iPTMnet Report for Q5T1H1 (EYS)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q5T1H1 / EYS_HUMAN
Protein Name Protein eyes shut homolog precursor
Gene Name Name: EYS
Synonyms:C6orf178,C6orf179,C6orf180,EGFL10,EGFL11,SPAM;ORFNames:UNQ9424/PRO34591;
Organism Homo sapiens (Human)

PRO ID PR:Q5T1H1
DAG View
PRO Name protein eyes shut homolog (human)
Definition A protein eyes shut that is encoded in the genome of human.
Short Label hEYS
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q5T1H1 (EYS) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S16 Phosphorylation PhosphoSitePlus
T23 Phosphorylation PhosphoSitePlus
K139 Sumoylation PhosphoSitePlus
T1247 Phosphorylation PhosphoSitePlus
S1338 Phosphorylation PhosphoSitePlus
T1558 Phosphorylation PhosphoSitePlus
T1673 Phosphorylation PhosphoSitePlus
S1675 Phosphorylation PhosphoSitePlus
S1676 Phosphorylation PhosphoSitePlus
S1681 Phosphorylation PhosphoSitePlus
S1685 Phosphorylation PhosphoSitePlus
Y1819 Phosphorylation PhosphoSitePlus
Y1823 Phosphorylation PhosphoSitePlus
Y1971 Phosphorylation PhosphoSitePlus
T2667 Phosphorylation PhosphoSitePlus
S2670 Phosphorylation PhosphoSitePlus
Y2675 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S16 I16 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T1558 K1558 Biomuta DOID:1324 / lung cancer [ cosmic ]
T1558 S1558 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
T1673 I1673 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S1675 F1675 Biomuta DOID:3571 / liver cancer [ cosmic ]
S1685 A1685 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S1685 L1685 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
Y1823 N1823 Biomuta DOID:263 / kidney cancer [ cosmic ]
S2670 * Biomuta DOID:363 / uterine cancer [ cosmic ]