
S848 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692, 20068231
Y851 Phosphorylation phospho.ELM 18669648
S853 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692, 20068231
S865 Phosphorylation PhosphoSitePlus
S873 O-Glycosylation GlyGen 23301498, 30444036, 30379171, ...33214551, 34019948, 32119511
S873 Phosphorylation PhosphoSitePlus   UniProt 23186163
S875 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15302935, 18669648, 23186163, ...17081983
S877 O-Glycosylation GlyGen 23301498, 30444036, 30379171, ...33214551, 34019948, 32119511
S877 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18220336, 15302935, 18669648, 24275569, 20068231
S879 Phosphorylation PhosphoSitePlus
T882 Phosphorylation PhosphoSitePlus   UniProt 21406692
S943 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983
S949 Phosphorylation PhosphoSitePlus
T984 Phosphorylation PhosphoSitePlus
T985 Phosphorylation PhosphoSitePlus
S986 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692, ...19690332
S993 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...15302935, 18669648, 19690332, 20068231, 16964243
S1010 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 15302935, 18669648, ...24275569, 20068231
S1014 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 20068231, 18669648, 19690332, ...24275569
S1017 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 15302935, 18669648, ...24275569, 19690332, 20068231
T1033 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983
S1056 Phosphorylation PhosphoSitePlus
S1065 Phosphorylation PhosphoSitePlus
S1068 Phosphorylation PhosphoSitePlus
T1170 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
S1190 Phosphorylation PhosphoSitePlus
S1191 Phosphorylation PhosphoSitePlus   UniProt 21406692
S1194 Phosphorylation PhosphoSitePlus   UniProt 21406692
S1197 Phosphorylation PhosphoSitePlus
S1208 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17081983, 20068231, ...18220336
S1210 Phosphorylation PhosphoSitePlus   UniProt 21406692, 24275569
S1213 Phosphorylation PhosphoSitePlus
S1217 Phosphorylation PhosphoSitePlus
S1230 Phosphorylation PhosphoSitePlus   UniProt 20068231
S1232 Phosphorylation PhosphoSitePlus
S1240 Phosphorylation PhosphoSitePlus
T1244 Phosphorylation PhosphoSitePlus
S1274 Phosphorylation PhosphoSitePlus
S1279 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S1282 Phosphorylation PhosphoSitePlus
S1288 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S1290 Phosphorylation PhosphoSitePlus
S1292 Phosphorylation PhosphoSitePlus
S1295 Phosphorylation PhosphoSitePlus
T1318 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S1364 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
S1366 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
S1382 Phosphorylation PhosphoSitePlus   UniProt 17525332
S1386 Phosphorylation PhosphoSitePlus   UniProt 23186163
T1405 Phosphorylation PhosphoSitePlus
S1406 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1409 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1423 Phosphorylation PhosphoSitePlus
S1433 Phosphorylation PhosphoSitePlus
T1436 Phosphorylation PhosphoSitePlus
S1438 Phosphorylation PhosphoSitePlus   UniProt 20068231
S1445 Phosphorylation PhosphoSitePlus
S1452 Phosphorylation PhosphoSitePlus
L1453 Phosphorylation UniProt 18669648
S1455 Phosphorylation PhosphoSitePlus
G1456 Phosphorylation UniProt 18669648
Y1461 Phosphorylation PhosphoSitePlus
S1465 Phosphorylation PhosphoSitePlus   UniProt 21406692
D1466 Phosphorylation UniProt 18669648
T1522 Phosphorylation PhosphoSitePlus
K1557 Ubiquitination PhosphoSitePlus
K1593 Ubiquitination PhosphoSitePlus
S1601 Phosphorylation PhosphoSitePlus
K1616 Ubiquitination PhosphoSitePlus
S1657 Phosphorylation PhosphoSitePlus
S1659 Phosphorylation PhosphoSitePlus
S1660 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S64 Phosphorylation HPRD 17081983, 20068231, 19664995
S77 Phosphorylation HPRD 18767875, 17081983, 20068231
T105 Phosphorylation HPRD 17081983
S108 Phosphorylation HPRD 17081983
S109 Phosphorylation HPRD 19651622, 17081983
S110 Phosphorylation HPRD 19651622, 17081983, 20068231
T134 Phosphorylation HPRD 18452278
S137 Phosphorylation HPRD 18452278
S198 Phosphorylation HPRD 17322306, 18767875, 19664995, ...18452278, 19651622, 18669648, 18707149, 20166139, 20068231
S204 Phosphorylation HPRD 20068231
S207 Phosphorylation HPRD 19413330, 18767875, 19664994, ...19664995, 15144186, 19651622, 18669648, 20068231
S209 Phosphorylation HPRD 19413330, 18767875, 19664994, ...15144186, 19651622, 18669648, 20068231
S211 Phosphorylation HPRD 18767875, 19664995, 20068231
T237 Phosphorylation HPRD 17081983
S238 Phosphorylation HPRD 19413330, 17287340, 17081983, ...18452278, 18669648, 20068231
S241 Phosphorylation HPRD 18767875, 17287340, 19664995, ...20068231, 20058876
S242 Phosphorylation HPRD 19413330, 20058876, 18767875, ...19664994, 19664995, 18452278, 15302935, 18669648, 20068231
T263 Phosphorylation HPRD 19413330, 20230923, 20058876, ...15302935, 19664995, 15144186, 18452278, 19651622, 18669648, 20068231
S265 Phosphorylation HPRD 19413330, 16964243, 20230923, ...20058876, 15302935, 19664995, 15144186, 18452278, 19651622, 18669648, 20068231
S316 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231
T317 Phosphorylation HPRD 19413330, 19651622, 18669648, ...17081983, 20068231
S318 Phosphorylation HPRD 19413330, 19651622, 18669648
S325 Phosphorylation HPRD 19413330, 19651622, 18669648, ...17081983, 20068231
S328 Phosphorylation HPRD 19651622, 20068231
T354 Phosphorylation HPRD 18669648, 16964243
S356 Phosphorylation HPRD 18669648, 16964243, 17081983
S358 Phosphorylation HPRD 17081983
Y359 Phosphorylation HPRD 18669648
T364 Phosphorylation HPRD 18669648, 19664995
S370 Phosphorylation HPRD 19413330, 19651622, 18669648, ...20068231
S372 Phosphorylation HPRD 19413330, 17081983, 18767875, ...19651622, 18669648, 20068231
Y374 Phosphorylation HPRD 20068231
S380 Phosphorylation HPRD 19651622, 18767875, 17081983, ...20068231, 18452278
S381 Phosphorylation HPRD 19413330, 17081983, 18452278, ...19651622, 18669648, 20068231
S492 Phosphorylation HPRD 17081983
S581 Phosphorylation HPRD 17525332
S621 Phosphorylation HPRD 20068231
S643 Phosphorylation HPRD 17081983, 20068231
S831 Phosphorylation HPRD 19651622, 18669648, 20068231
S833 Phosphorylation HPRD 19651622, 18669648, 20068231
S837 Phosphorylation HPRD 19651622, 18669648, 20068231
S845 Phosphorylation HPRD 18669648, 20068231, 18452278
S848 Phosphorylation HPRD 18669648, 20068231, 18452278
Y851 Phosphorylation HPRD 18669648
S853 Phosphorylation HPRD 19651622, 18669648, 20068231, ...18452278
S875 Phosphorylation HPRD 19413330, 17081983, 18452278, ...19651622, 18669648, 20068231
S877 Phosphorylation HPRD 19413330, 17322306, 18767875, ...19664995, 18452278, 19651622, 18669648, 18707149, 20166139, 20068231
S943 Phosphorylation HPRD 18452278
T948 Phosphorylation HPRD 17081983
S949 Phosphorylation HPRD 17081983
T984 Phosphorylation HPRD 19413330
T985 Phosphorylation HPRD 20068231
S986 Phosphorylation HPRD 19413330, 19664995, 18452278, ...19651622, 18669648, 20068231
S993 Phosphorylation HPRD 19413330, 18691976, 16964243, ...20058876, 19664994, 19664995, 18452278, 19651622, 18669648, 20068231, 17081983
S1010 Phosphorylation HPRD 19651622, 18669648, 20068231, ...18452278
S1014 Phosphorylation HPRD 19413330, 18669648, 20068231, ...18452278
S1017 Phosphorylation HPRD 19413330, 18767875, 18452278, ...19651622, 18669648, 20068231
T1033 Phosphorylation HPRD 18452278
T1037 Phosphorylation HPRD 17081983
T1038 Phosphorylation HPRD 17081983
S1056 Phosphorylation HPRD 17525332
S1065 Phosphorylation HPRD 20068231, 18452278
S1068 Phosphorylation HPRD 20068231, 18452278
T1170 Phosphorylation HPRD 20068231
S1191 Phosphorylation HPRD 20068231
S1194 Phosphorylation HPRD 20068231
S1208 Phosphorylation HPRD 19651622, 19664995, 20068231
S1210 Phosphorylation HPRD 19651622, 17081983, 20068231
S1213 Phosphorylation HPRD 17081983
S1230 Phosphorylation HPRD 17322306, 20068231
S1232 Phosphorylation HPRD 17322306
S1279 Phosphorylation HPRD 17081983, 20068231
S1288 Phosphorylation HPRD 17081983
T1318 Phosphorylation HPRD 17081983
S1364 Phosphorylation HPRD 20068231
S1366 Phosphorylation HPRD 19664995, 20068231
S1382 Phosphorylation HPRD 17525332
T1405 Phosphorylation HPRD 17081983
S1409 Phosphorylation HPRD 17081983
S1433 Phosphorylation PhosphoSitePlus
S1438 Phosphorylation HPRD   PhosphoSitePlus 20068231
S1446 Phosphorylation PhosphoSitePlus
S1453 Phosphorylation HPRD   PhosphoSitePlus 18669648, 18452278
S1456 Phosphorylation HPRD   PhosphoSitePlus 19651622, 18669648, 20068231, ...18452278
S1466 Phosphorylation HPRD   PhosphoSitePlus 19651622, 18669648, 20068231, ...18452278


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R66 C66 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R66 G66 Biomuta DOID:3571 / liver cancer [ cosmic ]
S108 P108 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S108 L108 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S110 L110 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S110 * Biomuta DOID:3571 / liver cancer [ cosmic ]
T134 I134 Biomuta DOID:4159 / skin cancer [ cosmic ]
S204 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S207 F207 Biomuta DOID:4159 / skin cancer [ cosmic ]
S209 P209 Biomuta DOID:363 / uterine cancer [ cosmic ]
S218 Y218 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S218 C218 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
T237 A237 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S325 F325 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S328 F328 Biomuta DOID:4159 / skin cancer [ cosmic ]
S333 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S338 L338 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S346 F346 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S358 F358 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S370 F370 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S380 L380 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
S387 G387 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T541 M541 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ icgc ]
Y592 D592 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S600 R600 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S621 F621 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S837 C837 Biomuta DOID:263 / kidney cancer [ cosmic ]
S875 F875 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S879 L879 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T882 A882 Biomuta DOID:1319 / brain cancer [ cosmic ]
T985 I985 Biomuta [ cosmic, cosmic ] DOID:1612 / breast cancer [ cosmic, icgc, cosmic, icgc, cosmic ] DOID:3571 / liver cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic, cosmic, cosmic ] DOID:9256 / colorectal cancer [ cosmic, cosmic, cosmic ] DOID:363 / uterine cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic, icgc, cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S1010 F1010 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1014 Y1014 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S1014 F1014 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1065 I1065 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1190 G1190 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1190 N1190 Biomuta DOID:363 / uterine cancer [ cosmic ]
S1213 L1213 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S1217 G1217 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1232 L1232 Biomuta DOID:1612 / breast cancer [ cosmic ]
S1240 T1240 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1240 I1240 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T1244 I1244 Biomuta DOID:3571 / liver cancer [ cosmic ]
S1279 F1279 Biomuta [ cosmic ]
S1279 Y1279 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T1318 A1318 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T1318 M1318 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1386 F1386 Biomuta [ cosmic ]
S1433 F1433 Biomuta [ cosmic ] DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
S1455 F1455 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1456 F1456 Biomuta DOID:4606 / bile duct cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, cosmic, icgc, cosmic ] DOID:4159 / skin cancer [ cosmic, cosmic, cosmic, cosmic, icgc, cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ] DOID:363 / uterine cancer [ cosmic, cosmic, icgc, cosmic, icgc ] DOID:263 / kidney cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic, icgc ]
G1456 D1456 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic ]
Y1461 C1461 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K1593 E1593 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S1601 F1601 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1660 N1660 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]